[3H]eprosartan [Ligand Id: 3940] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL813 (SK&F-108566, SK-108566, Eprosartan, Teveten, SK&F 108566)
  • AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351]
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  • AT1 receptor/Type-1 angiotensin II receptor in Human [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
  • AT1 receptor in Rat [GtoPdb: 34] [UniProtKB: P29089P25095]
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  • AT1 receptor/Type-1B angiotensin II receptor in Rat [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351]
ChEMBL In vitro inhibition of [125I]AII specific binding towards Angiotensin II receptor in rat mesenteric membranes. B 9 pIC50 1 nM IC50 J. Med. Chem. (1991) 34: 1514-1517 [PMID:2016730]
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
ChEMBL Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA) B 8.14 pIC50 7.3 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 23-28
ChEMBL Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA) B 8.7 pIC50 2 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 23-28
AT1 receptor in Rat [GtoPdb: 34] [UniProtKB: P29089P25095]
GtoPdb - - 9.1 pKd 0.83 nM Kd J Recept Res (1993) 13: 849-61 [PMID:8463997]
AT1 receptor/Type-1B angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089]
GtoPdb - - 9.1 pKd 0.83 nM Kd J Recept Res (1993) 13: 849-61 [PMID:8463997]
ChEMBL Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50 B 9 pIC50 1 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 23-28

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]