purvalanol B [Ligand Id: 7806] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL23254
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  • Cell division control protein 28 in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
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  • cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
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  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
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  • cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • mitogen-activated protein kinase 3/MAP kinase ERK1 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
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  • neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
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  • neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
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  • protein kinase C alpha/Protein kinase C alpha in Human [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
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  • protein kinase C beta/Protein kinase C beta in Human [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
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  • protein kinase C delta/Protein kinase C delta in Human [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
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  • protein kinase C epsilon/Protein kinase C epsilon in Human [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
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  • protein kinase C eta/Protein kinase C eta in Human [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
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  • protein kinase C gamma/Protein kinase C gamma in Human [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
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  • protein kinase C zeta/Protein kinase C zeta in Human [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cdc2 in Patiria pectinifera (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5124] [UniProtKB: Q17066]
ChEMBL Inhibition of starfish cdc2/cyclin B assessed as [32P] incorporation in histone H1 from 1.5 mM [gamma32P]ATP B 6.6 pIC50 250 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
ChEMBL Inhibition of starfish cdc2/cyclin B assessed as [32P] incorporation in histone H1 from 150 M [gamma32P]ATP B 7.3 pIC50 50 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
Cell division control protein 28 in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5213] [UniProtKB: P00546]
ChEMBL Inhibition of Saccharomyces cerevisiae cdc28 B 5.92 pIC50 1200 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493]
ChEMBL Binding affinity to cyclin-dependent kinase 1 (CDK1) B 4.7 pIC50 20000 nM IC50 J. Med. Chem. (2002) 45: 2366-2378 [PMID:12036347]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067P06493P14635Q8WWL7]
ChEMBL Inhibition of cyclin dependent kinase 1-cyclinB B 8.22 pIC50 6 nM IC50 J. Med. Chem. (2002) 45: 2366-2378 [PMID:12036347]
ChEMBL In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes B 8.22 pIC50 6 nM IC50 J. Med. Chem. (2000) 43: 1282-1292 [PMID:10753466]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493P14635]
ChEMBL Inhibition of human cdc2/cyclin B assessed as [32P] incorporation in histone H1 from [gamma32P]ATP B 8.22 pIC50 6 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Inhibition of human cdk2/cyclin E B 8.05 pIC50 9 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
GtoPdb CDK2/cyclin A complex used in assay - 8.22 pIC50 6 nM IC50 Science (1998) 281: 533-8 [PMID:9677190]
ChEMBL Inhibition of human cdk2/cyclin A B 8.22 pIC50 6 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248P24941P78396]
GtoPdb CDK2/cyclin A complex used in assay - 8.22 pIC50 6 nM IC50 Science (1998) 281: 533-8 [PMID:9677190]
ChEMBL Inhibition of Cyclin A-cyclin-dependent kinase 2 B 8.22 pIC50 6 nM IC50 J. Med. Chem. (2002) 45: 2366-2378 [PMID:12036347]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020P24864P24941]
ChEMBL Inhibition of Cyclin E-cyclin-dependent kinase 2 B 8.05 pIC50 9 nM IC50 J. Med. Chem. (2002) 45: 2366-2378 [PMID:12036347]
GtoPdb CDK2/cyclin A complex used in assay - 8.22 pIC50 6 nM IC50 Science (1998) 281: 533-8 [PMID:9677190]
cyclin dependent kinase 4/Cyclin-dependent kinase 4/cyclin D1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907601] [GtoPdb: 1976] [UniProtKB: P11802P24385]
GtoPdb CDK4/cyclin D1 complex used in assay - 5 pIC50 >10000 nM IC50 Science (1998) 281: 533-8 [PMID:9677190]
ChEMBL Inhibition of Cyclin D1-cyclin-dependent kinase 4 B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2002) 45: 2366-2378 [PMID:12036347]
ChEMBL Inhibition of human cdk4/cyclin D1 B 5 pIC50 >10000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
GtoPdb CDK5/p35 complex used in assay - 8.22 pIC50 6 nM IC50 Science (1998) 281: 533-8 [PMID:9677190]
ChEMBL Inhibition of human cdk5/p35 B 8.22 pIC50 6 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of human GSK3-beta B 5 pIC50 >10000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
ChEMBL Inhibition of human insulin receptor B 5.66 pIC50 2200 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
ChEMBL Inhibition of human Erk1 B 5.48 pIC50 3333 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
ChEMBL Inhibition of Mitogen-activated protein kinase 3 (MAPK-ERK1) B 5.48 pIC50 3300 nM IC50 J. Med. Chem. (2002) 45: 2366-2378 [PMID:12036347]
neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629]
ChEMBL Inhibition of TrkA (unknown origin) by cell-based assay B 5.77 pIC50 1710 nM IC50 MedChemComm (2012) 3: 322-325
ChEMBL Inhibition of TrkA (unknown origin) B 7.29 pIC50 51 nM IC50 MedChemComm (2012) 3: 322-325
neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620]
ChEMBL Inhibition of TrkB (unknown origin) by cell-based assay B 5.89 pIC50 1300 nM IC50 MedChemComm (2012) 3: 322-325
ChEMBL Inhibition of TrkB (unknown origin) B 7.96 pIC50 11 nM IC50 MedChemComm (2012) 3: 322-325
protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252]
ChEMBL Inhibition of human PKCalpha B 4 pIC50 >100000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771]
ChEMBL Inhibition of human PKCbeta1 B 4 pIC50 >100000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
ChEMBL Inhibition of human PKCbeta2 B 4 pIC50 >100000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655]
ChEMBL Inhibition of human PKCdelta B 4 pIC50 >100000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156]
ChEMBL Inhibition of human PKCepsilon B 4 pIC50 >100000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723]
ChEMBL Inhibition of human PKCeta B 4 pIC50 >100000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
protein kinase C gamma/Protein kinase C gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2938] [GtoPdb: 1484] [UniProtKB: P05129]
ChEMBL Inhibition of human PKCgamma B 4 pIC50 >100000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]
protein kinase C zeta/Protein kinase C zeta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3438] [GtoPdb: 1491] [UniProtKB: Q05513]
ChEMBL Inhibition of human PKCzeta B 4 pIC50 >100000 nM IC50 Science (1998) 281: 533-538 [PMID:9677190]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]