ChEMBL ligand: CHEMBL1166 (Acova, Argatroban, Argatroban anhydrous, Argatroban hydrate, Argatroban in dextrose, Argatroban in sodium chloride, Argatroban monohydrate, Argipidine, DK-7419, GN1600, GN-1600, MCI-9038, MD-805)
coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] Thrombin in Bovine [ChEMBL: CHEMBL4471] [UniProtKB: P00735] There should be some charts here, you may need to enable JavaScript!
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750] There should be some charts here, you may need to enable JavaScript!
Trypsin I in Bovine [ChEMBL: CHEMBL3769] [UniProtKB: P00760] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL	Inhibition of human factor 10a	B	4.28	pKi	53000	nM	Ki	Bioorg. Med. Chem. Lett. (2013) 23: 4779-4784 [PMID:23899618]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Binding affinity to thrombin (unknown origin) by surface plasmon resonance analysis	B	8.62	pKd	2.42	nM	Kd	Bioorg. Med. Chem. Lett. (2013) 23: 4779-4784 [PMID:23899618]
ChEMBL	Inhibition of human plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometry	B	7.4	pKi	40	nM	Ki	J Med Chem (2018) 61: 2166-2210 [PMID:28850227]
ChEMBL	Inhibition against clot-associated thrombin.	B	7.41	pKi	39	nM	Ki	J. Med. Chem. (2000) 43: 305-341 [PMID:10669559]
ChEMBL	In vitro binding affinity by measuring the inhibition of human thrombin	B	7.7	pKi	20	nM	Ki	J. Med. Chem. (1994) 37: 3889-3901 [PMID:7966150]
GtoPdb	-	-	7.7	pKi	19	nM	Ki	Thromb Res (1997) 88: 245-50 [PMID:9361377]; Clin Appl Thromb Hemost (2018) 24: 287-294 [PMID:28320219]
ChEMBL	Inhibitory activity against thrombin.	B	7.72	pKi	19	nM	Ki	J. Med. Chem. (2002) 45: 4419-4432 [PMID:12238922]
ChEMBL	Inhibitory activity against human thrombin (using Chromozym TH as the substrate)	B	7.72	pKi	19	nM	Ki	J. Med. Chem. (2000) 43: 1793-1806 [PMID:10794696]
ChEMBL	Inhibition of human alpha-thrombin.	B	8	pKi	10	nM	Ki	J. Med. Chem. (1996) 39: 3039-3043 [PMID:8759623]
ChEMBL	Binding affinity determined against human alpha thrombin	B	8	pKi	9.9	nM	Ki	J. Med. Chem. (2005) 48: 1984-2008 [PMID:15771442]
ChEMBL	Inhibition of human thrombin	B	8.35	pKi	4.5	nM	Ki	Bioorg. Med. Chem. Lett. (2013) 23: 4779-4784 [PMID:23899618]
ChEMBL	In vitro inhibition constant (Ki) against human thrombin	B	8.4	pKi	4	nM	Ki	J. Med. Chem. (2003) 46: 3612-3622 [PMID:12904065]
ChEMBL	Inhibition of thrombin (unknown origin) assessed as fibrin clot formation	B	5.8	pIC50	1580	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 4779-4784 [PMID:23899618]
ChEMBL	Inhibition of thrombin	B	6.22	pIC50	600	nM	IC50	Bioorg. Med. Chem. Lett. (1997) 7: 533-538
ChEMBL	Inhibitory activity against thrombin	B	6.26	pIC50	550	nM	IC50	Bioorg. Med. Chem. Lett. (1999) 9: 1227-1232 [PMID:10340604]
ChEMBL	Inhibitory activity against human thrombin	B	6.48	pIC50	331	nM	IC50	J. Med. Chem. (2005) 48: 7592-7603 [PMID:16302799]
ChEMBL	Inhibition of plasma clot-bound thrombin (unknown origin) using S2238 as substrate	B	7.03	pIC50	92.4	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 4779-4784 [PMID:23899618]
ChEMBL	Inhibitory activity against thrombin induced platelet aggregation	B	7.28	pIC50	52	nM	IC50	J. Med. Chem. (1996) 39: 3039-3043 [PMID:8759623]
ChEMBL	In vitro ability to inhibit the activity of human alpha Thrombin	B	7.41	pIC50	39	nM	IC50	Bioorg. Med. Chem. Lett. (1997) 7: 2205-2210
ChEMBL	In vitro inhibition of thrombin catalytic activity using s-2238 substrate at 10 uM was measured at rat after 3 min incubation with compound	F	7.42	pIC50	38	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 41-44 [PMID:11738569]
ChEMBL	In vitro inhibitory activity against hydrolysis of human alpha thrombin	B	7.42	pIC50	38	nM	IC50	Bioorg. Med. Chem. Lett. (2002) 12: 45-49 [PMID:11738570]
ChEMBL	Inhibition of human thrombin assessed as reduction in release of free nitroaniline using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometer	B	7.93	pIC50	11.7	nM	IC50	Bioorg Med Chem (2017) 25: 458-470 [PMID:27884512]
ChEMBL	Inhibition of free thrombin (unknown origin) using S2238 as substrate	B	7.97	pIC50	10.6	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 4779-4784 [PMID:23899618]
ChEMBL	Inhibition of human thrombin using Ac-FVR-AMC as substrate incubated for 10 mins prior to substrate addition measured for 10 min by fluorescence assay	B	8.02	pIC50	9.46	nM	IC50	Eur. J. Med. Chem. (2015) 96: 122-138 [PMID:25874337]
ChEMBL	Inhibition of human thrombin	B	8.27	pIC50	5.4	nM	IC50	J. Nat. Prod. (2007) 70: 1570-1577 [PMID:17883259]
ChEMBL	Inhibition of human thrombin using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins by spectrophotometer analysis	B	8.41	pIC50	3.88	nM	IC50	Bioorg. Med. Chem. (2015) 23: 7405-7416 [PMID:26537784]
Thrombin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4471] [UniProtKB: P00735]
ChEMBL	Inhibitory activity against bovine thrombin	B	7.07	pKi	85	nM	Ki	J. Med. Chem. (1999) 42: 4584-4603 [PMID:10579821]
ChEMBL	Inhibitory activity against bovine thrombin	B	7.21	pKi	61	nM	Ki	J. Med. Chem. (1999) 42: 4584-4603 [PMID:10579821]
ChEMBL	Inhibition of bovine plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometry	B	7.7	pKi	20	nM	Ki	J Med Chem (2018) 61: 2166-2210 [PMID:28850227]
ChEMBL	Inhibitory activity against thrombin.	B	8.02	pKi	9.6	nM	Ki	J. Med. Chem. (1997) 40: 3091-3099 [PMID:9301673]
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750]
ChEMBL	Inhibition of human t-PA	B	4.06	pKi	87800	nM	Ki	Bioorg. Med. Chem. Lett. (2013) 23: 4779-4784 [PMID:23899618]
Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760]
ChEMBL	Inhibition of bovine trypsin	B	5.54	pKi	2900	nM	Ki	J. Med. Chem. (1996) 39: 3039-3043 [PMID:8759623]
ChEMBL	In vitro ability to inhibit the activity of Trypsin	B	5.3	pIC50	5000	nM	IC50	Bioorg. Med. Chem. Lett. (1997) 7: 2205-2210

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]