(S)-4C3HPG [Ligand Id: 1374] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL39372
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Human [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
  • mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385]
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  • mGlu2 receptor/Metabotropic glutamate receptor 2 in Human [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416]
  • mGlu2 receptor in Rat [GtoPdb: 290] [UniProtKB: P31421]
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  • mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423]
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  • mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
mGlu1 receptor/Metabotropic glutamate receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3772] [GtoPdb: 289] [UniProtKB: Q13255]
GtoPdb - - 6 pKi - - - Mol Pharmacol (2003) 63: 1082-93 [PMID:12695537];
J Neurochem (2000) 75: 2590-601 [PMID:11080213]
ChEMBL Inhibitory concentration for half maximal inhibition of PI hydrolysis (mGluR1a) B 4.4 pIC50 40000 nM IC50 J Med Chem (1996) 39: 3998-4006 [PMID:8831765]
ChEMBL Antagonist activity at mGlu1 receptor F 4.4 pIC50 40000 nM IC50 J Med Chem (2007) 50: 2563-2568 [PMID:17489573]
mGlu1 receptor/Metabotropic glutamate receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4477] [GtoPdb: 289] [UniProtKB: P23385]
ChEMBL Inhibitory activity against Metabotropic glutamate receptor 1 in the rat LLC-PK1/HEK 293 cells B 4.4 pIC50 40000 nM IC50 J Med Chem (1999) 42: 1546-1555 [PMID:10229625]
mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416]
ChEMBL Agonist activity at mGlu2 receptor F 4.32 pEC50 48000 nM EC50 J Med Chem (2007) 50: 2563-2568 [PMID:17489573]
mGlu2 receptor in Rat [GtoPdb: 290] [UniProtKB: P31421]
GtoPdb - - 4.8 pKi - - - Br J Pharmacol (1998) 123: 497-504 [PMID:9504391]
mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423]
ChEMBL Stimulation of [3H]phosphatidylinositol accumulation by rat Metabotropic glutamate receptor 4 co-expressed with Gqi9 protein in HEK 293 cells; Inactive F 4 pEC50 >100000 nM EC50 J Med Chem (2005) 48: 2534-2547 [PMID:15801843]
mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424]
GtoPdb - - 5.6 pIC50 - - - J Neurochem (2000) 75: 2590-601 [PMID:11080213]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]