LY-465608 [Ligand Id: 2659] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL25259 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Binding affinity for human peroxisome proliferator activated receptor alpha | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2004) 47: 4118-4127 [PMID:15293980] |
| ChEMBL | Binding affinity towards human peroxidase proliferator activated receptor alpha (hPPARalpha) | B | 6.76 | pIC50 | 174 | nM | IC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| GtoPdb | - | - | 6.8 | pIC50 | - | - | - |
J Med Chem (2001) 44: 2061-4 [PMID:11405642]; J Med Chem (2004) 47: 2422-5 [PMID:15115385] |
| ChEMBL | Agonistic activity for Peroxisome proliferator activated receptor alpha | F | 6.82 | pEC50 | 150 | nM | EC50 | J Med Chem (2003) 46: 1306-1317 [PMID:12672231] |
| ChEMBL | Effective concentration against human peroxisome proliferator activated receptor alpha in Gal4 transactivation assay | B | 6.82 | pEC50 | 150 | nM | EC50 | J Med Chem (2004) 47: 4118-4127 [PMID:15293980] |
| ChEMBL | Binding affinity at human PPAR alpha | B | 6.83 | pEC50 | 149.5 | nM | EC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
| ChEMBL | Binding affinity for human peroxisome proliferator activated receptor gamma | B | 6.26 | pKi | 550 | nM | Ki | J Med Chem (2004) 47: 4118-4127 [PMID:15293980] |
| GtoPdb | - | - | 6.26 | pIC50 | - | - | - | J Med Chem (2001) 44: 2061-4 [PMID:11405642] |
| ChEMBL | Binding affinity at human peroxidase proliferator activated receptor gamma (hPPARgamma) | B | 6.26 | pIC50 | 548 | nM | IC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| ChEMBL | Binding affinity at human PPAR gamma | B | 6.05 | pEC50 | 882 | nM | EC50 | J Med Chem (2001) 44: 2061-2064 [PMID:11405642] |
| ChEMBL | Agonistic activity for human Peroxisome proliferator activated receptor gamma | F | 6.06 | pEC50 | 880 | nM | EC50 | J Med Chem (2003) 46: 1306-1317 [PMID:12672231] |
| ChEMBL | Effective concentration against human peroxisome proliferator activated receptor gamma in Gal4 transactivation assay | B | 6.06 | pEC50 | 880 | nM | EC50 | J Med Chem (2004) 47: 4118-4127 [PMID:15293980] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
