Dickkopf 1   Click here for help

GtoPdb Ligand ID: 3701

Synonyms: Dickkopf-related protein 1 | DKK 1
Comment: DKK1 is a secreted protein that inhibits canonical Wnt/β-catenin signalling via interaction with the LRP5/LRP6 co-receptor. It is involved in normal biological processes such as embryonic development and bone homeostasis [5]. In the cancer setting DKK1 promotes an immunosuppressive tumour microenvironment [3,6], and is associated with cancer cell proliferation, invasion, and tumour growth [1,4]. Neutralising DKK1 function is being investigated as an oncology therapeutic strategy.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Synonyms Click here for help
Dickkopf-related protein 1 | DKK 1
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
DKK1 dickkopf WNT signaling pathway inhibitor 1 Human Dickkopf 1 dickkopf 1 homolog (Xenopus laevis), dickkopf (Xenopus laevis) homolog 1, DKK-1, SK
Database Links Click here for help
Ensembl Gene ENSG00000104901 (Hs)
GtoPdb PubChem SID 178100590
Human Protein Atlas ENSG00000104901 (Hs)
PubChem SID 56311385 (Hs)
UniProtKB O94907 (Hs)
Wikipedia DKK1