compound 35 [PMID: 22902653] [Ligand Id: 8119] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2070619 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569] | ||||||||
| GtoPdb | - | - | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653] |
| ChEMBL | Inhibition of TESK1 | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653] |
| testis associated actin remodelling kinase 2/Dual specificity testis-specific protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069163] [GtoPdb: 2240] [UniProtKB: Q96S53] | ||||||||
| GtoPdb | - | - | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653] |
| ChEMBL | Inhibition of TESK2 | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653] |
| LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667] | ||||||||
| GtoPdb | - | - | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653] |
| ChEMBL | Inhibition of LIMK1 | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653] |
| ChEMBL | Inhibition of human LIMK1 (321 to 647 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid method | B | 7.52 | pIC50 | 30 | nM | IC50 | Eur J Med Chem (2018) 155: 445-458 [PMID:29908439] |
| LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671] | ||||||||
| ChEMBL | Inhibition of LIMK2 | B | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-5998 [PMID:22902653] |
| ChEMBL | Inhibition of human LIMK1 (312 to 638 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid method | B | 8.1 | pIC50 | 8 | nM | IC50 | Eur J Med Chem (2018) 155: 445-458 [PMID:29908439] |
| GtoPdb | - | - | 8.1 | pIC50 | 8 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 5995-8 [PMID:22902653] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
