tapinarof [Ligand Id: 9686] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL259571 (WBI-1001, Tapinarof, Wbi-1001, GSK2894512, GSK-2894512)
  • Aryl hydrocarbon receptor in Human [GtoPdb: 2951] [UniProtKB: P35869]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Aryl hydrocarbon receptor in Human [GtoPdb: 2951] [UniProtKB: P35869]
GtoPdb Direct binding of tapinarof to the AhR-ARNT heterodimer by fluorescence assay. - 7 pKd 100 nM Kd J. Invest. Dermatol. (2017) 137: 2110-2119 [PMID:28595996]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]