GSK2210875 [Ligand Id: 6435] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1630057 (GSK2210875) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
| ChEMBL | Antagonist activity at mGluR5 | F | 4.5 | pIC50 | 31622.78 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7521-7524 [PMID:21051228] |
| GtoPdb | - | - | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7521-4 [PMID:21051228] |
| ChEMBL | Antagonist activity at human mGluR5 expressed in CHO cells assessed as doxycycline induced calcium mobilization | F | 7.4 | pIC50 | 39.81 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7521-7524 [PMID:21051228] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641352] [GtoPdb: 293] [UniProtKB: Q3UVX5] | ||||||||
| ChEMBL | Antagonist activity at mGluR5 in mouse astrocytes assessed as inhibition of L-quisqualate induced calcium release by FLIPR assay | F | 7.5 | pIC50 | 31.62 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 7521-7524 [PMID:21051228] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
