2-arachidonyl glyceryl ether [Ligand Id: 5545] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL146346 (HU-310)
  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
  • CB1 receptor/Cannabinoid CB1 receptor in Rat [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272]
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  • CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
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  • GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Displacement of [3H]-CP55940 from human CB1 receptor expressed in HEK-293-EBNA cell membranes after 90 mins by scintillation counting B 7.6 pKi 25 nM Ki J. Med. Chem. (2011) 54: 5265-5269 [PMID:21675776]
ChEMBL Displacement of [3H]CP55940 from human CB1 receptor expressed in human HEK293 cells B 7.7 pKi 20 nM Ki J. Med. Chem. (2011) 54: 8278-8288 [PMID:22044209]
CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272]
ChEMBL Binding affinity for cannabinoid receptor 1 B 7.68 pKi 21 nM Ki J. Med. Chem. (2005) 48: 5059-5087 [PMID:16078824]
ChEMBL Displacement of [3H]HU-243 from CB1 receptor of rat brain synaptosomal membranes B 7.68 pKi 21 nM Ki J. Med. Chem. (2013) 56: 8224-8256 [PMID:23865723]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL Displacement of [3H]CP55940 from human CB2 receptor expressed in human HEK293 cells B 5.52 pKi >3000 nM Ki J. Med. Chem. (2011) 54: 8278-8288 [PMID:22044209]
ChEMBL Binding affinity to human CB2 receptor B 5.52 pKi 3000 nM Ki J. Med. Chem. (2013) 56: 8224-8256 [PMID:23865723]
ChEMBL Displacement of [3H]-CP55940 from human CB2 receptor expressed in HEK-293-EBNA cell membranes after 90 mins by scintillation counting B 6 pKi >1000 nM Ki J. Med. Chem. (2011) 54: 5265-5269 [PMID:21675776]
GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6]
GtoPdb - - 8 pEC50 10 nM EC50 Br. J. Pharmacol. (2007) 152: 1092-101 [PMID:17876302]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]