peptidase D | M24: Methionyl aminopeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

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peptidase D

Target not currently curated in GtoImmuPdb

Target id: 2389

Nomenclature: peptidase D

Family: M24: Methionyl aminopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 493 19q13.11 PEPD peptidase D
Mouse - 493 7 B1 Pepd peptidase D
Rat - 492 1q21 Pepd peptidase D
Previous and Unofficial Names
imidodipeptidase | Pep4 | peptidase 4 | prolidase | proline dipeptidase
Database Links
Specialist databases
MEROPS M24.007 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
phosphoenolpyruvic acid Pig Inhibition 9.5 – 9.6 pKi 1
pKi 9.5 – 9.6 (Ki 3x10-10 – 2.4x10-10 M) [1]
Description: Biphasic inhibition of purified enzyme from pig kidney.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Prolidase deficiency
OMIM: 170100
Orphanet: ORPHA742


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1. Mock WA, Liu Y. (1995) Inhibition of prolidase by phosphoenolpyruvate is biphasic. avoidance of endogenous-metabolite inactivation by cooperativity within an enzyme dimer. Bioorg. Med. Chem. Lett., 5 (6): 627-630.

How to cite this page

M24: Methionyl aminopeptidase: peptidase D. Last modified on 22/07/2015. Accessed on 14/08/2020. IUPHAR/BPS Guide to PHARMACOLOGY,