CRV431 [Ligand Id: 11612] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4297487 (Cpi-431, Cpi-431-32, Crv-431, Crv431, CRV-431, CRV431, Rencofilstat) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| peptidylprolyl isomerase A in Human [GtoPdb: 2751] [UniProtKB: P62937] | ||||||||
| GtoPdb | Competitive enzyme inhibition measured in a cyclophilin A isomerase-based assay using recombinant enzyme | - | 8.89 | pKi | 1.3 | nM | Ki | J Pharmacol Exp Ther (2019) 371: 231-241 [PMID:31406003] |
| GtoPdb | - | - | 8.6 | pIC50 | 2.5 | nM | IC50 | J Pharmacol Exp Ther (2019) 371: 231-241 [PMID:31406003] |
| peptidylprolyl isomerase D in Human [GtoPdb: 3179] [UniProtKB: Q08752] | ||||||||
| GtoPdb | - | - | 8.55 | pIC50 | 2.8 | nM | IC50 | J Pharmacol Exp Ther (2019) 371: 231-241 [PMID:31406003] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
