[3H]EMPA [Ligand Id: 9467] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2385133
  • OX1 receptor/Orexin receptor 1 in Human [ChEMBL: CHEMBL5113] [GtoPdb: 321] [UniProtKB: O43613]
  • This target only has 1 pki data point
1 CHEMBL2385133_lig_chart_1 Orexin receptor 1 Human
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  • OX2 receptor/Orexin receptor 2 in Human [ChEMBL: CHEMBL4792] [GtoPdb: 322] [UniProtKB: O43614]
  • This target only has 1 pki data point
2 CHEMBL2385133_lig_chart_2 Orexin receptor 2 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
OX1 receptor/Orexin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5113] [GtoPdb: 321] [UniProtKB: O43613]
ChEMBL Binding affinity to orexin receptor 1 (unknown origin) B 6.05 pKi 900 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 4761-4769 [PMID:23891187]
OX2 receptor/Orexin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4792] [GtoPdb: 322] [UniProtKB: O43614]
GtoPdb - - 9 pKd 1 nM Kd Br. J. Pharmacol. (2009) 156: 1326-41 [PMID:19751316];
Mol. Pharmacol. (2010) 78: 81-93 [PMID:20404073]
ChEMBL Binding affinity to orexin receptor 2 (unknown origin) B 8.96 pKi 1.1 nM Ki Bioorg. Med. Chem. Lett. (2013) 23: 4761-4769 [PMID:23891187]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]