cyclacillin   Click here for help

GtoPdb Ligand ID: 4817

Synonyms: ciclacillin | Cyclapen® | Vastcillin® | Wy-4508
Approved drug
cyclacillin is an approved drug
Compound class: Synthetic organic
Comment: This drug is an aminopenicillin belonging to the β-lactam class of antibacterial compounds.

cyclacillin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 138.03
Molecular weight 341.14
XLogP -1.73
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OC(=O)C1N2C(=O)C(C2SC1(C)C)NC(=O)C1(N)CCCCC1
Isomeric SMILES OC(=O)[C@@H]1N2C(=O)[C@H]([C@H]2SC1(C)C)NC(=O)C1(N)CCCCC1
InChI InChI=1S/C15H23N3O4S/c1-14(2)9(12(20)21)18-10(19)8(11(18)23-14)17-13(22)15(16)6-4-3-5-7-15/h8-9,11H,3-7,16H2,1-2H3,(H,17,22)(H,20,21)/t8-,9+,11-/m1/s1
InChI Key HGBLNBBNRORJKI-WCABBAIRSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes
Approved drug? Yes.
IUPAC Name Click here for help
(2S,5R,6R)-6-(1-aminocyclohexaneamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
2764 ciclacillin
Synonyms Click here for help
ciclacillin | Cyclapen® | Vastcillin® | Wy-4508
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Cyclacillin
Other databases
CAS Registry No. 3485-14-1
ChEMBL Ligand CHEMBL1200356
DrugBank Ligand DB01000
DrugCentral Ligand 632
GtoPdb PubChem SID 178101519
PubChem CID 19003
Search Google for chemical match using the InChIKey HGBLNBBNRORJKI-WCABBAIRSA-N
Search Google for chemicals with the same backbone HGBLNBBNRORJKI
Search PubMed clinical trials ciclacillin
Search PubMed titles ciclacillin
Search PubMed titles/abstracts ciclacillin
UniChem Compound Search for chemical match using the InChIKey HGBLNBBNRORJKI-WCABBAIRSA-N
UniChem Connectivity Search for chemical match using the InChIKey HGBLNBBNRORJKI-WCABBAIRSA-N
Wikipedia Cyclacillin

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MedChemExpress
Cyclacillin (links to external site)
Cat. No. HY-16158