taurolithocholic acid-3-sulphate [Ligand Id: 4548] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL408701 (Taurolithocholate, Taurolithocholic acid, Tauroursodeoxycholic acid)
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  • GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
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  • ABCC4/Multidrug resistance-associated protein 4 in Human [ChEMBL: CHEMBL1743128] [GtoPdb: 782] [UniProtKB: O15439]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
EPH receptor A2/Ephrin type-A receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105859] [GtoPdb: 1822] [UniProtKB: Q03145]
ChEMBL Displacement of biotinylated ephrin-A1-Fc from recombinant mouse EphA2 receptor preincubated for 1 hr followed by biotinylated ephrin-A1-Fc addition measured after 4 hrs by ELISA method B 4.14 pIC50 72000 nM IC50 J Med Chem (2017) 60: 787-796 [PMID:28005388]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay F 6 pEC50 1005.4 nM EC50 RSC Med Chem (2021) 12: 394-405 [PMID:34046622]
ChEMBL Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation after 30 mins by TR-FRET assay F 6.07 pEC50 847 nM EC50 J Med Chem (2019) 62: 6824-6830 [PMID:31268316]
ChEMBL Agonist activity at recombinant human TGR5 expressed in CHO cells assessed as increase in cAMP accumulation in presence of 3-isobutyl-1-methylxanthine after 20 mins F 6.48 pEC50 330 nM EC50 J Med Chem (2019) 62: 6824-6830 [PMID:31268316]
ChEMBL Agonist activity at human TGR5 expressed in CHO cells by luciferase assay F 6.54 pEC50 290 nM EC50 J. Med. Chem. (2008) 51: 1831-1841 [PMID:18307294]
ABCC4/Multidrug resistance-associated protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743128] [GtoPdb: 782] [UniProtKB: O15439]
ChEMBL TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicles from MRP4-expressing HEK-293 cells F 4.7 pIC50 20000 nM IC50 Biochem. J. (2003) 371: 361-367 [PMID:12523936]
Vitamin D receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1977] [GtoPdb: 605] [UniProtKB: P11473]
ChEMBL Antagonist activity against VP16 tagged-VDR-LBD (unknown origin) expressed in HEK293T cells assessed as inhibition of 1,25-dihydroxyvitamin D3-induced SRC1 coactivator peptide recruitment after 16 hrs by luciferase reporter gene based two hybrid assay B 4.3 pIC50 >50000 nM IC50 Eur. J. Med. Chem. (2016) 109: 238-246 [PMID:26774929]
ChEMBL Antagonist activity against VDR-LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of VDR agonist LG190178-induced SRC2-3 coactivator peptide recruitment after 30 mins by fluorescence polarization assay B 4.84 pIC50 14500 nM IC50 Eur. J. Med. Chem. (2016) 109: 238-246 [PMID:26774929]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]