plasminogen activator, tissue type | S1: Chymotrypsin | IUPHAR/BPS Guide to PHARMACOLOGY

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plasminogen activator, tissue type

Target not currently curated in GtoImmuPdb

Target id: 2392

Nomenclature: plasminogen activator, tissue type

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 562 8p11.21 PLAT plasminogen activator, tissue type
Mouse - 559 8 A2 Plat plasminogen activator
Rat - 559 16q12.5 Plat plasminogen activator
Previous and Unofficial Names
PATISS | tPA | plasminogen activator
Database Links
Specialist databases
MEROPS S01.232 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
Dup-714 Hs Inhibition 8.2 pKi 1
pKi 8.2 (Ki 5.7x10-9 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Hyperfibrinolysis, familial, due to increased release of tissue plasminogen activator
OMIM: 612348


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1. Galemmo RA Jr., Fevig JM, Carini DJ, Cacciola J, Wells BL, Hillyer GL, Buriak J Jr., Rossi KA, Stouten PFW, Alexander RS et al.. (1996) (N-acyl-N-alkyl)glycyl borolysine analogs: A new class of potent thrombin inhibitors. Bioorg. Med. Chem. Lett., 6 (24): 2913–2918.

How to cite this page

S1: Chymotrypsin: plasminogen activator, tissue type. Last modified on 29/01/2016. Accessed on 25/05/2020. IUPHAR/BPS Guide to PHARMACOLOGY,