ChEMBL ligand: CHEMBL2409175
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6] There should be some charts here, you may need to enable JavaScript!
Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
GtoPdb	-	-	8	pIC50	10	nM	IC50	ACS Med Chem Lett (2013) 4: 800-5 [PMID:24900749]
ChEMBL	Inhibition of CK2 in human DLD1 HA-myr-AKT1 cells assessed as suppression of AKTser129 phosphorylation after 3 to 24 hrs by Western blot analysis	B	8.7	pIC50	2	nM	IC50	ACS Med. Chem. Lett. (2016) 7: 300-305 [PMID:26985319]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
GtoPdb	-	-	8	pIC50	10	nM	IC50	ACS Med Chem Lett (2013) 4: 800-5 [PMID:24900749]
ChEMBL	Inhibition of N-terminal His6X-tagged recombinant human full length casein kinase-2alpha expressed in SF21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate preincubated for 20 mins measured after 90 mins by mobility shift assay	B	8.52	pIC50	<3	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 800-805 [PMID:24900749]
ChEMBL	Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 90 mins by mobility shift assay	B	8.52	pIC50	<3	nM	IC50	ACS Med. Chem. Lett. (2016) 7: 300-305 [PMID:26985319]
ChEMBL	Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 mins measured after 90 mins in presence of MgCl2 by caliper mobility shift assay	B	8.52	pIC50	<3	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1336-1341 [PMID:29559278]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of CDK2 (unknown origin)	B	5.14	pIC50	7200	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 800-805 [PMID:24900749]
dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781]
GtoPdb	-	-	7.15	pIC50	70	nM	IC50	ACS Med Chem Lett (2013) 4: 800-5 [PMID:24900749]
ChEMBL	Inhibition of Dyrk-3 (unknown origin)	B	7.15	pIC50	70	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 800-805 [PMID:24900749]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of GSK3beta (unknown origin)	B	5.59	pIC50	2600	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 800-805 [PMID:24900749]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Binding affinity to human ERG expressed in CHO cells by IonWorks assay	B	4.68	pIC50	21000	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 800-805 [PMID:24900749]
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6]
ChEMBL	Inhibition of Hipk-2 (unknown origin)	B	7.4	pIC50	40	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 800-805 [PMID:24900749]
GtoPdb	-	-	7.4	pIC50	40	nM	IC50	ACS Med Chem Lett (2013) 4: 800-5 [PMID:24900749]
Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86]
GtoPdb	-	-	6.82	pIC50	150	nM	IC50	ACS Med Chem Lett (2013) 4: 800-5 [PMID:24900749]
ChEMBL	Inhibition of PIM3 (unknown origin)	B	6.82	pIC50	150	nM	IC50	ACS Med. Chem. Lett. (2013) 4: 800-805 [PMID:24900749]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]