SRI-20864   Click here for help

GtoPdb Ligand ID: 10986

Synonyms: SRI20864
Compound class: Synthetic organic
Comment: SRI-20864 is an experimental antibacterial compound. It acts as an inhibitor of bacterial dihydrofolate reductase (DHFR; an antifolate antibacterial), and was generated in a programme that also included SRI-8858 [1]. These compounds were developed to treat trimethoprim-resistant Mycobacterium avium complex (MAC).
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 121.2
Molecular weight 354.18
XLogP 1.91
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCOc1ccc(c(c1)NCc1cnc2c(c1C)c(N)nc(n2)N)OC
Isomeric SMILES CCOc1ccc(c(c1)NCc1cnc2c(c1C)c(N)nc(n2)N)OC
InChI InChI=1S/C18H22N6O2/c1-4-26-12-5-6-14(25-3)13(7-12)21-8-11-9-22-17-15(10(11)2)16(19)23-18(20)24-17/h5-7,9,21H,4,8H2,1-3H3,(H4,19,20,22,23,24)
InChI Key CRZVJULBIPRHRY-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
6-[(5-ethoxy-2-methoxyanilino)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine
Synonyms Click here for help
SRI20864
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo SRI-20864
Other databases
GtoPdb PubChem SID 405560427
PubChem CID 15954331
Search Google for chemical match using the InChIKey CRZVJULBIPRHRY-UHFFFAOYSA-N
Search Google for chemicals with the same backbone CRZVJULBIPRHRY
UniChem Compound Search for chemical match using the InChIKey CRZVJULBIPRHRY-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey CRZVJULBIPRHRY-UHFFFAOYSA-N