reglitazar [Ligand Id: 2670] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL293526 (JT-501, JTT-501, JTT-501.BETA., Reglitazar) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| GtoPdb | - | - | 5.72 | pEC50 | - | - | - | Eur J Pharmacol (1999) 364: 211-9 [PMID:9932726] |
| ChEMBL | Agonist activity for Human PPAR alpha receptor in transcriptional activation assay | F | 5.72 | pEC50 | 1900 | nM | EC50 | J Med Chem (2000) 43: 527-550 [PMID:10691680] |
| ChEMBL | In vitro transcription activation on human peroxisome proliferator activated receptor-alpha (PPAR alpha) | B | 5.72 | pEC50 | 1900 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 3507-3511 [PMID:15177462] |
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2128] [GtoPdb: 593] [UniProtKB: P23204] | ||||||||
| ChEMBL | Agonist activity for murine PPAR alpha receptor in transcriptional activation assay | F | 5.37 | pEC50 | 4300 | nM | EC50 | J Med Chem (2000) 43: 527-550 [PMID:10691680] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Agonist activity for Human PPAR gamma receptor in transcriptional activation assay | F | 7.08 | pEC50 | 83 | nM | EC50 | J Med Chem (2000) 43: 527-550 [PMID:10691680] |
| ChEMBL | In vitro transcription activation on human peroxisome proliferator activated receptor-gamma (PPAR gamma) | B | 7.08 | pEC50 | 83 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 3507-3511 [PMID:15177462] |
| GtoPdb | - | - | 7.1 | pEC50 | - | - | - | Eur J Pharmacol (1999) 364: 211-9 [PMID:9932726] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2459] [GtoPdb: 595] [UniProtKB: P37238] | ||||||||
| ChEMBL | Agonist activity for murine PPAR gamma receptor in transcriptional activation assay | F | 7.05 | pEC50 | 89 | nM | EC50 | J Med Chem (2000) 43: 527-550 [PMID:10691680] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
