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ChEMBL ligand: CHEMBL2409175 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] | ||||||||
GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-5 [PMID:24900749] |
ChEMBL | Inhibition of CK2 in human DLD1 HA-myr-AKT1 cells assessed as suppression of AKTser129 phosphorylation after 3 to 24 hrs by Western blot analysis | B | 8.7 | pIC50 | 2 | nM | IC50 | ACS Med Chem Lett (2016) 7: 300-305 [PMID:26985319] |
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-5 [PMID:24900749] |
ChEMBL | Inhibition of N-terminal His6X-tagged recombinant human full length casein kinase-2alpha expressed in SF21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate preincubated for 20 mins measured after 90 mins by mobility shift assay | B | 8.52 | pIC50 | <3 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-805 [PMID:24900749] |
ChEMBL | Inhibition of full length N-terminal 6xHis-tagged recombinant human CK2alpha expressed in fall armyworm Sf21 cells using BODIPY-FL-RRRDDDSDDD-CONH2 as substrate after 90 mins by mobility shift assay | B | 8.52 | pIC50 | <3 | nM | IC50 | ACS Med Chem Lett (2016) 7: 300-305 [PMID:26985319] |
ChEMBL | Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 mins measured after 90 mins in presence of MgCl2 by caliper mobility shift assay | B | 8.52 | pIC50 | <3 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1336-1341 [PMID:29559278] |
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
ChEMBL | Inhibition of CDK2 (unknown origin) | B | 5.14 | pIC50 | 7200 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-805 [PMID:24900749] |
dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781] | ||||||||
GtoPdb | - | - | 7.15 | pIC50 | 70 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-5 [PMID:24900749] |
ChEMBL | Inhibition of Dyrk-3 (unknown origin) | B | 7.15 | pIC50 | 70 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-805 [PMID:24900749] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3beta (unknown origin) | B | 5.59 | pIC50 | 2600 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-805 [PMID:24900749] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Binding affinity to human ERG expressed in CHO cells by IonWorks assay | B | 4.68 | pIC50 | 21000 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-805 [PMID:24900749] |
homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6] | ||||||||
ChEMBL | Inhibition of Hipk-2 (unknown origin) | B | 7.4 | pIC50 | 40 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-805 [PMID:24900749] |
GtoPdb | - | - | 7.4 | pIC50 | 40 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-5 [PMID:24900749] |
Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86] | ||||||||
GtoPdb | - | - | 6.82 | pIC50 | 150 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-5 [PMID:24900749] |
ChEMBL | Inhibition of PIM3 (unknown origin) | B | 6.82 | pIC50 | 150 | nM | IC50 | ACS Med Chem Lett (2013) 4: 800-805 [PMID:24900749] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]