baicalein [Ligand Id: 5144] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL8260 (Baicalein, Noroxylin, NSC-661431) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| synuclein alpha/Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840] | ||||||||
| ChEMBL | Inhibition of human alpha-synuclein filament formation expressed in Escherichia coli BL21(DE3) cells incubated for 72 hrs by thioflavin S based fluorescence assay | B | 5.09 | pIC50 | 8200 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| 12S-LOX/Arachidonate 12-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054] | ||||||||
| ChEMBL | Inhibition of human platelet-type 12-lipoxygenase | B | 5.8 | pKi | 1600 | nM | Ki | J Med Chem (2011) 54: 5485-5497 [PMID:21739938] |
| ChEMBL | Inhibition of 12-hLO | B | 6.07 | pIC50 | 860 | nM | IC50 | Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117] |
| 15-LOX-1/Arachidonate 12-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2741] [GtoPdb: 1388] [UniProtKB: Q02759] | ||||||||
| ChEMBL | Inhibitory activity against 12-lipoxygenase in rat platelet rich plasma | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1991) 34: 1503-1505 [PMID:2016727] |
| 15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] | ||||||||
| ChEMBL | Inhibition of human 15-lipoxygenase | B | 6.22 | pKi | 600 | nM | Ki | J Med Chem (2011) 54: 5485-5497 [PMID:21739938] |
| ChEMBL | Inhibition of 15-hLO1 | B | 5.04 | pIC50 | 9100 | nM | IC50 | Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117] |
| 15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] | ||||||||
| ChEMBL | Inhibition of 15-hLO2 | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117] |
| 15-LOX-2/Arachidonate 15-lipoxygenase, type II in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3289] [GtoPdb: 1389] [UniProtKB: Q8K4F2] | ||||||||
| ChEMBL | Inhibitory activity against 15-lipoxygenase in rat polymorphonuclear leukocytes | B | 6.59 | pIC50 | 260 | nM | IC50 | J Med Chem (1991) 34: 1503-1505 [PMID:2016727] |
| 5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
| ChEMBL | In vitro inhibition of LTB4 production was measured in rat blood | F | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (1991) 34: 1028-1036 [PMID:1848292] |
| ChEMBL | Inhibitory activity against 5-lipoxygenase in rat polymorphonuclear leukocytes | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1991) 34: 1503-1505 [PMID:2016727] |
| casein kinase 2, alpha 1 polypeptide subunit/casein kinase 2, beta polypeptide subunit/Casein kinase 2 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3988629] [GtoPdb: 1549, 1551] [UniProtKB: P19139, P67874] | ||||||||
| ChEMBL | Inhibition of rat liver CK2 phosphorylation using RRRADDSDDDDD as substrate in presence of [32p]-ATP | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2023) 66: 2257-2281 [PMID:36745746] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907602] [GtoPdb: 1961] [UniProtKB: P06493, P14635] | ||||||||
| ChEMBL | Inhibition of Cdk1/cyclin B | B | 5.19 | pIC50 | 6530 | nM | IC50 | Bioorg Med Chem (2008) 16: 7128-7133 [PMID:18639462] |
| DNA polymerase eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5542] [UniProtKB: Q9Y253] | ||||||||
| ChEMBL | Inhibition of C-terminal 6xHis-tagged human DNA polymerase eta (1 to 511 residues) expressed in Escherichia coli BL21 DE3 using 5'-IRD700-GCAGGTCGACTCCAAAG-3' primer/ 5'-TCGGTACCGGGTTAGCCTTTGGAGTCGACCTGC-3' template as DNA substrate incubated for 60 mins in presence of Mg2+ by bromophenol blue staining based assay | B | 4.93 | pIC50 | 11800 | nM | IC50 | Eur J Med Chem (2023) 248: 115044-115044 [PMID:36621139] |
| Fructose-1,6-bisphosphatase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3975] [UniProtKB: P09467] | ||||||||
| ChEMBL | Inhibition of human liver FBP1 incubated for 5 mins by fluorescence method | B | 4.54 | pIC50 | 29000 | nM | IC50 | J Nat Prod (2020) 83: 1541-1552 [PMID:32364726] |
| GABAA receptor π subunit/GABAA receptor δ subunit/GABAA receptor α1 subunit/GABAA receptor β1 subunit/GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor α2 subunit/GABAA receptor β2 subunit/GABAA receptor α4 subunit/GABAA receptor ε subunit/GABAA receptor α6 subunit/GABAA receptor γ1 subunit/GABAA receptor γ3 subunit/GABAA receptor θ subunit/GABA-A receptor; anion channel in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2093872] [GtoPdb: 419, 416, 404, 410, 414, 412, 408, 406, 405, 411, 407, 417, 409, 413, 415, 418] [UniProtKB: O00591, O14764, P14867, P18505, P18507, P28472, P31644, P34903, P47869, P47870, P48169, P78334, Q16445, Q8N1C3, Q99928, Q9UN88] | ||||||||
| ChEMBL | Binding affinity towards benzodiazepine site in GABAA receptor | B | 5.25 | pKi | 5623.41 | nM | Ki | J Med Chem (2001) 44: 1883-1891 [PMID:11384234] |
| Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] | ||||||||
| ChEMBL | Competitive inhibition of glucocorticoid receptor (unknown origin) by fluorescence polarization based competition assay | B | 4.72 | pIC50 | 19000 | nM | IC50 | J Nat Prod (2022) 85: 237-247 [PMID:34935393] |
| Glyceraldehyde-3-phosphate dehydrogenase liver in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2284] [UniProtKB: P04406] | ||||||||
| ChEMBL | Inhibition of human recombinant GADPH incubated for 30 mins by absorbance based assay | B | 4.36 | pIC50 | 43930 | nM | IC50 | Bioorg Med Chem (2023) 90: 117362-117362 [PMID:37320992] |
| Glyoxalase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2424] [UniProtKB: Q04760] | ||||||||
| ChEMBL | Inhibition of human recombinant His-tagged Glyoxalase 1 expressed in Sf21-Baculovirus system | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg Med Chem (2008) 16: 3969-3975 [PMID:18258440] |
| GPR35/G-protein coupled receptor 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293267] [GtoPdb: 102] [UniProtKB: Q9HC97] | ||||||||
| ChEMBL | Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins | B | 4.55 | pIC50 | 28200 | nM | IC50 | ACS Med Chem Lett (2012) 3: 165-169 [PMID:24900447] |
| ChEMBL | Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactamase reporter gene assay | F | 4.64 | pEC50 | 22700 | nM | EC50 | ACS Med Chem Lett (2012) 3: 165-169 [PMID:24900447] |
| ChEMBL | Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay | F | 4.99 | pEC50 | 10300 | nM | EC50 | ACS Med Chem Lett (2012) 3: 165-169 [PMID:24900447] |
| G protein-coupled receptor kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6144] [GtoPdb: 1470] [UniProtKB: P43250] | ||||||||
| ChEMBL | Inhibition of human recombinant full-length GST-tagged human GRK6 using peptide substrate peptide-216 incubated for 7 hrs | B | 5.06 | pIC50 | 8700 | nM | IC50 | US-20140309185-A1. Inhibiting G-protein coupled receptor 6 kinase polypeptides (2014) |
| histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] | ||||||||
| ChEMBL | Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate | B | 5.92 | pIC50 | 1204 | nM | IC50 | HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators |
| Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1] | ||||||||
| ChEMBL | Inhibition of recombinant HIV-1 integrase 3'-processing activity using 32P 5' end-labeled linear 21'mer as substrate preincubated for 30 mins prior to substrate challenge by phosphorimaging analysis | B | 5.12 | pIC50 | 7500 | nM | IC50 | Bioorg Med Chem (2014) 22: 3146-3158 [PMID:24794743] |
| ChEMBL | IC50 was measured as concentration required to inhibit 50% of HIV-integrase integration | B | 5.37 | pIC50 | 4300 | nM | IC50 | J Med Chem (1995) 38: 890-897 [PMID:7699704] |
| ChEMBL | Inhibition of His6-tagged HIV-1 integrase assessed as decrease in integrase-Flag-LEDGF/p75 interaction preincubated with enzyme for 30 mins followed by addition of Flag-LEDGF/p75 for 1 hr by AlphaScreen assay | B | 5.57 | pIC50 | 2700 | nM | IC50 | Bioorg Med Chem (2014) 22: 3146-3158 [PMID:24794743] |
| ChEMBL | IC50 was measured as concentration required to inhibit 50% of HIV-integrase cleavage | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (1995) 38: 890-897 [PMID:7699704] |
| ChEMBL | Inhibition of recombinant HIV-1 integrase strand transfer activity using 32P 5' end-labeled linear 21'mer as substrate preincubated for 30 mins prior to substrate challenge by phosphorimaging analysis | B | 6.11 | pIC50 | 780 | nM | IC50 | Bioorg Med Chem (2014) 22: 3146-3158 [PMID:24794743] |
| lysine demethylase 4E/Lysine-specific demethylase 4D-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293226] [GtoPdb: 2679] [UniProtKB: B2RXH2] | ||||||||
| ChEMBL | Non-competitive inhibition of JMJD2E relative to alpha-ketoglutarate | B | 5.36 | pKi | 4330 | nM | Ki | Bioorg Med Chem (2011) 19: 3625-3636 [PMID:21596573] |
| ChEMBL | Inhibition of JMJD2E | B | 5.52 | pIC50 | 3000 | nM | IC50 | Bioorg Med Chem (2011) 19: 3625-3636 [PMID:21596573] |
| ChEMBL | Inhibition of N-terminal His-6-tagged human JMJD2E (1 to 337 residues) expressed in Escherichia coli by MALDI-TOF/MS analysis | B | 5.52 | pIC50 | 3000 | nM | IC50 | Medchemcomm (2012) 3: 135-161 |
| lysine demethylase 1A/Lysine-specific histone demethylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6136] [GtoPdb: 2669] [UniProtKB: O60341] | ||||||||
| ChEMBL | Inhibition of LSD1 (unknown origin) | B | 4.9 | pIC50 | 12500 | nM | IC50 | Bioorg Med Chem (2019) 27: 370-374 [PMID:30552007] |
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in KB/MDR cells | F | 4.39 | pIC50 | 41000 | nM | IC50 | J Med Chem (2004) 47: 5555-5566 [PMID:15481991] |
| Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] | ||||||||
| ChEMBL | Competitive inhibition of progesterone receptor (unknown origin) by fluorescence polarization based competition assay | B | 4.82 | pIC50 | 15000 | nM | IC50 | J Nat Prod (2022) 85: 237-247 [PMID:34935393] |
| prolyl endopeptidase/Prolyl endopeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3202] [GtoPdb: 2395] [UniProtKB: P48147] | ||||||||
| ChEMBL | Inhibition of human brain prolyl oligopeptidase expressed in Escherichia coli | B | 4.44 | pIC50 | 36000 | nM | IC50 | Bioorg Med Chem (2008) 16: 7516-7524 [PMID:18650094] |
| RTP Type S/Receptor-type tyrosine-protein phosphatase S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396508] [GtoPdb: 1866] [UniProtKB: Q13332] | ||||||||
| ChEMBL | Inhibition of recombinant human PTP-sigma (residues 1367 to 1948) using para-nitrophenylphosphate as substrate for 60 mins by fluorescence analysis | B | 4.99 | pIC50 | 10300 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 87-93 [PMID:26602279] |
| Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7] | ||||||||
| ChEMBL | MERS_3CL Pro protease inhibition IC50 by FRET kind of response from peptide substrate | F | 5 | pIC50 | >10000 | nM | IC50 | Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen |
| CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] | ||||||||
| ChEMBL | Binding affinity to SARS-CoV-2 3CL protease at 1.875 to 50 uM by SPR assay | B | 4.5 | pKd | 31300 | nM | Kd | J Nat Prod (2022) 85: 327-336 [PMID:35084181] |
| ChEMBL | Binding affinity to C-terminal GST-tagged full length SARS CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells incubated for 1 hr by ESI-MS assay | B | 4.91 | pKd | 12400 | nM | Kd | J Med Chem (2022) 65: 2716-2746 [PMID:33186044] |
| ChEMBL | Binding affinity to C-terminal GST-tagged full length SARS CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells by isothermal titration calorimetry assay | B | 4.94 | pKd | 11500 | nM | Kd | J Med Chem (2022) 65: 2716-2746 [PMID:33186044] |
| ChEMBL | Inhibition of 6his/TEV-fused GST tagged SARS-CoV-2 MPro (1 to 306 residues) expressed in Escherichia coli RIL cells using 5-FAM-AVLQSGFR-Lys-(Dabcyl)-K-amide as substrate assessed as substrate cleavage preincubated for 30 mins followed by substrate addition and measured every 30 sec for 60 cycles by FRET based assay | B | 4.3 | pIC50 | 50600 | nM | IC50 | J Nat Prod (2023) 86: 264-275 [PMID:36651644] |
| ChEMBL | Inhibition of SARS-CoV-2 MPro using Dabcyl-KTSAVLQSGFRKME-Edans as substrate preincubated for 5 mins followed by substrate addition and measured after 10 mins by fluorescence based assay | B | 5.29 | pIC50 | 5160 | nM | IC50 | J Nat Prod (2023) 86: 264-275 [PMID:36651644] |
| ChEMBL | Inhibition of SARS-CoV-2 3CL protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as flurogenic substrate pre-incubated with compound for 10 mins followed by substrate addition measured after 10 mins by FRET assay | B | 5.29 | pIC50 | 5100 | nM | IC50 | J Nat Prod (2022) 85: 327-336 [PMID:35084181] |
| ChEMBL | Inhibition of C-terminal GST-tagged full length SARS CoV 3CL protease expressed in Escherichia coli BL21 (DE3) cells using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH as substrate incubated for 10 mins by FRET assay | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Med Chem (2022) 65: 2716-2746 [PMID:33186044] |
| ChEMBL | Inhibition of SARS-CoV-2 MPro | B | 6.01 | pIC50 | 980 | nM | IC50 | J Nat Prod (2023) 86: 264-275 [PMID:36651644] |
| ChEMBL | Inhibition of SARS-CoV-2 Main protease expressed in Escherichia coli BL21 (DE3) using fluorogenic peptide Dabcyl-KLSAVLQSGFRKM-Edans-NH2 as substrate incubated for 30 mins by fluorescence resonance energy transfer (FRET)-based enzymatic assay | B | 6.02 | pIC50 | 966 | nM | IC50 | Eur J Med Chem (2023) 257: 115487-115487 [PMID:37257212] |
| ChEMBL | Inhibition of GST-tagged SARS-CoV-2 main protease expressed in Escherichia coli BL21 (De3) using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured for 3.5 mins by FRET analysis | B | 6.03 | pIC50 | 940 | nM | IC50 | Eur J Med Chem (2022) 238: 114508-114508 [PMID:35688005] |
| ChEMBL | Inhibition of SARS-CoV-2 MPro | B | 6.03 | pIC50 | 940 | nM | IC50 | Bioorg Med Chem (2021) 29: 115860-115860 [PMID:33191083] |
| ChEMBL | Inhibition of SARS-CoV-2 (BetaCoV/Wuhan/WIV04/2019) MPro expressed in Escherichia coli using FRET susbtrate measured after 1 hr | B | 6.03 | pIC50 | 940 | nM | IC50 | Bioorg Med Chem (2021) 29: 115860-115860 [PMID:33191083] |
| ChEMBL | Inhibition of C-terminal GST-tagged full length SARS CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH as substrate incubated for 10 mins by FRET assay | B | 6.03 | pIC50 | 940 | nM | IC50 | J Med Chem (2022) 65: 2716-2746 [PMID:33186044] |
| ChEMBL | Inhibition of SARS-CoV-2 main protease | B | 6.03 | pIC50 | 940 | nM | IC50 | Eur J Med Chem (2020) 201: 112559-112559 [PMID:32563814] |
| ChEMBL | Inhibition of N-terminal MBP-tagged SARS CoV-2 Main protease by fluorescence based analysis | B | 6.03 | pIC50 | 940 | nM | IC50 | J Med Chem (2021) 64: 16922-16955 [PMID:34798775] |
| ChEMBL | Inhibition of SARS-CoV-2 MPro | B | 6.03 | pIC50 | 939.72 | nM | IC50 | Bioorg Med Chem (2021) 29: 115860-115860 [PMID:33191083] |
| ChEMBL | Inhibition of full length SARS-CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured every 35 secs for 3.5 mins by FRET assay | B | 6.05 | pIC50 | 900 | nM | IC50 | J Nat Prod (2023) 86: 1536-1549 [PMID:37257024] |
| ChEMBL | Inhibition of N-terminal full length GST-tagged SARS-CoV-2 3CLpro expressed in Escherichia coli BL21 (DE3) by using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH as fluorogenic substrate preincubated with compound for 10 mins followed by substrate addition by FRET assay | B | 6.41 | pIC50 | 390 | nM | IC50 | Eur J Med Chem (2023) 257: 115491-115491 [PMID:37244162] |
| ChEMBL | Inhibition of C-terminal His6-tagged full length SARS CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells using Thr-Ser-Ala-Val-Leu-Gln-pNA substrate preincubated for 30 mins followed by substrate addition by microplate reader analysis | B | 6.47 | pIC50 | 340 | nM | IC50 | J Med Chem (2022) 65: 2716-2746 [PMID:33186044] |
| ChEMBL | SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate | F | 7.7 | pIC50 | 20 | nM | IC50 | Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen |
| ChEMBL | Inhibition of C-terminal GST-tagged full length SARS CoV-2 3CL protease expressed in Escherichia coli BL21 (DE3) cells measured after 48 hrs by qRT-PCR analysis | B | 5.77 | pEC50 | 1690 | nM | EC50 | J Med Chem (2022) 65: 2716-2746 [PMID:33186044] |
| polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
| ChEMBL | Inhibition of PLK1 (unknown origin) in the presence of ATP by ADP-Glo-kinase assay | B | 5.05 | pIC50 | 9000 | nM | IC50 | J Med Chem (2022) 65: 10133-10160 [PMID:35878418] |
| polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4] | ||||||||
| ChEMBL | Inhibition of PLK3 (unknown origin) in the presence of ATP by ADP-Glo-kinase assay | B | 4.4 | pIC50 | 40000 | nM | IC50 | J Med Chem (2022) 65: 10133-10160 [PMID:35878418] |
| Sucrase-isomaltase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2748] [UniProtKB: P14410] | ||||||||
| ChEMBL | Inhibition of sucrase | B | 4.28 | pIC50 | 52000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1659-1662 [PMID:18255289] |
| ChEMBL | Inhibition of human intestinal sucrase in human Caco-2 cell membrane | B | 4.46 | pIC50 | 35000 | nM | IC50 | J Nat Prod (1998) 61: 1413-1415 [PMID:9834167] |
| Sucrase-isomaltase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3114] [UniProtKB: P23739] | ||||||||
| ChEMBL | Inhibition of rat intestinal sucrase | B | 4.28 | pIC50 | 52000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 812-815 [PMID:18039578] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of recombinant FLT3 (unknown origin) by TR-FRET assay | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1768-1770 [PMID:23411073] |
| YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947] | ||||||||
| ChEMBL | Inhibition of YES (unknown origin) | B | 5.48 | pIC50 | 3300 | nM | IC50 | Eur J Med Chem (2019) 166: 186-196 [PMID:30769179] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
| ChEMBL | Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rat Artery myocytes | F | 4.07 | pIC50 | 85100 | nM | IC50 | IC50 data for the L-type calcium channel extracted from a set of literature articles |
| xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989] | ||||||||
| ChEMBL | Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry | B | 5.55 | pIC50 | 2790 | nM | IC50 | J Nat Prod (1998) 61: 71-76 [PMID:9461655] |
| Xanthine dehydrogenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3649] [UniProtKB: P80457] | ||||||||
| ChEMBL | Inhibition of bovine milk xanthine oxidase assessed using xanthine as substrate after 10 mins by fluorometric assay | B | 4.15 | pIC50 | 71500 | nM | IC50 | Eur J Med Chem (2017) 135: 491-516 [PMID:28478180] |
| ChEMBL | Inhibition of cow milk xanthine oxidase | B | 5.48 | pIC50 | 3300 | nM | IC50 | J Nat Prod (1988) 51: 345-348 [PMID:3379415] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
