A-71623 [Ligand Id: 858] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL323521 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CCK1 receptor/Cholecystokinin A receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238] | ||||||||
| ChEMBL | Inhibitory activity against cholecystokinin type A receptor from bovine striatal binding assay | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Med Chem (1992) 35: 4249-4252 [PMID:1433225] |
| CCK1 receptor/Cholecystokinin A receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2871] [GtoPdb: 76] [UniProtKB: P30551] | ||||||||
| ChEMBL | Inhibition of [125I]BH-CCK-8 binding to Cholecystokinin type A receptor of rat pancreatic tissue | B | 9.52 | pKi | 0.3 | nM | Ki | J Med Chem (2000) 43: 2350-2355 [PMID:10882360] |
| GtoPdb | - | - | 8.4 | pIC50 | 3.98 | nM | IC50 | Am J Physiol (1992) 263: R125-35 [PMID:1636779] |
| ChEMBL | Inhibitory activity against cholecystokinin type A receptor from rat pancreas binding assay | B | 10.3 | pIC50 | 0.05 | nM | IC50 | J Med Chem (1992) 35: 4249-4252 [PMID:1433225] |
| CCK2 receptor/Cholecystokinin B receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3508] [GtoPdb: 77] [UniProtKB: P30553] | ||||||||
| ChEMBL | Binding affinity towards Cholecystokinin type B receptor in rat cortex synaptosomes using [125I]BH-CCK-8 as radioligand | B | 6.6 | pKi | 250 | nM | Ki | J Med Chem (2000) 43: 2350-2355 [PMID:10882360] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
