ChEMBL ligand: CHEMBL1229259
coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] There should be some charts here, you may need to enable JavaScript!
ST14 transmembrane serine protease matriptase /Matriptase in Human [ChEMBL: CHEMBL3018] [GtoPdb: 2418] [UniProtKB: Q9Y5Y6] There should be some charts here, you may need to enable JavaScript!
kallikrein B1/Plasma kallikrein in Human [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952] There should be some charts here, you may need to enable JavaScript!
plasminogen/Plasminogen in Human [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] There should be some charts here, you may need to enable JavaScript!
transmembrane serine protease 11D/Transmembrane protease serine 11D in Human [ChEMBL: CHEMBL1795138] [GtoPdb: 2420] [UniProtKB: O60235] There should be some charts here, you may need to enable JavaScript!
transmembrane serine protease 2/Transmembrane protease serine 2 in Human [ChEMBL: CHEMBL1795140] [GtoPdb: 2421] [UniProtKB: O15393] There should be some charts here, you may need to enable JavaScript!
transmembrane serine protease 6/Transmembrane protease serine 6 in Human [ChEMBL: CHEMBL1795139] [GtoPdb: 2422] [UniProtKB: Q8IU80] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL	Inhibition of factor 10a	B	8.62	pKi	2.4	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
ST14 transmembrane serine protease matriptase /Matriptase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3018] [GtoPdb: 2418] [UniProtKB: Q9Y5Y6]
ChEMBL	Inhibition of matriptase	B	7.26	pKi	55	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
kallikrein B1/Plasma kallikrein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952]
ChEMBL	Inhibition of plasma kallikrein	B	8.08	pKi	8.3	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747]
ChEMBL	Inhibition of plasmin	B	7.41	pKi	39	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Inhibition of thrombin	B	8.46	pKi	3.5	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
transmembrane serine protease 11D/Transmembrane protease serine 11D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795138] [GtoPdb: 2420] [UniProtKB: O60235]
GtoPdb	-	-	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4 [PMID:21741839]
ChEMBL	Inhibition of human recombinant airway trypsin-like protease HAT using D-cyclohexylalanine-Pro-Arg-AMC as substrate by fluorescence plate reader analysis	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
transmembrane serine protease 2/Transmembrane protease serine 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795140] [GtoPdb: 2421] [UniProtKB: O15393]
ChEMBL	Inhibition of recombinant catalytic domain of TMPRSS2 expressed in Escherichia coli using Dcyclohexylalanine- Pro-Arg-AMC as substrate by fluorescence plate reader analysis	B	7.7	pKi	20	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]
GtoPdb	-	-	7.7	pKi	20	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4 [PMID:21741839]
transmembrane serine protease 6/Transmembrane protease serine 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795139] [GtoPdb: 2422] [UniProtKB: Q8IU80]
ChEMBL	Inhibition of matriptase 2	B	6.77	pKi	170	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4860-4864 [PMID:21741839]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]