Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	562	8p11.21	PLAT	plasminogen activator, tissue type
Mouse	-	559	8 11.42 cM	Plat	plasminogen activator, tissue
Rat	-	559	16q12.5	Plat	plasminogen activator, tissue type

Previous and Unofficial Names

PATISS | tPA | plasminogen activator

Database Links
Specialist databases
MEROPS	S01.232 (Hs)
Other databases
Alphafold	P00750 (Hs), P11214 (Mm), P19637 (Rn)
BRENDA	3.4.21.68
ChEMBL Target	CHEMBL1873 (Hs), CHEMBL3259492 (Mm)
DrugBank Target	P00750 (Hs)
Ensembl Gene	ENSG00000104368 (Hs), ENSMUSG00000031538 (Mm), ENSRNOG00000019018 (Rn)
Entrez Gene	5327 (Hs), 18791 (Mm), 25692 (Rn)
Human Protein Atlas	ENSG00000104368 (Hs)
KEGG Enzyme	3.4.21.68
KEGG Gene	hsa:5327 (Hs), mmu:18791 (Mm), rno:25692 (Rn)
OMIM	173370 (Hs)
Pharos	P00750 (Hs)
RefSeq Nucleotide	NM_033011 (Hs), NM_000930 (Hs), NM_008872 (Mm), NM_013151 (Rn)
RefSeq Protein	NP_127509 (Hs), NP_000921 (Hs), NP_032898 (Mm), NP_037283 (Rn)
UniProtKB	P00750 (Hs), P11214 (Mm), P19637 (Rn)
Wikipedia	PLAT (Hs)

Enzyme Reaction
EC Number: 3.4.21.68

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference Dup-714 Hs Inhibition 8.2 pKi 1 ⤷ pKi 8.2 (Ki 5.7x10-9 M) [1]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Hyperfibrinolysis, familial, due to increased release of tissue plasminogen activator OMIM: 612348