compound 25 [PMID: 18068976] [Ligand Id: 8568] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL442432 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5028] [GtoPdb: 1658] [UniProtKB: O14672] | ||||||||
| ChEMBL | Inhibition of ADAM10 | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 560-564 [PMID:18068976] |
| GtoPdb | - | - | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 560-4 [PMID:18068976] |
| ChEMBL | Inhibition of HER2 sheddase in human BT474 cells | B | 8.21 | pIC50 | 6.2 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 560-564 [PMID:18068976] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of MMP1 | B | 5.3 | pIC50 | 4999 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 560-564 [PMID:18068976] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of MMP2 | B | 6.27 | pIC50 | 537 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 560-564 [PMID:18068976] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
