epigallocatechin [Ligand Id: 12461] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL47386 ((-)-Epigallocatechin, Epigallocatechin)
  • aldo-keto reductase family 1 member B/Aldose reductase in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
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  • BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415]
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  • CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
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  • Enoyl-[acyl-carrier-protein] reductase in Escherichia coli [ChEMBL: CHEMBL1857] [UniProtKB: P0AEK4]
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  • Enoyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
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  • xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
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  • TAS2R39 in Human [GtoPdb: 675] [UniProtKB: P59534]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL Inhibition of aldose reductase in rat lens homogenate B 4.52 pIC50 >30000 nM IC50 J Nat Prod (2003) 66: 1191-1196 [PMID:14510595]
synuclein alpha/Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840]
ChEMBL Inhibition of human alpha-synuclein filament formation expressed in Escherichia coli BL21(DE3) cells incubated for 72 hrs by thioflavin S based fluorescence assay B 4.97 pIC50 10600 nM IC50 Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415]
ChEMBL Binding affinity to BCL2 B 4 pKi >100000 nM Ki Proc Natl Acad Sci U S A (2007) 104: 19512-19517 [PMID:18040043]
ChEMBL Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assay B 4 pKi >100000 nM Ki Med Chem Res (2010) 19: 817-835
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL Displacement of [3H]-CP55940 from CB1 receptor (unknown origin) B 4.45 pKi 35700 nM Ki J Nat Prod (2019) 82: 636-646 [PMID:30816712]
DNA repair protein RAD52 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2362978] [UniProtKB: P43351]
ChEMBL Inhibition of RAD52 (unknown origin) assessed as effect on RAD52-mediated annealing of complementary oligonucleotides using T-28 ssDNA substrate by FRET assay B 5.31 pIC50 4900 nM IC50 US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (2018)
ChEMBL Inhibition of RAD52 (unknown origin) assessed as effect on RAD52-mediated annealing of complementary oligonucleotides using T-28 ssDNA substrate in presence of replication protein A by FRET assay B 5.32 pIC50 4800 nM IC50 US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (2018)
ChEMBL Inhibition of RAD52 (unknown origin) assessed as reduction in RAD52-ssDNA interaction using Cy3-dT30-Cy5 ssDNA by FRET assay B 5.74 pIC50 1800 nM IC50 US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (2018)
ChEMBL Inhibition of 6His-tagged human RD52 assessed as reduction in RD52 binding to Cy3-dT30-Cy5 ssDNA incubated for 30 mins by FRET assay B 5.74 pIC50 1800 nM IC50 J Med Chem (2020) 63: 14151-14183 [PMID:33135887]
ChEMBL Inhibition of RAD52 (unknown origin) assessed as reduction in RAD52-ssDNA interaction using Cy3-dT30-Cy5 ssDNA in presence of replication protein A by FRET assay B 5.8 pIC50 1600 nM IC50 US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (2018)
Enoyl-[acyl-carrier-protein] reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1857] [UniProtKB: P0AEK4]
ChEMBL Inhibition of Escherichia coli ENR B 4 pIC50 >100000 nM IC50 J Med Chem (2007) 50: 765-775 [PMID:17263522]
Enoyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
ChEMBL Inhibition of Plasmodium falciparum ENR using NADH substrate B 5.43 pKi 3750 nM Ki J Med Chem (2007) 50: 765-775 [PMID:17263522]
ChEMBL Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrate B 5.7 pKi 2000 nM Ki J Med Chem (2007) 50: 765-775 [PMID:17263522]
ChEMBL Inhibition of Plasmodium falciparum ENR in presence of triclosan B 7.76 pKi 17.56 nM Ki J Med Chem (2007) 50: 765-775 [PMID:17263522]
ChEMBL Inhibition of Plasmodium falciparum ENR B 5.15 pIC50 7000 nM IC50 J Med Chem (2007) 50: 765-775 [PMID:17263522]
NAD kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6177] [UniProtKB: O95544]
ChEMBL Inhibition of NADK (unknown origin) by HPLC analysis B 4 pIC50 >100000 nM IC50 ACS Med Chem Lett (2022) 13: 1699-1706 [PMID:36385933]
Ribonuclease HI in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770039] [UniProtKB: P0A7Y4]
ChEMBL Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay B 4.7 pIC50 >20000 nM IC50 Bioorg Med Chem Lett (2011) 21: 2840-2844 [PMID:21489793]
ChEMBL Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay B 4.7 pIC50 >20000 nM IC50 Bioorg Med Chem Lett (2011) 21: 2840-2844 [PMID:21489793]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry B 4 pIC50 >100000 nM IC50 J Nat Prod (1998) 61: 71-76 [PMID:9461655]
TAS2R39 in Human [GtoPdb: 675] [UniProtKB: P59534]
GtoPdb - - 3.4 pEC50 395500 nM EC50 Biochem Biophys Res Commun (2011) 405: 620-5 [PMID:21272567]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]