compound 35 [PMID: 22902653] [Ligand Id: 8119] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2070619
  • testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
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  • testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569]
GtoPdb - - 4.52 pIC50 >30000 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
ChEMBL Inhibition of TESK1 B 4.52 pIC50 >30000 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53]
GtoPdb - - 4.52 pIC50 >30000 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
ChEMBL Inhibition of TESK2 B 4.52 pIC50 >30000 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667]
GtoPdb - - 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]
ChEMBL Inhibition of LIMK1 B 7.52 pIC50 30 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
ChEMBL Inhibition of human LIMK1 (321 to 647 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid method B 7.52 pIC50 30 nM IC50 Eur J Med Chem (2018) 155: 445-458 [PMID:29908439]
LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671]
ChEMBL Inhibition of LIMK2 B 8.1 pIC50 8 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653]
ChEMBL Inhibition of human LIMK1 (312 to 638 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid method B 8.1 pIC50 8 nM IC50 Eur J Med Chem (2018) 155: 445-458 [PMID:29908439]
GtoPdb - - 8.1 pIC50 8 nM IC50 Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]