UFP-112 [Ligand Id: 3917] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL409969 (UFP-112) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from human recombinant delta opioid receptor expressed in in CHO cells | B | 6.37 | pKi | 426.58 | nM | Ki | Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from human recombinant kappa opioid receptor expressed in in CHO cells | B | 8.36 | pKi | 4.37 | nM | Ki | Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from human recombinant mu opioid receptor expressed in in CHO cells | B | 7.13 | pKi | 74.13 | nM | Ki | Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886] |
| NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] | ||||||||
| ChEMBL | Displacement of [3H]N/OFQ from human recombinant NOP receptor expressed in CHO cells | B | 10.55 | pKi | 0.03 | nM | Ki | Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886] |
| GtoPdb | - | - | 9.71 | pEC50 | - | - | - |
Peptides (2007) 28: 1240-51 [PMID:17532097]; Naunyn Schmiedebergs Arch Pharmacol (2009) 379: 599-607 [PMID:19183962] |
| ChEMBL | Agonist activity at human NOP receptor expressed in CHO cells by [35S]GTPgammaS binding assay | F | 10.55 | pEC50 | 0.03 | nM | EC50 | Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886] |
| NOP receptor/Nociceptin receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621] [GtoPdb: 320] [UniProtKB: P35377] | ||||||||
| ChEMBL | Agonist activity at NOP receptor in Swiss mouse vas deferens by [35S]GTP-gamma-S binding assay | F | 9.24 | pEC50 | 0.58 | nM | EC50 | Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886] |
| NOP receptor/Nociceptin receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4503] [GtoPdb: 320] [UniProtKB: P35370] | ||||||||
| ChEMBL | Agonist activity at NOP receptor in Sprague-Dawley rat vas deferens assessed as effect on electrically stimulated contractions | F | 8.34 | pEC50 | 4.57 | nM | EC50 | Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886] |
| Nociceptin receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5492] [UniProtKB: P47748] | ||||||||
| ChEMBL | Agonist activity at NOP receptor in Albino guinea pig ileum assessed as effect on electrically stimulated contractions | F | 9.17 | pEC50 | 0.68 | nM | EC50 | Bioorg Med Chem (2007) 15: 4434-4443 [PMID:17490886] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
