propranolol [Ligand Id: 564] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL27 (AY-64043-, Betalong, .beta.-propranolol, Dl-propranolol, Euprovasin, Inderal, Inderide-40/25, Inderide-80/25, Propranolol, Proprasylyt, Reducor) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| ChEMBL | Antagonist activity at human wild-type A2A receptor expressed in CHO-K1 cells assessed as NECA-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type A2A receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Antagonist activity at human wild-type A3 receptor expressed in CHO-K1 cells assessed as IB MECA-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type A3 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
| ChEMBL | Antagonist activity at human wild-type alpha 1A receptor expressed in CHO cells assessed as EP-induced calcium by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type alpha 1A receptor expressed in CHO cells assessed as calcium level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
| ChEMBL | Antagonist activity at human wild-type alpha 2A receptor expressed in CHO-K1 cells assessed as epinephrine-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type alpha 2A receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] | ||||||||
| ChEMBL | Antagonist activity at human wild-type alpha 2C receptor expressed in CHO-K1 cells assessed as epinephrine-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type alpha 2C receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 6.7 | pKd | 199.53 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
| ChEMBL | Displacement of [3H]-CGP 12177 from human beta-1 adrenergic receptor expressed in CHOK1 cells | B | 8.22 | pKd | 6.03 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
| ChEMBL | Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 8.74 | pKd | 1.82 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
| ChEMBL | Displacement of [3H]-CGP12177 from human beta1 ADR expressed in HEK293T cell membranes after 90 mins by scintillation counting | B | 7.93 | pKi | 11.75 | nM | Ki | J Med Chem (2018) 61: 5380-5394 [PMID:29851481] |
| ChEMBL | Inhibition of [3H]dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes. | B | 8.64 | pKi | 2.3 | nM | Ki | J Med Chem (1993) 36: 157-161 [PMID:8093626] |
| ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 8.83 | pKi | 1.47 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Displacement of [3H]CGP12177 from human beta1 adrenoceptor expressed in HEK293T cell membranes | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg Med Chem (2019) 27: 2959-2971 [PMID:31151791] |
| ChEMBL | Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay | F | 6.6 | pIC50 | 251.19 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Tested for Beta-1 adrenergic receptor selectivity in canine cardiac tissue in anesthetized dogs | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (1990) 33: 2883-2891 [PMID:1976812] |
| ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 8.59 | pIC50 | 2.54 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| β1-adrenoceptor/Beta-1 adrenergic receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3440] [GtoPdb: 28] [UniProtKB: P34971] | ||||||||
| ChEMBL | Displacement of [3H]CGP12177 from mouse beta1 adrenoceptor expressed in HEK293T cell membranes | B | 8.62 | pKi | 2.4 | nM | Ki | Bioorg Med Chem (2019) 27: 2959-2971 [PMID:31151791] |
| β1-adrenoceptor/Beta-1 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090] | ||||||||
| ChEMBL | Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer) | F | 5.58 | pKd | 2630.27 | nM | Kd | J Med Chem (1998) 41: 1613-1618 [PMID:9572886] |
| ChEMBL | Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria | F | 8.36 | pKd | 4.37 | nM | Kd | J Med Chem (1987) 30: 1003-1011 [PMID:2884312] |
| ChEMBL | Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria | F | 8.36 | pKd | 4.37 | nM | Kd | J Med Chem (1987) 30: 1003-1011 [PMID:2884312] |
| ChEMBL | Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer) | F | 8.62 | pKd | 2.4 | nM | Kd | J Med Chem (1998) 41: 1613-1618 [PMID:9572886] |
| ChEMBL | Apparent dissociation constant towards beta-1 adrenergic receptor in rat heart membranes using (2-6)x10E-9M of [3AH]-DHA in the presence or absence of 10e-5 M (+/-) propranolol. | B | 9.7 | pKd | 0 | M | KD' | J Med Chem (1987) 30: 722-726 [PMID:3031293] |
| ChEMBL | Displacement of [3H]CGP12177 from beta-1 adrenergic receptor in rat cerebral cortex by liquid scintillation counting | B | 5.01 | pKi | 9700 | nM | Ki | Bioorg Med Chem (2009) 17: 1345-1352 [PMID:19131251] |
| ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor Y356A mutant expressed in CHO cells | F | 6.7 | pKi | 199.53 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
| ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor S190A mutant expressed in CHO cells | F | 7.4 | pKi | 39.81 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
| ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor Y356F mutant expressed in CHO cells | F | 7.5 | pKi | 31.62 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
| ChEMBL | Displacement of [3H]-CGP-12177 from beta1-adrenergic receptor in rat brain cortex after 1 hr by Microbeta scintillation counting method | B | 7.82 | pKi | 15 | nM | Ki | Eur J Med Chem (2018) 147: 102-114 [PMID:29425815] |
| ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor W134A mutant expressed in CHO cells | F | 8 | pKi | 10 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
| ChEMBL | Displacement of [3H]CGP-12177 from beta1 adrenergic receptor in rat brain cerebral cortex after 60 mins by microbeta scintillation counting method | B | 8.15 | pKi | 7 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 5315-5321 [PMID:27692547] |
| ChEMBL | Antagonist activity at rat wild type beta-1 adrenergic receptor expressed in CHO cells | F | 8.5 | pKi | 3.16 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
| ChEMBL | Displacement of [3H]CGP12177 from beta1 adrenoreceptor in Rattus norvegicus (rat) cerebral cortex by liquid scintillation counting | B | 8.52 | pKi | 3 | nM | Ki | Med Chem Res (2008) 17: 507-514 |
| Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73] | ||||||||
| ChEMBL | Inhibition of beta1-adrenergic receptor in guinea pig auricle assessed as reversal of isoproterenol-induced effect | B | 6.6 | pKd | 253.4 | nM | Kd | J Med Chem (1978) 21: 68-72 [PMID:22756] |
| ChEMBL | Competitive antagonist activity at beta-1 adrenergic receptor in guinea pig assessed as inhibition of isoproterenol-induced atrial contractile force | B | 7.85 | pKd | 14.13 | nM | Kd | J Med Chem (1979) 22: 210-214 [PMID:34040] |
| ChEMBL | Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea | F | 7.9 | pKd | 12.59 | nM | Kd | J Med Chem (1987) 30: 1003-1011 [PMID:2884312] |
| ChEMBL | Competitive antagonist activity at beta-1 adrenergic receptor in guinea pig assessed as inhibition of isoproterenol-induced atrial beat rate | B | 8.02 | pKd | 9.55 | nM | Kd | J Med Chem (1979) 22: 210-214 [PMID:34040] |
| ChEMBL | Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria | F | 8.06 | pKd | 8.71 | nM | Kd | J Med Chem (1981) 24: 994-998 [PMID:6120237] |
| ChEMBL | Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB) | F | 8.51 | pKd | 3.09 | nM | Kd | J Med Chem (1984) 27: 857-861 [PMID:6330358] |
| ChEMBL | Beta-1 adrenergic receptor activation measured by isoprenaline-induced positive inotropic effect in guinea pig left atrium | B | 8.6 | pKd | 2.51 | nM | Kd | J Med Chem (1988) 31: 2122-2126 [PMID:2903245] |
| ChEMBL | Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig | F | 8.62 | pKd | 2.4 | nM | Kd | J Med Chem (1980) 23: 620-624 [PMID:6104730] |
| ChEMBL | Beta-1 adrenergic receptor blocking activity in atria of guinea pig. | B | 8.62 | pKd | 2.4 | nM | Kd | J Med Chem (1984) 27: 1291-1294 [PMID:6148422] |
| ChEMBL | In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atria | B | 8.62 | pKd | 2.4 | nM | Kd | J Med Chem (1985) 28: 896-900 [PMID:2861288] |
| ChEMBL | Antagonist activity at beta1 adrenoceptor in guinea pig atrium assessed as inhibition of isoproterenol-induced response after 20 mins | B | 8.7 | pKd | 2 | nM | Kd | J Med Chem (1978) 21: 1081-1084 [PMID:31474] |
| ChEMBL | Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation | B | 8.7 | pKd | 2 | nM | Kd | J Med Chem (1982) 25: 1408-1412 [PMID:6130154] |
| ChEMBL | In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated guinea pig atria | B | 8.76 | pKd | 1.74 | nM | Kd | J Med Chem (1986) 29: 1065-1080 [PMID:2872332] |
| ChEMBL | In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea pig atrial preparations | B | 8.76 | pKd | 1.74 | nM | Kd | J Med Chem (1983) 26: 950-957 [PMID:6134834] |
| ChEMBL | Inhibitory activity against beta-1 adrenergic receptor in guinea pig atria is determined | B | 7.46 | pIC50 | 34.67 | nM | IC50 | J Med Chem (1993) 36: 3077-3086 [PMID:8230093] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes assessed as intrinsic Kd by liquid scintillation counting | B | 6.82 | pKd | 150 | nM | Kd | J Med Chem (2016) 59: 5780-5789 [PMID:27239696] |
| ChEMBL | Binding affinity to human adrenergic beta2 receptor | B | 9.1 | pKd | 0.79 | nM | Kd | Eur J Med Chem (2009) 44: 2840-2846 [PMID:19168263] |
| ChEMBL | Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cells | B | 9.22 | pKd | 0.6 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
| ChEMBL | Antagonist activity at human beta-2 adrenergic receptor expressed in salbutamol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 9.62 | pKd | 0.24 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
| ChEMBL | Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes by liquid scintillation counting | B | 10 | pKd | 0.1 | nM | Kd | J Med Chem (2016) 59: 5780-5789 [PMID:27239696] |
| ChEMBL | Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis | B | 8.43 | pKi | 3.69 | nM | Ki | Bioorg Med Chem (2014) 22: 234-246 [PMID:24326276] |
| ChEMBL | Displacement of [3H]-CGP12177 from human beta2 ADR expressed in HEK293T cell membrane after 90 mins by scintillation counting | B | 8.76 | pKi | 1.74 | nM | Ki | J Med Chem (2018) 61: 5380-5394 [PMID:29851481] |
| ChEMBL | DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) | B | 9.12 | pKi | 0.77 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Displacement of [3H]-CGP-12177 from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis | B | 9.34 | pKi | 0.46 | nM | Ki | Bioorg Med Chem (2014) 22: 234-246 [PMID:24326276] |
| ChEMBL | Displacement of [3H]CGP12177 from human beta2 adrenoceptor expressed in CHO cell membranes | B | 9.49 | pKi | 0.32 | nM | Ki | Bioorg Med Chem (2019) 27: 2959-2971 [PMID:31151791] |
| GtoPdb | - | - | 9.5 | pKi | - | - | - |
Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020]; Mol Pharmacol (1999) 56: 875-85 [PMID:10531390]; Br J Pharmacol (2005) 144: 317-22 [PMID:15655528]; Mol Pharmacol (2003) 64: 679-88 [PMID:12920204] |
| ChEMBL | Antagonist activity at human beta2 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay | F | 7.3 | pIC50 | 50.12 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) | B | 8.95 | pIC50 | 1.12 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Antagonist activity at ADRB2 endogenously expressed in HEK293 cells transfected with cAMP FRET biosensor assessed as inhibition of cimaterol-induced response pre-incubated for 45 mins under dark conditions by FRET assay | F | 9.26 | pIC50 | 0.55 | nM | IC50 | J Med Chem (2020) 63: 8458-8470 [PMID:32686936] |
| ChEMBL | Antagonist activity at ADRB2 endogenously expressed in HEK293 cells transfected with cAMP FRET biosensor assessed as inhibition of cimaterol-induced response pre-incubated for 45 mins under constant violet light conditions by FRET assay | F | 9.32 | pIC50 | 0.48 | nM | IC50 | J Med Chem (2020) 63: 8458-8470 [PMID:32686936] |
| Beta-2 adrenergic receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2289] [UniProtKB: P54833] | ||||||||
| ChEMBL | Compound was evaluated for competitive antagonism of beta-2 adrenergic receptor in rat uterus measured as pA2 (-log KB) | F | 8.75 | pKd | 1.78 | nM | Kd | J Med Chem (1984) 27: 857-861 [PMID:6330358] |
| ChEMBL | Tested for Beta-2 adrenergic receptor selectivity in canine lung tissue in anesthetized dogs | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1990) 33: 2883-2891 [PMID:1976812] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3754] [GtoPdb: 29] [UniProtKB: P10608] | ||||||||
| ChEMBL | Apparent dissociation constant towards beta-2 adrenergic receptor in rat lung membranes using (2-6)x10E-9M of [3AH]-DHA in the presence or absence of 10e-5 M (+/-) propranolol. | B | 9.4 | pKd | 0 | M | KD' | J Med Chem (1987) 30: 722-726 [PMID:3031293] |
| Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
| ChEMBL | Inhibition of beta2-adrenergic receptor in guinea pig tracheal chain assessed as reversal of isoproterenol-induced effect after 15 mins | B | 6.62 | pKd | 240.88 | nM | Kd | J Med Chem (1978) 21: 68-72 [PMID:22756] |
| ChEMBL | Antagonist activity of compound against Beta-2 adrenergic receptor in isolated guinea pig trachea | F | 7.36 | pKd | 43.65 | nM | Kd | J Med Chem (1981) 24: 994-998 [PMID:6120237] |
| ChEMBL | Competitive antagonist activity at beta-2 adrenergic receptor in guinea pig assessed as inhibition of isoproterenol-induced tracheal relaxation | B | 7.83 | pKd | 14.79 | nM | Kd | J Med Chem (1979) 22: 210-214 [PMID:34040] |
| ChEMBL | Beta-2 adrenergic receptor blocking activity in trachea of guinea pig. | B | 8.47 | pKd | 3.39 | nM | Kd | J Med Chem (1984) 27: 1291-1294 [PMID:6148422] |
| ChEMBL | The apparent pA2 value was measured for beta-2 adrenergic blocking activity on the trachea of guinea pig | F | 8.47 | pKd | 3.39 | nM | Kd | J Med Chem (1980) 23: 620-624 [PMID:6104730] |
| ChEMBL | Antagonism of isoprenaline-induced relaxation of guinea pig tracheal chains, contracted with carbachol | F | 8.47 | pKd | 3.39 | nM | Kd | J Med Chem (1988) 31: 2122-2126 [PMID:2903245] |
| ChEMBL | In vitro inhibitory activity against beta-2 adrenergic receptor determined as pA2 in guinea pig trachea | B | 8.47 | pKd | 3.39 | nM | Kd | J Med Chem (1985) 28: 896-900 [PMID:2861288] |
| ChEMBL | In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tracheal chains contracted with PGF2-alpha | B | 8.52 | pKd | 3.02 | nM | Kd | J Med Chem (1983) 26: 950-957 [PMID:6134834] |
| ChEMBL | Antagonist activity at adrenergic beta2 receptor in isolated guinea pig trachea assessed as inhibition of isoprenaline-induced bronchodilation incubated for 20 mins | F | 8.57 | pKd | 2.69 | nM | Kd | Bioorg Med Chem (2018) 26: 3773-3784 [PMID:29706529] |
| ChEMBL | Antagonist activity at beta2 adrenoceptor in guinea pig trachea assessed as inhibition of isoproterenol-induced response after 20 mins | B | 8.86 | pKd | 1.38 | nM | Kd | J Med Chem (1978) 21: 1081-1084 [PMID:31474] |
| ChEMBL | Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparation | B | 8.9 | pKd | 1.26 | nM | Kd | J Med Chem (1982) 25: 1408-1412 [PMID:6130154] |
| ChEMBL | In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha contracted guinea pig trachea | B | 9.01 | pKd | 0.98 | nM | Kd | J Med Chem (1986) 29: 1065-1080 [PMID:2872332] |
| ChEMBL | Inhibitory activity against beta-2 adrenergic receptor in guinea pig tracheal strip is determined | B | 7.54 | pIC50 | 28.84 | nM | IC50 | J Med Chem (1993) 36: 3077-3086 [PMID:8230093] |
| β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
| ChEMBL | Displacement of [3H]-CGP 12177 from human beta-3 adrenergic receptor expressed in CHOK1 cells | B | 6.67 | pKd | 213.8 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
| ChEMBL | Antagonist activity at human beta-3 adrenergic receptor expressed in fenoterol-stimulated CHOK1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 6.79 | pKd | 162.18 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
| ChEMBL | DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) | B | 7 | pKi | 99 | nM | Ki | DrugMatrix in vitro pharmacology data |
| GtoPdb | - | - | 7.2 | pKi | - | - | - |
Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020]; Br J Pharmacol (2005) 144: 317-22 [PMID:15655528]; Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619] |
| ChEMBL | DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) | B | 6.88 | pIC50 | 132 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| β3-adrenoceptor in Mouse [GtoPdb: 30] [UniProtKB: P25962] | ||||||||
| GtoPdb | - | - | 6.6 | pKi | - | - | - | Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619] |
| β3-adrenoceptor in Rat [GtoPdb: 30] [UniProtKB: P26255] | ||||||||
| GtoPdb | - | - | 6.4 | pKi | - | - | - | Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619] |
| Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells | F | 5.26 | pIC50 | 5500 | nM | IC50 | J Pharmacol Exp Ther (1999) 291: 1204-1209 [PMID:10565843] |
| CCK1 receptor/Cholecystokinin A receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238] | ||||||||
| ChEMBL | Antagonist activity at human wild-type CCKA receptor expressed in CHO-K1 cells assessed as CCK8-induced calcium by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type CCKA receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.4 | pIC50 | 4000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.7 | pIC50 | 2000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Antagonist activity at human wild-type opioid-delta 1 receptor expressed in CHO-K1 cells assessed as DPDPE-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type opioid-delta 1 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
| ChEMBL | Antagonist activity at human wild-type D1 receptor expressed in CHO cells assessed as dopamine-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type D1 receptor expressed in CHO cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Antagonist activity at human wild-type D2 receptor expressed in CHO-K1 cells assessed as dopamine-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type D2 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
| ChEMBL | Inhibitory constant against binding of [125I]- IBZM to D2 receptor in rat striatal membrane | B | 4.89 | pKi | 12902 | nM | Ki | J Med Chem (1988) 31: 1039-1043 [PMID:2966245] |
| ChEMBL | Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligand | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1990) 33: 171-178 [PMID:2136916] |
| D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
| ChEMBL | Tested for binding affinity against dopamine receptor D3 expressed in Sf9 cells. | B | 5.3 | pKi | >5000 | nM | Ki | J Med Chem (1993) 36: 1499-1500 [PMID:8098771] |
| ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101] | ||||||||
| ChEMBL | Antagonist activity at human wild-type ETA receptor expressed in CHO-K1 cells assessed as endothelin-1-induced calcium by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type ETA receptor expressed in CHO-K1 cells assessed as calcium level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of hERG K channel | F | 5.55 | pIC50 | 2828 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Antagonist activity at human wild-type opioid-kappa 1 receptor expressed in CHO-K1 cells assessed as U50488-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type opioid-kappa 1 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Antagonist activity at human wild-type opioid-mu receptor expressed in CHO-K1 cells assessed as DAMGO-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type opioid-mu receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
| ChEMBL | Antagonist activity at human wild-type M1 receptor expressed in CHO-K1 cells assessed as acetylcholine-induced calcium by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type M1 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| ChEMBL | Antagonist activity at human wild-type M2 receptor expressed in CHO-K1 cells assessed as acetylcholine-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type M2 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
| ChEMBL | Antagonist activity at human wild-type M3 receptor expressed in CHO-K1 cells assessed as acetylcholine-induced calcium by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type M3 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| TLX/Nuclear receptor subfamily 2 group E member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1961788] [GtoPdb: 615] [UniProtKB: Q9Y466] | ||||||||
| ChEMBL | Binding affinity to TLX LBD expressed in His6-tagged Escherichia coli Rosetta assessed as binding constant measured after 300 sec at 200 mM by isothermal titration calorimetry | B | 6.3 | pKd | 500 | nM | Kd | J Med Chem (2021) 64: 8727-8738 [PMID:34115934] |
| ChEMBL | Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activity incubated for 14 hrs by Dual-glo luciferase | B | 4.43 | pEC50 | 37000 | nM | EC50 | J Med Chem (2021) 64: 8727-8738 [PMID:34115934] |
| ChEMBL | Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured after 14 hrs by luciferase reporter gene assay relative to control | B | 4.49 | pEC50 | 32000 | nM | EC50 | J Med Chem (2021) 64: 8727-8738 [PMID:34115934] |
| ChEMBL | Agonist activity at full length TLX activating element expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as decrease in reporter activity at 100 uM by luciferase reporter gene assay relative to control | B | 4.49 | pEC50 | 32000 | nM | EC50 | J Med Chem (2021) 64: 8727-8738 [PMID:34115934] |
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model | B | 4.32 | pKi | 48000 | nM | Ki | J Med Chem (2002) 45: 5671-5686 [PMID:12477351] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs by lactate dehydrogenase assay | F | 4.42 | pIC50 | 37680 | nM | IC50 | Bioorg Med Chem (2012) 20: 893-902 [PMID:22196513] |
| Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by lactate dehydrogenase assay | F | 4.99 | pIC50 | 10190 | nM | IC50 | Bioorg Med Chem (2012) 20: 893-902 [PMID:22196513] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
| ChEMBL | Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) | B | 6.86 | pKi | 139 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [125I]trans-8-OH-PIPAT in membrane homogenates of hippocampal tissue of rat brain | B | 6.95 | pKi | 113 | nM | Ki | J Med Chem (1993) 36: 3161-3165 [PMID:8230102] |
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand. | B | 7.05 | pKi | 90 | nM | Ki | J Med Chem (1989) 32: 859-863 [PMID:2539480] |
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) | B | 6.61 | pIC50 | 243 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
| ChEMBL | Agonist activity to the human recombinant 5-hydroxytryptamine 1B receptor | F | 5 | pKi | >10000 | nM | Ki | J Med Chem (1997) 40: 4415-4419 [PMID:9435911] |
| ChEMBL | Antagonist activity at human 5-HT1B receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human 5-HT1B receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| 5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] | ||||||||
| ChEMBL | Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand. | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (1989) 32: 859-863 [PMID:2539480] |
| 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) | B | 6.38 | pKi | 419 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Antagonist activity at human 5-HT2A receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) | B | 5.83 | pIC50 | 1466 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 6.66 | pKi | 218 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Antagonist activity at human 5-HT2B receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 6.47 | pIC50 | 342 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Agonist activity at human 5-HT2B receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) | B | 5.92 | pKi | 1202 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Antagonist activity at human 5-HT2C receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) | B | 5.64 | pIC50 | 2294 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Agonist activity at human 5-HT2C receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 5.85 | pKi | 1423 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | Antagonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as seretonin-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 5.51 | pIC50 | 3065 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Agonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as cAMP by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
| ChEMBL | Antagonist activity at human wild-type 5-HT7 receptor expressed in HEK cells assessed as seretonin-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type 5-HT7 receptor expressed in HEK cells assessed as cAMP by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
| ChEMBL | DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) | B | 6.69 | pKi | 202 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) | B | 6.42 | pIC50 | 380 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
| ChEMBL | DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) | B | 5.92 | pKi | 1206 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) | B | 5.54 | pIC50 | 2870 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
| ChEMBL | Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA | F | 5.68 | pIC50 | 2100 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
| Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
| ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 4.2 | pIC50 | 63200 | nM | IC50 | J Med Chem (2008) 51: 5932-5942 [PMID:18788725] |
| AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| ChEMBL | Antagonist activity at human wild-type AGTR1 receptor expressed in CHO-K1 cells assessed as angiotensin-2-induced calcium by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type AGTR1 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
| ChEMBL | Antagonist activity at human wild-type AVPR1A receptor expressed in CHO-K1 cells assessed as vassopressin-induced calcium by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| ChEMBL | Agonist activity at human wild-type AVPR1A receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
| Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] | ||||||||
| ChEMBL | Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes | F | 4.74 | pIC50 | 18000 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
| ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes | F | 4.74 | pIC50 | 18000 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] | ||||||||
| ChEMBL | Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit | F | 4.68 | pIC50 | 21000 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
