Synonyms: Avodart® | GG-745 | GI-198745
dutasteride is an approved drug (FDA (2001))
Compound class:
Synthetic organic
Comment: Dutasteride is a synthetic androstane steroid that acts as a 5α-reductase inhibitor. It inhibits conversion of testosterone to dihydrotestosterone (DHT). There are three 5α-reductase isozymes: SRD5A1, SRD5A2 and SRD5A3, all of which are inhibited by dutasteride [1-2].
![]() View more information in the IUPHAR Pharmacology Education Project: dutasteride |
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Classification ![]() |
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Compound class | Synthetic organic |
Approved drug? | Yes. FDA (2001) |
IUPAC Name ![]() |
(1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide |
International Nonproprietary Names ![]() |
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INN number | INN |
7586 | dutasteride |
Synonyms ![]() |
Avodart® | GG-745 | GI-198745 |
Database Links ![]() |
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CAS Registry No. | 164656-23-9 |
ChEBI | CHEBI:521033 |
ChEMBL Ligand | CHEMBL1200969 |
DrugBank Ligand | DB01126 |
DrugCentral Ligand | 973 |
GtoPdb PubChem SID | 187051760 |
PubChem CID | 6918296 |
Search Google for chemical match using the InChIKey | JWJOTENAMICLJG-QWBYCMEYSA-N |
Search Google for chemicals with the same backbone | JWJOTENAMICLJG |
Search PubMed clinical trials | dutasteride |
Search PubMed titles | dutasteride |
Search PubMed titles/abstracts | dutasteride |
UniChem Compound Search for chemical match using the InChIKey | JWJOTENAMICLJG-QWBYCMEYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | JWJOTENAMICLJG-QWBYCMEYSA-N |
Wikipedia | Dutasteride |
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Dutasteride (links to external site)
Cat. No. HY-13613 |