[3H]eprosartan [Ligand Id: 3940] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL813 (Eprosartan, SK-108566, SK&F 108566, SK&F-108566, Teveten) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351] | ||||||||
| ChEMBL | In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes. | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1991) 34: 1514-1517 [PMID:2016730] |
| AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
| ChEMBL | Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA) | B | 8.14 | pIC50 | 7.3 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 23-28 |
| ChEMBL | Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA) | B | 8.7 | pIC50 | 2 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 23-28 |
| AT1 receptor in Rat [GtoPdb: 34] [UniProtKB: P29089, P25095] | ||||||||
| GtoPdb | - | - | 9.1 | pKd | 0.83 | nM | Kd | J Recept Res (1993) 13: 849-61 [PMID:8463997] |
| AT1 receptor/Type-1B angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089] | ||||||||
| GtoPdb | - | - | 9.1 | pKd | 0.83 | nM | Kd | J Recept Res (1993) 13: 849-61 [PMID:8463997] |
| ChEMBL | Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50 | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 23-28 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
