DRB [Ligand Id: 5178] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL375530 (5,6-Dichlorobenzimidazole Riboside, Dichlororibobenzimidazole) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Casein kinase 2 in Bovine (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3988628] [UniProtKB: P67868, P68399] | ||||||||
| ChEMBL | Inhibition of calf thymus CK2 using casein as substrate in presence of [gamma-32P]-ATP or [gamma-32P]-GTP | B | 4.89 | pIC50 | 13000 | nM | IC50 | US-20130225674-A1. Use of dibenzofuranone derivatives to inhibit kinases (2013) |
| casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
| ChEMBL | Inhibition of CK2 (unknown origin) | B | 4.64 | pKi | 23000 | nM | Ki | Eur J Med Chem (2016) 115: 148-160 [PMID:27017545] |
| casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
| ChEMBL | Inhibitory constant against Zea mays CK2alpha | B | 5.35 | pKi | 4500 | nM | Ki | Biochem J (2003) 374: 639-646 [PMID:12816539] |
| ChEMBL | Inhibition of GST-fused human recombinant CK2alpha expressed in Escherichia coli HMS174 (DE3) | B | 4.89 | pIC50 | 13000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 2920-2923 [PMID:19414254] |
| casein kinase 2, beta polypeptide subunit/Casein kinase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2358] [GtoPdb: 1551] [UniProtKB: P67870] | ||||||||
| ChEMBL | Binding affinity to CK2beta (unknown origin) using casein as substrate in presence of [gamma-32p]-GTP by liquid scintillation counter analysis | B | 4.64 | pKi | 23000 | nM | Ki | J Med Chem (2023) 66: 2257-2281 [PMID:36745746] |
| cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] | ||||||||
| ChEMBL | Inhibition of CDK9/Cyclin T (1 to 330 amino acid residues) (unknown origin) by differential scanning fluorimetry assay | B | 6.47 | pKi | 340 | nM | Ki | J Med Chem (2013) 56: 660-670 [PMID:23252711] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] | ||||||||
| ChEMBL | Inhibition of CDK2/Cyclin A (174 to 432 amino acid residues) (unknown origin) by differential scanning fluorimetry assay | B | 4.19 | pKi | 65000 | nM | Ki | J Med Chem (2013) 56: 660-670 [PMID:23252711] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
