purvalanol B [Ligand Id: 7806] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL23254 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cdc2 in Patiria pectinifera (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5124] [UniProtKB: Q17066] | ||||||||
| ChEMBL | Inhibition of starfish cdc2/cyclin B assessed as [32P] incorporation in histone H1 from 1.5 mM [gamma32P]ATP | B | 6.6 | pIC50 | 250 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| ChEMBL | Inhibition of starfish cdc2/cyclin B assessed as [32P] incorporation in histone H1 from 150 M [gamma32P]ATP | B | 7.3 | pIC50 | 50 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546] | ||||||||
| ChEMBL | Inhibition of Saccharomyces cerevisiae cdc28 | B | 5.92 | pIC50 | 1200 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| ChEMBL | Binding affinity to cyclin-dependent kinase 1 (CDK1) | B | 4.7 | pIC50 | 20000 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] | ||||||||
| ChEMBL | Inhibition of cyclin dependent kinase 1-cyclinB | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| ChEMBL | In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2000) 43: 1282-1292 [PMID:10753466] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] | ||||||||
| ChEMBL | Inhibition of human cdc2/cyclin B assessed as [32P] incorporation in histone H1 from [gamma32P]ATP | B | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Inhibition of human cdk2/cyclin E | B | 8.05 | pIC50 | 9 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| GtoPdb | CDK2/cyclin A complex used in assay | - | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-8 [PMID:9677190] |
| ChEMBL | Inhibition of human cdk2/cyclin A | B | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
| GtoPdb | CDK2/cyclin A complex used in assay | - | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-8 [PMID:9677190] |
| ChEMBL | Inhibition of Cyclin A-cyclin-dependent kinase 2 | B | 8.22 | pIC50 | 6 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020, P24864, P24941] | ||||||||
| ChEMBL | Inhibition of Cyclin E-cyclin-dependent kinase 2 | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| GtoPdb | CDK2/cyclin A complex used in assay | - | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-8 [PMID:9677190] |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802, P24385] | ||||||||
| GtoPdb | CDK4/cyclin D1 complex used in assay | - | 5 | pIC50 | >10000 | nM | IC50 | Science (1998) 281: 533-8 [PMID:9677190] |
| ChEMBL | Inhibition of Cyclin D1-cyclin-dependent kinase 4 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| ChEMBL | Inhibition of human cdk4/cyclin D1 | B | 5 | pIC50 | >10000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
| GtoPdb | CDK5/p35 complex used in assay | - | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-8 [PMID:9677190] |
| ChEMBL | Inhibition of human cdk5/p35 | B | 8.22 | pIC50 | 6 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Inhibition of human GSK3-beta | B | 5 | pIC50 | >10000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
| ChEMBL | Inhibition of human insulin receptor | B | 5.66 | pIC50 | 2200 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
| ChEMBL | Inhibition of human Erk1 | B | 5.48 | pIC50 | 3333 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| ChEMBL | Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1) | B | 5.48 | pIC50 | 3300 | nM | IC50 | J Med Chem (2002) 45: 2366-2378 [PMID:12036347] |
| neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
| ChEMBL | Inhibition of TrkA (unknown origin) by cell-based assay | B | 5.77 | pIC50 | 1710 | nM | IC50 | Medchemcomm (2012) 3: 322-325 |
| ChEMBL | Inhibition of TrkA (unknown origin) | B | 7.29 | pIC50 | 51 | nM | IC50 | Medchemcomm (2012) 3: 322-325 |
| neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
| ChEMBL | Inhibition of TrkB (unknown origin) by cell-based assay | B | 5.89 | pIC50 | 1300 | nM | IC50 | Medchemcomm (2012) 3: 322-325 |
| ChEMBL | Inhibition of TrkB (unknown origin) | B | 7.96 | pIC50 | 11 | nM | IC50 | Medchemcomm (2012) 3: 322-325 |
| protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
| ChEMBL | Inhibition of human PKCalpha | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
| ChEMBL | Inhibition of human PKCbeta1 | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| ChEMBL | Inhibition of human PKCbeta2 | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
| ChEMBL | Inhibition of human PKCdelta | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
| ChEMBL | Inhibition of human PKCepsilon | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723] | ||||||||
| ChEMBL | Inhibition of human PKCeta | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129] | ||||||||
| ChEMBL | Inhibition of human PKCgamma | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
| protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513] | ||||||||
| ChEMBL | Inhibition of human PKCzeta | B | 4 | pIC50 | >100000 | nM | IC50 | Science (1998) 281: 533-538 [PMID:9677190] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
