phosphoenolpyruvic acid [Ligand Id: 4692] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1235228 (Oxo-Phosphonooxy-Acetic Acid)
  • peptidase D/Xaa-Pro dipeptidase in Human [ChEMBL: CHEMBL4185] [GtoPdb: 2389] [UniProtKB: P12955]
  • peptidase D in Pig [GtoPdb: 2389]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
peptidase D/Xaa-Pro dipeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4185] [GtoPdb: 2389] [UniProtKB: P12955]
ChEMBL Inhibitory constant for inhibition of prolidase in the second phase of biphasic inhibition B 3.62 pKi 0.24 mM Ki' Bioorg. Med. Chem. Lett. (1995) 5: 627-630
ChEMBL Inhibitory constant for inhibition of prolidase in the first phase of biphasic inhibition B 6.52 pKi 300 nM Ki Bioorg. Med. Chem. Lett. (1995) 5: 627-630
ChEMBL Inhibition of prolidase from swine kidney at a pH 6 B 8.07 pKi 8.5 nM Ki Bioorg. Med. Chem. Lett. (1995) 5: 627-630
peptidase D in Pig [GtoPdb: 2389]
GtoPdb Biphasic inhibition of purified enzyme from pig kidney. - 9.62 pKi 0.24 nM Ki Bioorg. Med. Chem. Lett. (1995) 5: 627-630

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]