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ChEMBL ligand: CHEMBL27673 (Methoctramine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of acetylcholinesterase (AChE) of human erythrocytes | B | 5.27 | pIC50 | 5370.32 | nM | IC50 | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
ChEMBL | Inhibitory concentration against acetylcholinesterase from human erythrocytes | B | 5.27 | pIC50 | 5370.32 | nM | IC50 | J Med Chem (2003) 46: 954-966 [PMID:12620072] |
ChEMBL | Inhibitory activity on Acetylcholinesterase (AChE) from human erythrocytes | B | 5.27 | pIC50 | 5370.32 | nM | IC50 | J Med Chem (2002) 45: 3286-3295 [PMID:12109912] |
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
ChEMBL | Inhibition of Butyrylcholinesterase (BChE) of human erythrocytes [-log IC50 (uM)] | B | 6.01 | pIC50 | 977.24 | nM | IC50 | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
ChEMBL | Inhibitory concentration against butyrylcholinesterase from human serum | B | 6.01 | pIC50 | 977.24 | nM | IC50 | J Med Chem (2003) 46: 954-966 [PMID:12620072] |
GluN1/GluN2A/Glutamate NMDA receptor; GRIN1/GRIN2A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907604] [GtoPdb: 455, 456] [UniProtKB: Q05586, Q12879] | ||||||||
ChEMBL | Antagonist activity at recombinant GluN1/GluN2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glycine/glutamate-induced inward current at -70mV by two-electrode voltage clamp assay | B | 6.86 | pIC50 | 138 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3901-3904 [PMID:23692871] |
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
ChEMBL | Antagonistic potency against Muscarinic acetylcholine receptor M1 (10 uM) | F | 6.85 | pKd | 141.25 | nM | Kd | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
ChEMBL | Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M1 expressed in CHO cells | B | 7.08 | pKi | 83.18 | nM | Ki | Bioorg Med Chem (2007) 15: 2312-2321 [PMID:17276075] |
GtoPdb | - | - | 7.3 | pKi | - | - | - |
Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038]; J Recept Signal Transduct Res (1997) 17: 177-84 [PMID:9029489]; J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]; Br J Pharmacol (1997) 120: 1409-18 [PMID:9113359] |
ChEMBL | Affinity for human M1 cloned muscarinic receptor subtype expressed in CHO-K1 cells | B | 7.3 | pKi | 49.8 | nM | Ki | J Med Chem (2001) 44: 4035-4038 [PMID:11708906] |
M1 receptor/Muscarinic acetylcholine receptor M1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL276] [GtoPdb: 13] [UniProtKB: P08482] | ||||||||
ChEMBL | Binding affinity for rat cortex Muscarinic acetylcholine receptor M1 | B | 7.38 | pKi | 41.69 | nM | Ki | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
ChEMBL | Affinity constant measured against M1 muscarinic receptor in rat cortex | B | 7.43 | pKi | 37.15 | nM | Ki | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
ChEMBL | Tested for affinity constant against M1 muscarinic receptor in rat cortex using [3H]pirenzepine | B | 7.43 | pKi | 37.15 | nM | Ki | J Med Chem (1994) 37: 3363-3372 [PMID:7932564] |
ChEMBL | Inhibition of binding of [3H]pirenzepine to muscarinic receptor (M1) in rat cortex homogenates | B | 7.43 | pKi | 37.15 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 785-790 |
GtoPdb | - | - | 7.8 | pKi | - | - | - | Mol Pharmacol (1989) 35: 469-76 [PMID:2704370] |
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
ChEMBL | Antagonist potency against carbachol induced inhibition of electrically stimulated guinea pig atria Muscarinic acetylcholine receptor | F | 7.71 | pKd | 19.5 | nM | Kd | J Med Chem (1989) 32: 79-84 [PMID:2909747] |
ChEMBL | Antagonistic activity measured in isolated guinea pig left atrium (M2 receptor) | F | 7.82 | pKd | 15.14 | nM | Kd | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
ChEMBL | Antagonistic activity against M2 muscarinic receptor in guinea pig left atrium derived by plotting log(DR - 1) vs log[antagonist] | F | 7.82 | pKd | 15.14 | nM | Kd | J Med Chem (1994) 37: 3363-3372 [PMID:7932564] |
ChEMBL | Antagonist affinity evaluated against Muscarinic acetylcholine receptor M2 in isolated guinea pig left atrium | F | 7.91 | pKd | 12.3 | nM | Kd | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
ChEMBL | Antagonistic potency against Muscarinic acetylcholine receptor M2 | F | 7.92 | pKd | 12.02 | nM | Kd | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
ChEMBL | Displacement of radiolabeled methoctramine from human muscarinic M2 receptor | B | 7.44 | pKi | 36 | nM | Ki | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
ChEMBL | Displacement of [3H]AF-DX384 from human recombinant M2 receptor expressed in CHO cells | B | 7.57 | pKi | 27 | nM | Ki | J Med Chem (2014) 57: 4543-4557 [PMID:24805037] |
ChEMBL | Binding affinity to human muscarinic M2 receptor by radioligand displacement assay | B | 7.59 | pKi | 26 | nM | Ki | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
ChEMBL | Affinity for human muscarinic acetylcholine receptor M2 expressed in CHO-K1 cells | B | 7.84 | pKi | 14.3 | nM | Ki | J Med Chem (2001) 44: 4035-4038 [PMID:11708906] |
GtoPdb | - | - | 8.4 | pKi | - | - | - |
Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038]; Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]; J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790]; J Pharmacol Exp Ther (2006) 316: 279-88 [PMID:16188951]; J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]; Br J Pharmacol (1997) 120: 1409-18 [PMID:9113359] |
ChEMBL | Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M2 expressed in CHO cells | B | 8.62 | pKi | 2.4 | nM | Ki | Bioorg Med Chem (2007) 15: 2312-2321 [PMID:17276075] |
ChEMBL | Displacement of radiolabeled methoctramine from human muscarinic M2 receptor | B | 7.29 | pIC50 | 51 | nM | IC50 | J Med Chem (2008) 51: 7094-7098 [PMID:18983139] |
ChEMBL | Binding affinity to human muscarinic M2 receptor by radioligand displacement assay | B | 7.43 | pIC50 | 37 | nM | IC50 | Eur J Med Chem (2013) 63: 85-94 [PMID:23466604] |
ChEMBL | Percent inhibition against Muscarinic acetylcholine receptor M2 at 1 uM | B | 7.47 | pIC50 | 34 | nM | IC50 | J Med Chem (2005) 48: 6887-6896 [PMID:16250647] |
Muscarinic acetylcholine receptor M2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4781] [UniProtKB: P06199] | ||||||||
ChEMBL | Ability to dissociate radioligand [3H]NMS from muscarinic acetylcholine receptor M2 of porcine heart | B | 5.52 | pEC50 | 2999.16 | nM | EC50 | J Med Chem (2003) 46: 1390-1407 [PMID:12672239] |
M2 receptor/Muscarinic acetylcholine receptor M2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980] | ||||||||
GtoPdb | - | - | 7.3 | pKi | - | - | - | J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790] |
ChEMBL | Inhibition of [3H]NMS binding to rat heart Muscarinic acetylcholine receptor M2 | B | 7.7 | pKi | 19.95 | nM | Ki | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
ChEMBL | Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M2 using [3H]NMS from rat heart | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (1998) 41: 1557-1560 [PMID:9572880] |
ChEMBL | Affinity constant measured against M2 muscarinic receptor in rat heart | B | 7.84 | pKi | 14.45 | nM | Ki | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
ChEMBL | Tested for affinity constant against M2 muscarinic receptor rat heart using [3H]-NMS | B | 7.84 | pKi | 14.45 | nM | Ki | J Med Chem (1994) 37: 3363-3372 [PMID:7932564] |
ChEMBL | Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M2) in rat heart homogenates | B | 7.84 | pKi | 14.45 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 785-790 |
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
ChEMBL | Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M3 expressed in CHO cells | B | 6.28 | pKi | 524.81 | nM | Ki | Bioorg Med Chem (2007) 15: 2312-2321 [PMID:17276075] |
ChEMBL | Affinity for human M3 cloned muscarinic receptor subtype expressed in CHO-K1 cells | B | 6.56 | pKi | 277 | nM | Ki | J Med Chem (2001) 44: 4035-4038 [PMID:11708906] |
GtoPdb | - | - | 6.9 | pKi | - | - | - |
Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038]; Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]; J Recept Signal Transduct Res (1997) 17: 177-84 [PMID:9029489]; J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]; Br J Pharmacol (1997) 120: 1409-18 [PMID:9113359] |
M3 receptor/Muscarinic acetylcholine receptor M3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL320] [GtoPdb: 15] [UniProtKB: P08483] | ||||||||
ChEMBL | Affinity constant measured against M3 muscarinic receptor in rat submaxillary gland | B | 5.96 | pKi | 1096.48 | nM | Ki | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
ChEMBL | Tested for affinity constant against M3 muscarinic receptor in rat submaxillary gland using [3H]NMS | B | 5.96 | pKi | 1096.48 | nM | Ki | J Med Chem (1994) 37: 3363-3372 [PMID:7932564] |
ChEMBL | Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M3) in rat submaxillary gland homogenates | B | 5.96 | pKi | 1096.48 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 785-790 |
ChEMBL | Compound was tested for its binding affinity towards Muscarinic acetylcholine receptor M3 using [3H]NMS from rat submaxillary gland | B | 6 | pKi | 998 | nM | Ki | J Med Chem (1998) 41: 1557-1560 [PMID:9572880] |
ChEMBL | Inhibition of [3H]NMS binding to rat submaxillary gland Muscarinic acetylcholine receptor M3 | B | 6.02 | pKi | 954.99 | nM | Ki | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
Muscarinic acetylcholine receptor M3 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5498] [UniProtKB: Q8VH26] | ||||||||
ChEMBL | Antagonistic potency against Muscarinic acetylcholine receptor M3 (10 uM) | F | 6.06 | pKd | 870.96 | nM | Kd | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
ChEMBL | Antagonist potency against carbachol induced contractions of isolated guinea pig ileum Muscarinic acetylcholine receptor | F | 6.08 | pKd | 831.76 | nM | Kd | J Med Chem (1989) 32: 79-84 [PMID:2909747] |
ChEMBL | Antagonistic activity measured in isolated guinea pig left ileum (M3 receptor) | F | 6.32 | pKd | 478.63 | nM | Kd | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
ChEMBL | Antagonistic activity against M3 muscarinic receptor in guinea pig left ileum derived by plotting log(DR - 1) vs log[antagonist] | F | 6.32 | pKd | 478.63 | nM | Kd | J Med Chem (1994) 37: 3363-3372 [PMID:7932564] |
ChEMBL | Antagonist affinity evaluated against Muscarinic acetylcholine receptor M3 in isolated guinea pig longitudinal Ileum. | F | 6.44 | pKd | 363.08 | nM | Kd | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
ChEMBL | Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M4 expressed in CHO cells | B | 6.97 | pKi | 107.15 | nM | Ki | Bioorg Med Chem (2007) 15: 2312-2321 [PMID:17276075] |
ChEMBL | Affinity for human M4 cloned muscarinic receptor subtype expressed in CHO-K1 cells | B | 7.42 | pKi | 38 | nM | Ki | J Med Chem (2001) 44: 4035-4038 [PMID:11708906] |
GtoPdb | - | - | 7.5 | pKi | - | - | - |
Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038]; Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]; J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]; Br J Pharmacol (1997) 120: 1409-18 [PMID:9113359] |
M4 receptor/Muscarinic acetylcholine receptor M4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL317] [GtoPdb: 16] [UniProtKB: P08485] | ||||||||
ChEMBL | Inhibition of NG 108-15 binding to Muscarinic acetylcholine receptor M4 | B | 7.49 | pKi | 32.36 | nM | Ki | J Med Chem (1998) 41: 4150-4160 [PMID:9767650] |
ChEMBL | Affinity constant measured against M4 muscarinic receptor rat NG108-15 cells | B | 7.58 | pKi | 26.3 | nM | Ki | J Med Chem (1993) 36: 3734-3737 [PMID:8246244] |
ChEMBL | Inhibition of binding of [3H]N-methylscopolamine to Muscarinic acetylcholine receptor M4 in NG 108-15 cell homogenates | B | 7.58 | pKi | 26.3 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 785-790 |
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
ChEMBL | Displacement of [3H] N-methyl-scopolamine chloride from human muscarinic receptor M5 expressed in CHO cells | B | 6.26 | pKi | 549.54 | nM | Ki | Bioorg Med Chem (2007) 15: 2312-2321 [PMID:17276075] |
ChEMBL | Affinity for human muscarinic acetylcholine receptor M5 subtype expressed in CHO-K1 cells | B | 6.5 | pKi | 313 | nM | Ki | J Med Chem (2001) 44: 4035-4038 [PMID:11708906] |
GtoPdb | - | - | 7.2 | pKi | - | - | - |
Biochem Pharmacol (1996) 52: 643-58 [PMID:8759038]; Mol Pharmacol (1989) 35: 469-76 [PMID:2704370]; J Pharmacol Exp Ther (1991) 256: 727-33 [PMID:1994002]; Br J Pharmacol (1997) 120: 1409-18 [PMID:9113359] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]