phosphoenolpyruvic acid [Ligand Id: 4692] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1235228 (Oxo-Phosphonooxy-Acetic Acid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| peptidase D/Xaa-Pro dipeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4185] [GtoPdb: 2389] [UniProtKB: P12955] | ||||||||
| ChEMBL | Inhibitory constant for inhibition of prolidase in the second phase of biphasic inhibition | B | 3.62 | pKi | 0.24 | mM | Ki' | Bioorg Med Chem Lett (1995) 5: 627-630 |
| ChEMBL | Inhibitory constant for inhibition of prolidase in the first phase of biphasic inhibition | B | 6.52 | pKi | 300 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 627-630 |
| ChEMBL | Inhibition of prolidase from swine kidney at a pH 6 | B | 8.07 | pKi | 8.5 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 627-630 |
| peptidase D in Pig [GtoPdb: 2389] | ||||||||
| GtoPdb | Biphasic inhibition of purified enzyme from pig kidney. | - | 9.62 | pKi | 0.24 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 627-630 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
