Synonyms: MORAb-009
Compound class:
Antibody
Comment: Amatuximab is a chimeric monoclonal antibody to mesothelin (MSLN; Q13421), a cell surface glycoprotein highly expressed in malignant pleural mesothelioma, all pancreatic adenocarcinoma, the majority of ovarian adenocarcinoma, as well as in non-small cell lung and colorectal cancers[5].
The crystal structure of the Fab fragment of amatuximab in complex with a mesothelin fragment (amino acids 7-64) has been deposited in Protein Data Bank with accession 4F33 [4]. |
Classification ![]() |
|
Compound class | Antibody |
International Nonproprietary Names ![]() |
|
INN number | INN |
9343 | amatuximab |
Synonyms ![]() |
MORAb-009 |
Database Links ![]() |
|
Specialist databases | |
IMGT/mAb-DB | 64 |
Other databases | |
GtoPdb PubChem SID | 223366083 |
Search PubMed clinical trials | amatuximab |
Search PubMed titles | amatuximab |
Search PubMed titles/abstracts | amatuximab |
Wikipedia | Amatuximab |