2-arachidonyl glyceryl ether | Ligand Activity Charts

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2-arachidonyl glyceryl ether
Ligand Activity Charts

2-arachidonyl glyceryl ether [Ligand Id: 5545] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL146346 (HU-310)
CB₁ receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] CB₁ receptor/Cannabinoid CB1 receptor in Rat [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] There should be some charts here, you may need to enable JavaScript!
CB₂ receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] There should be some charts here, you may need to enable JavaScript!
GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CB₁ receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL	Displacement of [3H]-CP55940 from human CB1 receptor expressed in HEK-293-EBNA cell membranes after 90 mins by scintillation counting	B	7.6	pKi	25	nM	Ki	J Med Chem (2011) 54: 5265-5269 [PMID:21675776]
ChEMBL	Displacement of [3H]CP55940 from human CB1 receptor expressed in human HEK293 cells	B	7.7	pKi	20	nM	Ki	J Med Chem (2011) 54: 8278-8288 [PMID:22044209]
CB₁ receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272]
ChEMBL	Binding affinity for cannabinoid receptor 1	B	7.68	pKi	21	nM	Ki	J Med Chem (2005) 48: 5059-5087 [PMID:16078824]
ChEMBL	Displacement of [3H]HU-243 from CB1 receptor of rat brain synaptosomal membranes	B	7.68	pKi	21	nM	Ki	J Med Chem (2013) 56: 8224-8256 [PMID:23865723]
CB₂ receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL	Displacement of [3H]CP55940 from human CB2 receptor expressed in human HEK293 cells	B	5.52	pKi	>3000	nM	Ki	J Med Chem (2011) 54: 8278-8288 [PMID:22044209]
ChEMBL	Binding affinity to human CB2 receptor	B	5.52	pKi	3000	nM	Ki	J Med Chem (2013) 56: 8224-8256 [PMID:23865723]
ChEMBL	Displacement of [3H]-CP55940 from human CB2 receptor expressed in HEK-293-EBNA cell membranes after 90 mins by scintillation counting	B	6	pKi	>1000	nM	Ki	J Med Chem (2011) 54: 5265-5269 [PMID:21675776]
GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6]
GtoPdb	-	-	8	pEC50	10	nM	EC50	Br J Pharmacol (2007) 152: 1092-101 [PMID:17876302]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]