ChEMBL ligand: CHEMBL1551597
Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975] There should be some charts here, you may need to enable JavaScript!
Cav3.2/Voltage-gated T-type calcium channel alpha-1H subunit in Human [ChEMBL: CHEMBL1859] [GtoPdb: 536] [UniProtKB: O95180] There should be some charts here, you may need to enable JavaScript!
CatSper1 in Human [GtoPdb: 388] [UniProtKB: Q8NEC5] CatSper1 in Mouse [GtoPdb: 388] [UniProtKB: Q91ZR5] There should be some charts here, you may need to enable JavaScript!
CatSper2 in Human [GtoPdb: 389] [UniProtKB: Q96P56] CatSper2 in Mouse [GtoPdb: 389] [UniProtKB: A2ARP9] There should be some charts here, you may need to enable JavaScript!
CatSper3 in Human [GtoPdb: 390] [UniProtKB: Q86XQ3] CatSper3 in Mouse [GtoPdb: 390] [UniProtKB: Q80W99] There should be some charts here, you may need to enable JavaScript!
CatSper4 in Human [GtoPdb: 391] [UniProtKB: Q7RTX7] CatSper4 in Mouse [GtoPdb: 391] [UniProtKB: Q8BVN3] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975]
ChEMBL	Inhibition of human N type calcium channel Cav2.2 endogenously expressed in SH-SY5Y cells assessed as calcium influx by FRIPR assay	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem (2020) 28: 115655-115655 [PMID:32828422]
Cav3.2/Voltage-gated T-type calcium channel alpha-1H subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1859] [GtoPdb: 536] [UniProtKB: O95180]
ChEMBL	Inhibition of human T type calcium channel Cav3.2 expressed in HEK-293T cells assessed as calcium influx by FRIPR assay	B	5.7	pIC50	2000	nM	IC50	Bioorg Med Chem (2020) 28: 115655-115655 [PMID:32828422]
CatSper1 in Human [GtoPdb: 388] [UniProtKB: Q8NEC5]
GtoPdb	Patch clamp electrophysiology, kinetic rapid mixing fluometry	-	5.7	pIC50	2000	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]; Nature (2011) 471: 382-6 [PMID:21412338]
CatSper1 in Mouse [GtoPdb: 388] [UniProtKB: Q91ZR5]
GtoPdb	Patch clamp electrophysiology	-	5.6	pIC50	>2500	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]
CatSper2 in Human [GtoPdb: 389] [UniProtKB: Q96P56]
GtoPdb	Patch clamp electrophysiology and kinetic rapid mixing fluometry.	-	5.7	pIC50	2000	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]; Nature (2011) 471: 382-6 [PMID:21412338]
CatSper2 in Mouse [GtoPdb: 389] [UniProtKB: A2ARP9]
GtoPdb	Patch clamp electrophysiology.	-	4.6	pIC50	>25000	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]
CatSper3 in Human [GtoPdb: 390] [UniProtKB: Q86XQ3]
GtoPdb	Patch clamp electrophysiology, kinetic rapid mixing fluometry.	-	5.7	pIC50	2000	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]; Nature (2011) 471: 382-6 [PMID:21412338]
CatSper3 in Mouse [GtoPdb: 390] [UniProtKB: Q80W99]
GtoPdb	Patch clamp electrophysiology.	-	5.6	pIC50	>2500	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]
CatSper4 in Human [GtoPdb: 391] [UniProtKB: Q7RTX7]
GtoPdb	Patch clamp electrophysiology, kinetic rapid mixing fluometry.	-	5.7	pIC50	2000	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]; Nature (2011) 471: 382-6 [PMID:21412338]
CatSper4 in Mouse [GtoPdb: 391] [UniProtKB: Q8BVN3]
GtoPdb	Patch clamp electrophysiology.	-	5.6	pIC50	>2500	nM	IC50	Nature (2011) 471: 387-91 [PMID:21412339]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]