ChEMBL ligand: CHEMBL1166 (Acova, Argatroban, Argatroban anhydrous, Argatroban hydrate, Argatroban in dextrose, Argatroban in sodium chloride, Argatroban monohydrate, Argipidine, DK-7419, GN-1600, GN1600, MCI-9038, MD-805)
coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] Thrombin in Bovine [ChEMBL: CHEMBL4471] [UniProtKB: P00735] There should be some charts here, you may need to enable JavaScript!
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750] There should be some charts here, you may need to enable JavaScript!
Trypsin I in Bovine [ChEMBL: CHEMBL3769] [UniProtKB: P00760] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL	Inhibition of human factor 10a	B	4.28	pKi	53000	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4779-4784 [PMID:23899618]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Binding affinity to thrombin (unknown origin) by surface plasmon resonance analysis	B	8.62	pKd	2.42	nM	Kd	Bioorg Med Chem Lett (2013) 23: 4779-4784 [PMID:23899618]
ChEMBL	Inhibition of human plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometry	B	7.4	pKi	40	nM	Ki	J Med Chem (2018) 61: 2166-2210 [PMID:28850227]
ChEMBL	Inhibition against clot-associated thrombin.	B	7.41	pKi	39	nM	Ki	J Med Chem (2000) 43: 305-341 [PMID:10669559]
ChEMBL	In vitro binding affinity by measuring the inhibition of human thrombin	B	7.7	pKi	20	nM	Ki	J Med Chem (1994) 37: 3889-3901 [PMID:7966150]
GtoPdb	-	-	7.7	pKi	19	nM	Ki	Thromb Res (1997) 88: 245-50 [PMID:9361377]; Clin Appl Thromb Hemost (2018) 24: 287-294 [PMID:28320219]
ChEMBL	Inhibitory activity against thrombin.	B	7.72	pKi	19	nM	Ki	J Med Chem (2002) 45: 4419-4432 [PMID:12238922]
ChEMBL	Inhibitory activity against human thrombin (using Chromozym TH as the substrate)	B	7.72	pKi	19	nM	Ki	J Med Chem (2000) 43: 1793-1806 [PMID:10794696]
ChEMBL	Inhibition of human alpha-thrombin.	B	8	pKi	10	nM	Ki	J Med Chem (1996) 39: 3039-3043 [PMID:8759623]
ChEMBL	Binding affinity determined against human alpha thrombin	B	8	pKi	9.9	nM	Ki	J Med Chem (2005) 48: 1984-2008 [PMID:15771442]
ChEMBL	Inhibition of human thrombin	B	8.35	pKi	4.5	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4779-4784 [PMID:23899618]
ChEMBL	In vitro inhibition constant (Ki) against human thrombin	B	8.4	pKi	4	nM	Ki	J Med Chem (2003) 46: 3612-3622 [PMID:12904065]
ChEMBL	Inhibition of thrombin (unknown origin) assessed as fibrin clot formation	B	5.8	pIC50	1580	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4779-4784 [PMID:23899618]
ChEMBL	Inhibition of thrombin	B	6.22	pIC50	600	nM	IC50	Bioorg Med Chem Lett (1997) 7: 533-538
ChEMBL	Inhibitory activity against thrombin	B	6.26	pIC50	550	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1227-1232 [PMID:10340604]
ChEMBL	Inhibitory activity against human thrombin	B	6.48	pIC50	331	nM	IC50	J Med Chem (2005) 48: 7592-7603 [PMID:16302799]
ChEMBL	Inhibition of plasma clot-bound thrombin (unknown origin) using S2238 as substrate	B	7.03	pIC50	92.4	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4779-4784 [PMID:23899618]
ChEMBL	Inhibitory activity against thrombin induced platelet aggregation	B	7.28	pIC50	52	nM	IC50	J Med Chem (1996) 39: 3039-3043 [PMID:8759623]
ChEMBL	In vitro ability to inhibit the activity of human alpha Thrombin	B	7.41	pIC50	39	nM	IC50	Bioorg Med Chem Lett (1997) 7: 2205-2210
ChEMBL	In vitro inhibitory activity against hydrolysis of human alpha thrombin	B	7.42	pIC50	38	nM	IC50	Bioorg Med Chem Lett (2002) 12: 45-49 [PMID:11738570]
ChEMBL	In vitro inhibition of thrombin catalytic activity using s-2238 substrate at 10 uM was measured at rat after 3 min incubation with compound	F	7.42	pIC50	38	nM	IC50	Bioorg Med Chem Lett (2002) 12: 41-44 [PMID:11738569]
ChEMBL	Inhibition of human thrombin assessed as reduction in release of free nitroaniline using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins followed by substrate addition by spectrophotometer	B	7.93	pIC50	11.7	nM	IC50	Bioorg Med Chem (2017) 25: 458-470 [PMID:27884512]
ChEMBL	Inhibition of free thrombin (unknown origin) using S2238 as substrate	B	7.97	pIC50	10.6	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4779-4784 [PMID:23899618]
ChEMBL	Inhibition of thrombin in human blood using fluorogenic Ac-FVR-AMC as substrate incubated for 10 mins by fluorescence based microplate reader method	B	8.02	pIC50	9.46	nM	IC50	Eur J Med Chem (2022) 228: 114035-114035 [PMID:34902735]
ChEMBL	Inhibition of human thrombin using Ac-FVR-AMC as substrate incubated for 10 mins prior to substrate addition measured for 10 min by fluorescence assay	B	8.02	pIC50	9.46	nM	IC50	Eur J Med Chem (2015) 96: 122-138 [PMID:25874337]
ChEMBL	Inhibition of human thrombin	B	8.27	pIC50	5.4	nM	IC50	J Nat Prod (2007) 70: 1570-1577 [PMID:17883259]
ChEMBL	Inhibition of human thrombin using tosyl-glycyl-prolyl-arginine-4-nitranilide acetate as substrate preincubated for 10 mins by spectrophotometer analysis	B	8.41	pIC50	3.88	nM	IC50	Bioorg Med Chem (2015) 23: 7405-7416 [PMID:26537784]
Thrombin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4471] [UniProtKB: P00735]
ChEMBL	Inhibitory activity against bovine thrombin	B	7.07	pKi	85	nM	Ki	J Med Chem (1999) 42: 4584-4603 [PMID:10579821]
ChEMBL	Inhibitory activity against bovine thrombin	B	7.21	pKi	61	nM	Ki	J Med Chem (1999) 42: 4584-4603 [PMID:10579821]
ChEMBL	Inhibition of bovine plasma thrombin using chromogenix AB as substrate after 30 secs by UV-spectrophotometry	B	7.7	pKi	20	nM	Ki	J Med Chem (2018) 61: 2166-2210 [PMID:28850227]
ChEMBL	Inhibitory activity against thrombin.	B	8.02	pKi	9.6	nM	Ki	J Med Chem (1997) 40: 3091-3099 [PMID:9301673]
plasminogen activator, tissue type/Tissue-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1873] [GtoPdb: 2392] [UniProtKB: P00750]
ChEMBL	Inhibition of human t-PA	B	4.06	pKi	87800	nM	Ki	Bioorg Med Chem Lett (2013) 23: 4779-4784 [PMID:23899618]
Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760]
ChEMBL	Inhibition of bovine trypsin	B	5.54	pKi	2900	nM	Ki	J Med Chem (1996) 39: 3039-3043 [PMID:8759623]
ChEMBL	In vitro ability to inhibit the activity of Trypsin	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem Lett (1997) 7: 2205-2210

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]