JMS-053 [Ligand Id: 12480] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4445621 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibition of human PTP1B assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mins in presence of DTT by Fluorescence based method | B | 4.1 | pIC50 | >80000 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2008-2015 [PMID:31307888] |
| protein tyrosine phosphatase 4A3/Protein-tyrosine phosphatase 4A3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4162] [GtoPdb: 3224] [UniProtKB: O75365] | ||||||||
| ChEMBL | Inhibition of recombinant human PTP4A3 | B | 7.08 | pIC50 | 84 | nM | IC50 | Bioorg Med Chem Lett (2021) 46: 128167-128167 [PMID:34089839] |
| ChEMBL | Inhibition of recombinant human His-6-tagged PTP4A3 expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mins in presence of DTT by Fluorescence based method | B | 7.46 | pIC50 | 35 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2008-2015 [PMID:31307888] |
| ChEMBL | Inhibition of recombinant human His6-tagged PRL-3 expressed in Escherichia coli using DiFMUP as substrate incubated for 30 mins by fluorescence based assay | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2021) 41: 127981-127981 [PMID:33766767] |
| GtoPdb | Inhibition of recombinant human His6-tagged PRL-3, using DiFMUP as substrate in a fluorescence based assay. | - | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (2021) 41: 127981 [PMID:33766767] |
| Protein tyrosine phosphatase type IVA 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075169] [UniProtKB: Q93096] | ||||||||
| ChEMBL | Inhibition of PTP4A1 (unknown origin) expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mins in presence of DTT by Fluorescence based method | B | 7.3 | pIC50 | 50 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2008-2015 [PMID:31307888] |
| Protein tyrosine phosphatase type IVA 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075105] [UniProtKB: Q12974] | ||||||||
| ChEMBL | Inhibition of PTP4A2 (unknown origin) expressed in Escherichia coli assessed as reduction in hydrolysis using DIFMUP as substrate incubated for 30 mins in presence of DTT by Fluorescence based method | B | 7.28 | pIC50 | 52 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 2008-2015 [PMID:31307888] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
