FNDR-20123 [Ligand Id: 11797] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4090165 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC1 using Boc-Lys (Ac)-AMC substrate by fluorescence assay | B | 7.6 | pIC50 | 25 | nM | IC50 | Eur J Med Chem (2017) 135: 174-195 [PMID:28453994] |
| histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC2 using Boc-Lys (Ac)-AMC substrate by fluorescence assay | B | 7.54 | pIC50 | 29 | nM | IC50 | Eur J Med Chem (2017) 135: 174-195 [PMID:28453994] |
| histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC3 using Boc-Lys (Ac)-AMC substrate by fluorescence assay | B | 8.7 | pIC50 | 2 | nM | IC50 | Eur J Med Chem (2017) 135: 174-195 [PMID:28453994] |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Inhibition of recombinant human HDAC8 using Boc-Lys (Ac)-AMC substrate by fluorescence assay | B | 6.55 | pIC50 | 280 | nM | IC50 | Eur J Med Chem (2017) 135: 174-195 [PMID:28453994] |
| ChEMBL | Inhibition of recombinant human HDAC6 using Boc-Lys (Ac)-AMC substrate by fluorescence assay | B | 7.96 | pIC50 | 11 | nM | IC50 | Eur J Med Chem (2017) 135: 174-195 [PMID:28453994] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum TM90C2B [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.88 | pIC50 | 13.26 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite dual gamete formation assay (DGFA) | - | 6.72 | pIC50 | 190 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum K1 [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.72 | pIC50 | 19.05 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum NF54 [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.6 | pIC50 | 25.27 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum 3D7 [GtoPdb: 3072] [UniProtKB: Q7K6A1] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.39 | pIC50 | 41 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum 7G8 [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.84 | pIC50 | 14.36 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
| Plasmodium falciparum histone deacetylase 1 in Plasmodium falciparum Dd2 [GtoPdb: 3072] | ||||||||
| GtoPdb | Parasite growth inhibition assay | - | 7.76 | pIC50 | 17.5 | nM | IC50 | Malar J (2020) 19: 365 [PMID:33046062] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
