LY-465608 [Ligand Id: 2659] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL25259 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Binding affinity for human peroxisome proliferator activated receptor alpha | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2004) 47: 4118-4127 [PMID:15293980] |
| ChEMBL | Binding affinity towards human peroxidase proliferator activated receptor alpha (hPPARalpha) | B | 6.76 | pIC50 | 174 | nM | IC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| GtoPdb | - | - | 6.8 | pIC50 | - | - | - |
J Med Chem (2001) 44: 2061-4 [PMID:11405642]; J Med Chem (2004) 47: 2422-5 [PMID:15115385] |
| ChEMBL | Agonistic activity for Peroxisome proliferator activated receptor alpha | F | 6.82 | pEC50 | 150 | nM | EC50 | J Med Chem (2003) 46: 1306-1317 [PMID:12672231] |
| ChEMBL | Effective concentration against human peroxisome proliferator activated receptor alpha in Gal4 transactivation assay | B | 6.82 | pEC50 | 150 | nM | EC50 | J Med Chem (2004) 47: 4118-4127 [PMID:15293980] |
| ChEMBL | Binding affinity at human PPAR alpha | B | 6.83 | pEC50 | 149.5 | nM | EC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Binding affinity for human peroxisome proliferator activated receptor gamma | B | 6.26 | pKi | 550 | nM | Ki | J Med Chem (2004) 47: 4118-4127 [PMID:15293980] |
| GtoPdb | - | - | 6.26 | pIC50 | - | - | - | J Med Chem (2001) 44: 2061-4 [PMID:11405642] |
| ChEMBL | Binding affinity at human peroxidase proliferator activated receptor gamma (hPPARgamma) | B | 6.26 | pIC50 | 548 | nM | IC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| ChEMBL | Binding affinity at human PPAR gamma | B | 6.05 | pEC50 | 882 | nM | EC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| ChEMBL | Agonistic activity for human Peroxisome proliferator activated receptor gamma | F | 6.06 | pEC50 | 880 | nM | EC50 | J Med Chem (2003) 46: 1306-1317 [PMID:12672231] |
| ChEMBL | Effective concentration against human peroxisome proliferator activated receptor gamma in Gal4 transactivation assay | B | 6.06 | pEC50 | 880 | nM | EC50 | J Med Chem (2004) 47: 4118-4127 [PMID:15293980] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
