LHVS [Ligand Id: 9298] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL222649 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
| ChEMBL | Inhibition of human cathepsin B | B | 5.35 | pIC50 | 4504 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| ChEMBL | Inhibition of human recombinant cathepsin B after 10 mins | B | 5.87 | pIC50 | 1360 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| GtoPdb | - | - | 5.87 | pIC50 | 1360 | nM | IC50 | J Biol Chem (2007) 282: 20836-46 [PMID:17535802] |
| ChEMBL | Inhibition of human cathepsin-B | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3140-3144 [PMID:23639544] |
| cathepsin B/Cathepsin B in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5187] [GtoPdb: 2343] [UniProtKB: P10605] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin B | B | 5.89 | pIC50 | 1277 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin B/Cathepsin B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2602] [GtoPdb: 2343] [UniProtKB: P00787] | ||||||||
| ChEMBL | Inhibition of rat liver lysosomal cathepsin B | B | 6.13 | pIC50 | 735 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin G/Cathepsin G in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5622] [GtoPdb: 2348] [UniProtKB: P28293] | ||||||||
| ChEMBL | Inhibition of cathepsin G activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrs | B | 4.4 | pIC50 | 39800 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235] | ||||||||
| ChEMBL | Inhibition of human cathepsin K | B | 8.21 | pIC50 | 6.2 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| ChEMBL | Inhibition of human cathepsin-K | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3140-3144 [PMID:23639544] |
| cathepsin K/Cathepsin K in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075277] [GtoPdb: 2350] [UniProtKB: P55097] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin K | B | 6.41 | pIC50 | 388 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| Cathepsin L in Toxoplasma gondii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295862] [UniProtKB: Q6DMN0] | ||||||||
| ChEMBL | Inhibition of Toxoplasma gondii cathepsin L using Z-L-R-AMC as substrate preincubated for 5 mins followed by substrate addition measured over 5 mins by spectrophotometric method | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1972-1980 [PMID:29650289] |
| cathepsin L/Cathepsin L in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3837] [GtoPdb: 2351] [UniProtKB: P07711] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | J Biol Chem (2007) 282: 20836-46 [PMID:17535802] |
| ChEMBL | Inhibition of human recombinant cathepsin L after 10 mins | B | 8.15 | pIC50 | 7 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| ChEMBL | Inhibition of human cathepsin L | B | 8.24 | pIC50 | 5.7 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| ChEMBL | Inhibition of human cathepsin L using Z-L-R-AMC as substrate preincubated for 5 mins followed by substrate addition measured over 5 mins by spectrophotometric method | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 1972-1980 [PMID:29650289] |
| cathepsin V/Cathepsin L in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2305] [GtoPdb: 2352] [UniProtKB: P07154] | ||||||||
| ChEMBL | Inhibition of rat liver lysosomal cathepsin L | B | 8.39 | pIC50 | 4.1 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin L in Human [GtoPdb: 2351] [UniProtKB: P07711] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | J Biol Chem (2007) 282: 20836-46 [PMID:17535802] |
| cathepsin L/Cathepsin L1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5291] [GtoPdb: 2351] [UniProtKB: P06797] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin L | B | 8.15 | pIC50 | 7.1 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774] | ||||||||
| ChEMBL | Inhibition of human cathepsin-S | B | 8.72 | pIC50 | 1.9 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 3140-3144 [PMID:23639544] |
| ChEMBL | Inhibition of human cathepsin S | B | 8.92 | pIC50 | 1.2 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| GtoPdb | - | - | 9 | pIC50 | 1 | nM | IC50 | J Biol Chem (2007) 282: 20836-46 [PMID:17535802] |
| ChEMBL | Inhibition of human recombinant cathepsin S after 10 mins | B | 9 | pIC50 | 1 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| cathepsin S/Cathepsin S in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4098] [GtoPdb: 2353] [UniProtKB: O70370] | ||||||||
| ChEMBL | Inhibition of mouse recombinant cathepsin S | B | 9.3 | pIC50 | 0.5 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin S/Cathepsin S in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075217] [GtoPdb: 2353] [UniProtKB: Q02765] | ||||||||
| ChEMBL | Inhibition of rat spleen cathepsin S | B | 8.77 | pIC50 | 1.7 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4929-4933 [PMID:17590332] |
| cathepsin C/Dipeptidyl peptidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2252] [GtoPdb: 2344] [UniProtKB: P53634] | ||||||||
| ChEMBL | Inhibition of human recombinant cathepsin C after 10 mins | B | 5 | pIC50 | >10000 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| proteinase 3/Myeloblastin in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5384] [GtoPdb: 2401] [UniProtKB: Q61096] | ||||||||
| ChEMBL | Inhibition of proteinase-3 activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrs | B | 4.67 | pIC50 | 21200 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
| elastase, neutrophil expressed/Neutrophil elastase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5156] [GtoPdb: 2358] [UniProtKB: Q3UP87] | ||||||||
| ChEMBL | Inhibition of neutrophil elastase activation in beta-estradiol differentiated mouse EcoM-G cells after 24 hrs | B | 4.59 | pIC50 | 25500 | nM | IC50 | J Biol Chem (2007) 282: 20836-20846 [PMID:17535802] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
