orexin-B [Ligand Id: 1699] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL413434 (Orexin-B) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| OX1 receptor/Orexin receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5113] [GtoPdb: 321] [UniProtKB: O43613] | ||||||||
| ChEMBL | Agonist activity at OX1R (unknown origin) | F | 5.6 | pEC50 | 2500 | nM | EC50 | Bioorg Med Chem Lett (2022) 60: 128555-128555 [PMID:35051577] |
| ChEMBL | Agonist activity against human orexin 1 receptor; EC50; nM | F | 9.08 | pEC50 | 0.83 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 111-113 [PMID:12467628] |
| ChEMBL | Agonist activity against human orexin 1 receptor; EC50; nM | F | 9.08 | pEC50 | 0.83 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 111-113 [PMID:12467628] |
| GtoPdb | - | - | 9.2 | pEC50 | - | - | - |
J Pharmacol Exp Ther (2003) 305: 507-14 [PMID:12606634]; FEBS Lett (2002) 526: 11-4 [PMID:12208495]; Cell Mol Life Sci (2008) 65: 1948-56 [PMID:18488139]; Br J Pharmacol (2004) 141: 340-6 [PMID:14691055]; Biochem Biophys Res Commun (2001) 280: 976-81 [PMID:11162621]; Neurosci Lett (2011) 494: 57-60 [PMID:21362456]; Cell (1998) 92: 573-85 [PMID:9491897]; Br J Pharmacol (1999) 128: 1-3 [PMID:10498827]; Br J Pharmacol (2010) 159: 212-21 [PMID:20002100] |
| OX2 receptor/Orexin receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4792] [GtoPdb: 322] [UniProtKB: O43614] | ||||||||
| ChEMBL | Agonist activity at OX2R (unknown origin) | F | 7.22 | pEC50 | 60 | nM | EC50 | Bioorg Med Chem Lett (2022) 60: 128555-128555 [PMID:35051577] |
| GtoPdb | - | - | 10 | pEC50 | - | - | - |
Cell (1998) 92: 573-85 [PMID:9491897]; Br J Pharmacol (1999) 128: 1-3 [PMID:10498827]; J Pharmacol Exp Ther (2003) 305: 507-14 [PMID:12606634]; J Neurophysiol (2003) 90: 693-702 [PMID:12702704]; Biochem Biophys Res Commun (2001) 280: 976-81 [PMID:11162621]; FEBS Lett (2002) 526: 11-4 [PMID:12208495]; Cell Signal (2008) 20: 1651-61 [PMID:18599270] |
| ChEMBL | Agonist activity against human orexin 2 receptor; EC50; nM | F | 10.09 | pEC50 | 0.08 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 111-113 [PMID:12467628] |
| ChEMBL | Agonist activity against human orexin 2 receptor; EC50; nM | F | 10.09 | pEC50 | 0.08 | nM | EC50 | Bioorg Med Chem Lett (2003) 13: 111-113 [PMID:12467628] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
