macitentan [Ligand Id: 7352] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2103873 (ACT 064992, ACT-064992, Macitentan, Opsumit)
  • ETA receptor/Endothelin receptor ET-A in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
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  • ETB receptor/Endothelin receptor ET-B in Human [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
ChEMBL Antagonist activity at human ETA receptor expressed in CHO cells in presence of ET1 B 8.47 pIC50 3.4 nM IC50 Bioorg Med Chem Lett (2016) 26: 3381-3394 [PMID:27321813]
GtoPdb - - 9.3 pIC50 0.5 nM IC50 J Med Chem (2012) 55: 7849-61 [PMID:22862294]
ChEMBL Displacement of [I125]ET1 from recombinant ETA receptor expressed in CHO cells after 2 hrs by TopCount analysis B 9.3 pIC50 0.5 nM IC50 J. Med. Chem. (2012) 55: 7849-7861 [PMID:22862294]
ChEMBL Displacement of [125I]-ET-1 from human ETA receptor expressed in CHO cell membranes after 2 hrs by scintillation counting B 9.3 pIC50 0.5 nM IC50 Bioorg Med Chem Lett (2016) 26: 3381-3394 [PMID:27321813]
ETB receptor/Endothelin receptor ET-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
ChEMBL Antagonist activity at human ETB receptor expressed in CHO cells in presence of ET1 B 6.01 pIC50 987 nM IC50 Bioorg Med Chem Lett (2016) 26: 3381-3394 [PMID:27321813]
ChEMBL Displacement of [I125]ET1 from recombinant ETB receptor expressed in CHO cells after 2 hrs by TopCount analysis B 6.41 pIC50 391 nM IC50 J. Med. Chem. (2012) 55: 7849-7861 [PMID:22862294]
ChEMBL Displacement of [125I]-ET-1 from human ETB receptor expressed in CHO cell membranes after 2 hrs by scintillation counting B 6.41 pIC50 391 nM IC50 Bioorg Med Chem Lett (2016) 26: 3381-3394 [PMID:27321813]
GtoPdb - - 6.41 pIC50 391 nM IC50 J Med Chem (2012) 55: 7849-61 [PMID:22862294]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]