PSB-11 [Ligand Id: 5620] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1625681
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
  • A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
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  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
  • A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
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  • A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
  • A2B receptor in Mouse [GtoPdb: 20] [UniProtKB: Q60614]
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  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
  • A3 receptor/Adenosine A3 receptor in Mouse [ChEMBL: CHEMBL1075269] [GtoPdb: 21] [UniProtKB: Q61618]
  • A3 receptor/Adenosine A3 receptor in Rat [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter B 5.79 pKi 1640 nM Ki J Med Chem (2012) 55: 5676-5703 [PMID:22468757]
ChEMBL Displacement of [3H]CCPA from human adenosine receptor A1 expressed in CHO cell membranes incubated for 90 mins by radioligand competition assay B 5.79 pKi 1640 nM Ki Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
GtoPdb - - 5.79 pKi 1640 nM Ki Bioorg Med Chem (2003) 11: 347-56 [PMID:12517430]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL Binding affinity against Adenosine A1 receptor by displacing [3H]CHA radioligand in rat brain cortical membrane B 6.36 pKi 440 nM Ki J Med Chem (2002) 45: 3440-3450 [PMID:12139454]
ChEMBL Displacement of [3H]CCPA from rat adenosine A1 receptor expressed in CHO cells after 60 mins by gamma counter B 6.36 pKi 440 nM Ki J Med Chem (2012) 55: 5676-5703 [PMID:22468757]
ChEMBL Displacement of [3H]CCPA from adenosine receptor A1 in rat brain cortex membranes incubated for 90 mins by radioligand competition assay B 6.36 pKi 440 nM Ki Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
GtoPdb - - 6.36 pKi 440 nM Ki Bioorg Med Chem (2003) 11: 347-56 [PMID:12517430]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
GtoPdb - - 5.89 pKi 1280 nM Ki Bioorg Med Chem (2003) 11: 347-56 [PMID:12517430]
ChEMBL Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter B 5.89 pKi >1280 nM Ki J Med Chem (2012) 55: 5676-5703 [PMID:22468757]
ChEMBL Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assay B 6.97 pKi 108 nM Ki Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL Binding affinity to the adenosine A2A receptor by displacement of [3H]CGS-21680 in rat brain striatal membrane B 5.68 pKi 2100 nM Ki J Med Chem (2002) 45: 3440-3450 [PMID:12139454]
ChEMBL Displacement of [3H]CGS21680 from rat adenosine A2A receptor expressed in CHO cells after 60 mins by gamma counter B 5.68 pKi 2100 nM Ki J Med Chem (2012) 55: 5676-5703 [PMID:22468757]
ChEMBL Displacement of [3H]MSX2 from adenosine receptor A2A in rat brain striatum membranes incubated for 30 mins by radioligand competition assay B 5.68 pKi 2100 nM Ki Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
GtoPdb - - 5.68 pKi 2100 nM Ki Bioorg Med Chem (2003) 11: 347-56 [PMID:12517430]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
ChEMBL Displacement of [3H]PSB-603 from human adenosine receptor A2B expressed in CHO cell membranes incubated for 75 mins by radioligand competition assay B 5.43 pKi 3700 nM Ki Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
A2B receptor in Mouse [GtoPdb: 20] [UniProtKB: Q60614]
GtoPdb - - 5.68 pKi 2100 nM Ki J Med Chem (2002) 45: 3440-50 [PMID:12139454]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
GtoPdb - - 8.31 pKd 4.9 nM Kd Bioorg Med Chem Lett (2002) 12: 501-3 [PMID:11814828]
ChEMBL Binding affinity to human adenosine A3 receptor measured by radioligand binding assay B 5.45 pKi 3510 nM Ki ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351]
GtoPdb - - 8.63 pKi 2.34 nM Ki Bioorg Med Chem (2003) 11: 347-56 [PMID:12517430]
ChEMBL Displacement of [3H]PSB-11 from human adenosine receptor A3 expressed in CHO cell membranes incubated for 60 mins by radioligand competition assay B 8.63 pKi 2.34 nM Ki Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
ChEMBL Binding affinity against human recombinant Adenosine A3 receptor stably expressed in HEK293 cells by displacing [125I]AB-MECA radioligand B 8.64 pKi 2.3 nM Ki J Med Chem (2002) 45: 3440-3450 [PMID:12139454]
ChEMBL Binding affinity to human recombinant A3 adenosine receptor by radioligand binding assay B 8.64 pKi 2.3 nM Ki J Med Chem (2011) 54: 5205-5220 [PMID:21675777]
ChEMBL Displacement of [125I]I-AB-MECA from human recombinant adenosine A3 receptor expressed in CHO cells after 60 mins by gamma counter B 8.64 pKi 2.3 nM Ki J Med Chem (2012) 55: 5676-5703 [PMID:22468757]
A3 receptor/Adenosine A3 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075269] [GtoPdb: 21] [UniProtKB: Q61618]
ChEMBL Binding affinity to mouse adenosine A3 receptor measured by radioligand binding assay B 5.2 pKi 6360 nM Ki ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351]
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
ChEMBL Displacement of [3H]NECA from rat adenosine receptor A3 expressed in CHO cell membranes incubated for 60 mins by radioligand competition assay B 5 pKi >10000 nM Ki Eur J Med Chem (2020) 186: 111879-111879 [PMID:31780082]
ChEMBL Binding affinity to rat adenosine A3 receptor measured by radioligand binding assay B 5 pKi >10000 nM Ki ACS Med Chem Lett (2022) 13: 623-631 [PMID:35450351]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]