orexin-B [Ligand Id: 1699] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL413434 (Orexin-B) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OX1 receptor/Orexin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5113] [GtoPdb: 321] [UniProtKB: O43613] | ||||||||
| ChEMBL | Agonist activity against human orexin 1 receptor; EC50; nM | F | 9.08 | pEC50 | 0.83 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 111-113 [PMID:12467628] |
| ChEMBL | Agonist activity against human orexin 1 receptor; EC50; nM | F | 9.08 | pEC50 | 0.83 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 111-113 [PMID:12467628] |
| GtoPdb | - | - | 9.2 | pEC50 | - | - | - |
J Pharmacol Exp Ther (2003) 305: 507-14 [PMID:12606634]; FEBS Lett (2002) 526: 11-4 [PMID:12208495]; Cell Mol Life Sci (2008) 65: 1948-56 [PMID:18488139]; Br J Pharmacol (2004) 141: 340-6 [PMID:14691055]; Biochem Biophys Res Commun (2001) 280: 976-81 [PMID:11162621]; Neurosci Lett (2011) 494: 57-60 [PMID:21362456]; Cell (1998) 92: 573-85 [PMID:9491897]; Br J Pharmacol (1999) 128: 1-3 [PMID:10498827]; Br J Pharmacol (2010) 159: 212-21 [PMID:20002100] |
| OX2 receptor/Orexin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4792] [GtoPdb: 322] [UniProtKB: O43614] | ||||||||
| GtoPdb | - | - | 10 | pEC50 | - | - | - |
J Pharmacol Exp Ther (2003) 305: 507-14 [PMID:12606634]; J Neurophysiol (2003) 90: 693-702 [PMID:12702704]; FEBS Lett (2002) 526: 11-4 [PMID:12208495]; Biochem Biophys Res Commun (2001) 280: 976-81 [PMID:11162621]; Cell (1998) 92: 573-85 [PMID:9491897]; Br J Pharmacol (1999) 128: 1-3 [PMID:10498827]; Cell Signal (2008) 20: 1651-61 [PMID:18599270] |
| ChEMBL | Agonist activity against human orexin 2 receptor; EC50; nM | F | 10.09 | pEC50 | 0.08 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 111-113 [PMID:12467628] |
| ChEMBL | Agonist activity against human orexin 2 receptor; EC50; nM | F | 10.09 | pEC50 | 0.08 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 111-113 [PMID:12467628] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
