A-71623 [Ligand Id: 858] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL323521 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238] | ||||||||
| ChEMBL | Inhibitory activity against cholecystokinin type A receptor from bovine striatal binding assay | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (1992) 35: 4249-4252 [PMID:1433225] |
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| ChEMBL | Inhibition of [125I]BH-CCK-8 binding to Cholecystokinin type A receptor of rat pancreatic tissue | B | 9.52 | pKi | 0.3 | nM | Ki | J Med Chem (2000) 43: 2350-2355 [PMID:10882360] |
| GtoPdb | - | - | 8.4 | pIC50 | 3.98 | nM | IC50 | Am J Physiol (1992) 263: R125-35 [PMID:1636779] |
| ChEMBL | Inhibitory activity against cholecystokinin type A receptor from rat pancreas binding assay | B | 10.3 | pIC50 | 0.05 | nM | IC50 | J Med Chem (1992) 35: 4249-4252 [PMID:1433225] |
| CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| ChEMBL | Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand | B | 6.6 | pKi | 250 | nM | Ki | J Med Chem (2000) 43: 2350-2355 [PMID:10882360] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
