epigallocatechin [Ligand Id: 12461] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL47386 ((-)-Epigallocatechin, Epigallocatechin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] | ||||||||
| ChEMBL | Inhibition of aldose reductase in rat lens homogenate | B | 4.52 | pIC50 | >30000 | nM | IC50 | J Nat Prod (2003) 66: 1191-1196 [PMID:14510595] |
| Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840] | ||||||||
| ChEMBL | Inhibition of human alpha-synuclein filament formation expressed in Escherichia coli BL21(DE3) cells incubated for 72 hrs by thioflavin S based fluorescence assay | B | 4.97 | pIC50 | 10600 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| BCL2 apoptosis regulator/Apoptosis regulator Bcl-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4860] [GtoPdb: 2844] [UniProtKB: P10415] | ||||||||
| ChEMBL | Binding affinity to BCL2 | B | 4 | pKi | >100000 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 19512-19517 [PMID:18040043] |
| ChEMBL | Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assay | B | 4 | pKi | >100000 | nM | Ki | Med Chem Res (2010) 19: 817-835 |
| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Displacement of [3H]-CP55940 from CB1 receptor (unknown origin) | B | 4.45 | pKi | 35700 | nM | Ki | J Nat Prod (2019) 82: 636-646 [PMID:30816712] |
| DNA repair protein RAD52 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2362978] [UniProtKB: P43351] | ||||||||
| ChEMBL | Inhibition of RAD52 (unknown origin) assessed as effect on RAD52-mediated annealing of complementary oligonucleotides using T-28 ssDNA substrate by FRET assay | B | 5.31 | pIC50 | 4900 | nM | IC50 | US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (null) |
| ChEMBL | Inhibition of RAD52 (unknown origin) assessed as effect on RAD52-mediated annealing of complementary oligonucleotides using T-28 ssDNA substrate in presence of replication protein A by FRET assay | B | 5.32 | pIC50 | 4800 | nM | IC50 | US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (null) |
| ChEMBL | Inhibition of RAD52 (unknown origin) assessed as reduction in RAD52-ssDNA interaction using Cy3-dT30-Cy5 ssDNA by FRET assay | B | 5.74 | pIC50 | 1800 | nM | IC50 | US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (null) |
| ChEMBL | Inhibition of 6His-tagged human RD52 assessed as reduction in RD52 binding to Cy3-dT30-Cy5 ssDNA incubated for 30 mins by FRET assay | B | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2020) 63: 14151-14183 [PMID:33135887] |
| ChEMBL | Inhibition of RAD52 (unknown origin) assessed as reduction in RAD52-ssDNA interaction using Cy3-dT30-Cy5 ssDNA in presence of replication protein A by FRET assay | B | 5.8 | pIC50 | 1600 | nM | IC50 | US-20180209956-A1. HTS Assay for Identifying Small Molecule Inhibitors of RAD52 and Uses of Identified Small Molecule Inhibitors for Treatment and Prevention of BRCA-Deficient Malignancies (null) |
| Enoyl-[acyl-carrier-protein] reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1857] [UniProtKB: P0AEK4] | ||||||||
| ChEMBL | Inhibition of Escherichia coli ENR | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2007) 50: 765-775 [PMID:17263522] |
| Enoyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5] | ||||||||
| ChEMBL | Inhibition of Plasmodium falciparum ENR using NADH substrate | B | 5.43 | pKi | 3750 | nM | Ki | J Med Chem (2007) 50: 765-775 [PMID:17263522] |
| ChEMBL | Inhibition of Plasmodium falciparum ENR using crotonyl-CoA substrate | B | 5.7 | pKi | 2000 | nM | Ki | J Med Chem (2007) 50: 765-775 [PMID:17263522] |
| ChEMBL | Inhibition of Plasmodium falciparum ENR in presence of triclosan | B | 7.76 | pKi | 17.56 | nM | Ki | J Med Chem (2007) 50: 765-775 [PMID:17263522] |
| ChEMBL | Inhibition of Plasmodium falciparum ENR | B | 5.15 | pIC50 | 7000 | nM | IC50 | J Med Chem (2007) 50: 765-775 [PMID:17263522] |
| Ribonuclease HI in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770039] [UniProtKB: P0A7Y4] | ||||||||
| ChEMBL | Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2840-2844 [PMID:21489793] |
| ChEMBL | Inhibition of Escherichia coli recombinant ribonuclease H after 30 mins by FRET quenching assay | B | 4.7 | pIC50 | >20000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2840-2844 [PMID:21489793] |
| xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989] | ||||||||
| ChEMBL | Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry | B | 4 | pIC50 | >100000 | nM | IC50 | J Nat Prod (1998) 61: 71-76 [PMID:9461655] |
| TAS2R39 in Human [GtoPdb: 675] [UniProtKB: P59534] | ||||||||
| GtoPdb | - | - | 3.4 | pEC50 | 395500 | nM | EC50 | Biochem Biophys Res Commun (2011) 405: 620-5 [PMID:21272567] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
