PD 174265 [Ligand Id: 6017] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL188762 (PD-174265) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Inhibition of recombinant EGFR by ELISA | B | 8.58 | pIC50 | 2.62 | nM | IC50 | Bioorg Med Chem (2010) 18: 870-879 [PMID:19969465] |
| GtoPdb | - | - | 9.35 | pIC50 | 0.45 | nM | IC50 | Proc Natl Acad Sci USA (1998) 95: 12022-7 [PMID:9751783] |
| ChEMBL | Inhibition of EGFR | B | 9.37 | pIC50 | 0.43 | nM | IC50 | Bioorg Med Chem (2008) 16: 3482-3488 [PMID:18316192] |
| ChEMBL | Inhibition of wild type EGFR by HTRF assay | B | 10 | pIC50 | 0.1 | nM | IC50 | J Med Chem (2010) 53: 2892-2901 [PMID:20222733] |
| Tyrosine-protein kinase SRC in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3655] [UniProtKB: P00523] | ||||||||
| ChEMBL | Activity of wild type chicken N-terminal His-tagged cSrc expressed in Escherichia coli BL21 (DE3) at 10 uM | B | 4.35 | pKd | 45000 | nM | Kd | J Med Chem (2009) 52: 3915-3926 [PMID:19462975] |
| ChEMBL | Inhibition of drug-resistant chicken cSrc double mutant expressed in Escherichia coli | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2008) 16: 3482-3488 [PMID:18316192] |
| ChEMBL | Inhibition of chicken cSrc single mutant expressed in Escherichia coli | B | 5.19 | pIC50 | 6400 | nM | IC50 | Bioorg Med Chem (2008) 16: 3482-3488 [PMID:18316192] |
| ChEMBL | Inhibition of wild type chicken N-terminal His-tagged cSrc expressed in Escherichia coli BL21 (DE3) | B | 5.19 | pIC50 | 6400 | nM | IC50 | J Med Chem (2009) 52: 3915-3926 [PMID:19462975] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
