amatuximab

Ligand id: 7750

Name: amatuximab

No information available.
Summary of Clinical Use
Amatuximab is being investigated as a treatment for mesothelin over-expressing cancers [1]. Click here to link to ClinicalTrials.gov's list of amatuximab registered trials. Results from a Phase II trial assessing amatuximab in combination with pemetrexed and cisplatin are reported in [3].
Mechanism Of Action and Pharmacodynamic Effects
Amatuximab is internalised following mesothelin binding and causes antibody-dependent cellular cytotoxicity [2].