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ChEMBL ligand: CHEMBL57367 (L-759633) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
ChEMBL | Binding affinity against human cannabinoid receptor by using radioligand ([3H]CP-55940) assay. | B | 4.8 | pKi | 15850 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 189-194 |
ChEMBL | Binding affinity to human CB1 receptor | B | 4.8 | pKi | 15850 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
ChEMBL | Displacement of [3H]CP 55940 from human CB1 receptor in cell free system | B | 5.98 | pKi | 1043 | nM | Ki | Eur J Med Chem (2011) 46: 547-555 [PMID:21183257] |
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
ChEMBL | Binding affinity against human Cannabinoid receptor 2 by using radioligand ([3H]CP-55940) assay. | B | 7.7 | pKi | 20 | nM | Ki | Bioorg Med Chem Lett (1996) 6: 189-194 |
ChEMBL | Binding affinity to human CB2 receptor | B | 7.7 | pKi | 20 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
ChEMBL | Displacement of [3H]CP 55940 from human CB2 receptor in cell free system | B | 8.19 | pKi | 6.4 | nM | Ki | Eur J Med Chem (2011) 46: 547-555 [PMID:21183257] |
GtoPdb | - | - | 8.2 | pKi | 6.31 | nM | Ki |
Br J Pharmacol (1999) 126: 665-672 [PMID:10188977]; Bioorg Med Chem Lett (1996) 6: 189-194 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]