A-71623 [Ligand Id: 858] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL323521
  • CCK1 receptor/Cholecystokinin A receptor in Human [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238]
  • CCK1 receptor/Cholecystokinin A receptor in Rat [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
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  • CCK2 receptor/Cholecystokinin B receptor in Rat [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CCK1 receptor/Cholecystokinin A receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238]
ChEMBL Inhibitory activity against cholecystokinin type A receptor from bovine striatal binding assay B 5.72 pIC50 1900 nM IC50 J. Med. Chem. (1992) 35: 4249-4252 [PMID:1433225]
CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551]
ChEMBL Inhibition of [125I]BH-CCK-8 binding to Cholecystokinin type A receptor of rat pancreatic tissue B 9.52 pKi 0.3 nM Ki J. Med. Chem. (2000) 43: 2350-2355 [PMID:10882360]
GtoPdb - - 8.4 pIC50 3.98 nM IC50 Am. J. Physiol. (1992) 263: R125-35 [PMID:1636779]
ChEMBL Inhibitory activity against cholecystokinin type A receptor from rat pancreas binding assay B 10.3 pIC50 0.05 nM IC50 J. Med. Chem. (1992) 35: 4249-4252 [PMID:1433225]
CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553]
ChEMBL Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand B 6.6 pKi 250 nM Ki J. Med. Chem. (2000) 43: 2350-2355 [PMID:10882360]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]