ChEMBL ligand: CHEMBL660 (Amantadine, Amantidine, NSC-341865, Symadine, Symmetrel, TCMDC-125869)
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5] There should be some charts here, you may need to enable JavaScript!
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A in Human [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: Q05586, Q12879, Q13224, Q14957, O15399, O60391, Q8TCU5] GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] There should be some charts here, you may need to enable JavaScript!
GluN1/GluN2A/Glutamate NMDA receptor; GRIN1/GRIN2A in Human [ChEMBL: CHEMBL1907604] [GtoPdb: 455, 456] [UniProtKB: Q05586, Q12879] There should be some charts here, you may need to enable JavaScript!
Influenza virus A matrix protein M2 in Influenza A virus (A/Udorn/307/1972(H3N2)) [ChEMBL: CHEMBL2052] [UniProtKB: P0DOF8] There should be some charts here, you may need to enable JavaScript!
Matrix protein 2 in Influenza A virus [ChEMBL: CHEMBL1932894] [UniProtKB: P06821] There should be some charts here, you may need to enable JavaScript!
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 2/Solute carrier family 22 member 2 in Human [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5]
ChEMBL	The compound was tested for its ability to block PCP N-methyl-D-aspartate glutamate receptor at the PCP (phencyclidine) binding site in postmortem human frontal cortex.	B	4.98	pKi	10500	nM	Ki	J. Med. Chem. (1998) 41: 393-400 [PMID:9464369]
GtoPdb	Measured vs. exogenously expressed zeta1/epsilon3 (GRIN1/GRIN2C) subunits, at pH 6.9	-	4.65	pIC50	22500	nM	IC50	J Physiol (Lond.) (2007) 581: 107-28 [PMID:17303642]
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A in Human [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: Q05586, Q12879, Q13224, Q14957, O15399, O60391, Q8TCU5]
GtoPdb	Measured vs. exogenously expressed zeta1/epsilon3 (GRIN1/GRIN2C) subunits, at pH 6.9	-	4.65	pIC50	22500	nM	IC50	J Physiol (Lond.) (2007) 581: 107-28 [PMID:17303642]
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7]
ChEMBL	Antagonist activity against NMDA receptor in rat cerebellar granule neurons assessed as inhibition of NMDA -induced increase in intracellular calcium level by Fura-2 AM dye based fluorimetry	F	4.04	pIC50	92000	nM	IC50	Bioorg. Med. Chem. (2009) 17: 3198-3206 [PMID:19251424]
ChEMBL	Antagonist activity at NMDA receptor in cerebellar granule neurons assessed as inhibition of NMDA-induced increase in intracellular calcium concentration by fluorometric assay	F	4.04	pIC50	92000	nM	IC50	Bioorg. Med. Chem. (2008) 16: 9925-9936 [PMID:18954995]
ChEMBL	Antagonist activity at NMDA receptor in rat cerebellar granule neurons assessed as inhibition of NMDA-induced increase in intracellular calcium level by fluorometric assay	F	4.04	pIC50	92000	nM	IC50	Bioorg. Med. Chem. (2010) 18: 46-57 [PMID:19954985]
ChEMBL	Antagonist activity at NMDA receptor in Wistar rat cerebellar granule neurons assessed as inhibition of NMDA-induced intracellular calcium by Fura-2 fluorescence assay	B	4.04	pIC50	92000	nM	IC50	Bioorg. Med. Chem. Lett. (2014) 24: 3333-3336 [PMID:24974339]
GluN1/GluN2A/Glutamate NMDA receptor; GRIN1/GRIN2A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907604] [GtoPdb: 455, 456] [UniProtKB: Q05586, Q12879]
ChEMBL	Displacement of [3H]-(+)-MK-801 from phencyclidine binding site of NMDA receptor in human frontal cortex after 22 hrs by scintillation counting analysis	B	5	pKi	10000	nM	Ki	Bioorg. Med. Chem. (2015) 23: 4277-4285 [PMID:26145819]
Influenza virus A matrix protein M2 in Influenza A virus (A/Udorn/307/1972(H3N2)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2052] [UniProtKB: P0DOF8]
ChEMBL	Binding affinity to Influenza A virus M2 transmembrane domain by analytical ultracentrifugation method	B	4.92	pKd	12000	nM	Kd	J Med Chem (2017) 60: 1716-1733 [PMID:28107633]
ChEMBL	Binding affinity to Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes at pH 5.5 by two-electrode voltage clamp assay	B	5.05	pKd	9000	nM	Kd	ACS Med Chem Lett (2018) 9: 198-203 [PMID:29541360]
ChEMBL	Binding affinity to Influenza A virus A/Udorn/72 wild-type M2 proton channel by isothermal calorimetric titration	B	5.66	pKd	2170	nM	Kd	ACS Med Chem Lett (2018) 9: 198-203 [PMID:29541360]
ChEMBL	Inhibition of Influenza A virus wild type M2 proton channel infected in Xenopus laevis oocytes after 2 mins by TEVC assay	B	4.79	pIC50	16100	nM	IC50	J. Med. Chem. (2016) 59: 1207-1216 [PMID:26771709]
ChEMBL	Inhibition of wild type Influenza A virus (A/udorn/72(H3N2)) M2 channel expressed in Xenopus oocyte plasma membrane incubated for 2 mins measured over 48 to 72 hrs by two-electrode voltage clamp method	B	4.8	pIC50	16000	nM	IC50	J. Med. Chem. (2014) 57: 5738-5747 [PMID:24941437]
ChEMBL	Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes assessed as blockade of inward currents at pH 5.5 after 2 mins by two-electrode voltage clamp assay	B	4.9	pIC50	12500	nM	IC50	ACS Med Chem Lett (2018) 9: 198-203 [PMID:29541360]
ChEMBL	Inhibition of Influenza A virus A/Udorn/72 wild-type M2 proton channel expressed in Xenopus laevis oocytes assessed as blockade of inward currents at pH 5.5 after 5 mins by two-electrode voltage clamp assay	B	5.33	pIC50	4700	nM	IC50	ACS Med Chem Lett (2018) 9: 198-203 [PMID:29541360]
ChEMBL	Inhibition of wild type Influenza A virus (A/chicken/Hubei/327/2004(H5N1)) M2 channel expressed in yeast after 46 to 48 hrs by yeast growth restoration assay	B	6.18	pEC50	660	nM	EC50	Eur J Med Chem (2018) 159: 206-216 [PMID:30292897]
ChEMBL	Inhibition of wild type Influenza A virus (A/chicken/Hubei/327/2004(H5N1)) M2 expressed in yeast cells after 46 to 48 hrs	B	6.18	pEC50	660	nM	EC50	MedChemComm (2019) 10: 89-100 [PMID:31559005]
Matrix protein 2 in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1932894] [UniProtKB: P06821]
ChEMBL	Binding affinity to Influenza A Weybridge(H7N7) virus Matrix protein 2 by spectrophotometry	B	6.49	pKd	320	nM	Kd	Bioorg. Med. Chem. Lett. (2010) 20: 4182-4187 [PMID:20570509]
ChEMBL	Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assay	B	4.8	pIC50	16000	nM	IC50	J. Med. Chem. (2011) 54: 2646-2657 [PMID:21466220]
Multidrug and toxin extrusion/Multidrug and toxin extrusion protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743126] [GtoPdb: 1216] [UniProtKB: Q96FL8]
ChEMBL	Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay	B	4.42	pIC50	37800	nM	IC50	J. Med. Chem. (2013) 56: 781-795 [PMID:23241029]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	DNDI: Malaria in Vitro, 72 hour	F	5.25	pIC50	5670	nM	IC50	Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligand	B	7.69	pKi	20.25	nM	Ki	Bioorg. Med. Chem. Lett. (1996) 6: 595-600
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
ChEMBL	TP_TRANSPORTER: inhibition pramipexole uptake in rOCT1-injected oocytes	F	4.12	pIC50	76300	nM	IC50	Drug Metab. Dispos. (2005) 33: 495-499 [PMID:15640376]
Organic cation transporter 2/Solute carrier family 22 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743122] [GtoPdb: 1020] [UniProtKB: O15244]
ChEMBL	TP_TRANSPORTER: inhibition of Dopamine uptake (Dopamine: 200 uM) in Xenopus laevis oocytes	F	4.64	pIC50	23000	nM	IC50	Mol. Pharmacol. (1998) 54: 342-352 [PMID:9687576]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]