Lysergide [Ligand Id: 17] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL263881 (Lysergic acid diethylamide, Lysergic acid diethylamide tartrate ci, LSD, Lysergide)
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
  • This target only has 1 pki data point
  • 6.85
1 CHEMBL263881_lig_chart_1 Beta-1 adrenergic receptor Human
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
  • This target only has 1 pki data point
  • 6.13
2 CHEMBL263881_lig_chart_2 Beta-2 adrenergic receptor Human
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  • D1 receptor/Dopamine D1 receptor in Mouse [ChEMBL: CHEMBL3071] [GtoPdb: 214] [UniProtKB: Q61616]
  • This target only has 1 pki data point
  • 6.74
3 CHEMBL263881_lig_chart_3 Dopamine D1 receptor Mouse
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  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
  • 6.91
4 CHEMBL263881_lig_chart_4 Dopamine D2 receptor Human
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  • D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
  • This target only has 1 pki data point
  • 7.57
5 CHEMBL263881_lig_chart_5 Dopamine D3 receptor Human
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
  • This target only has 1 pki data point
  • 7.25
6 CHEMBL263881_lig_chart_6 Dopamine D4 receptor Human
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  • D5 receptor/Dopamine D5 receptor in Human [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918]
  • This target only has 1 pki data point
  • 6.47
7 CHEMBL263881_lig_chart_7 Dopamine D5 receptor Human
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  • H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
  • This target only has 1 pki data point
  • 5.81
8 CHEMBL263881_lig_chart_8 Histamine H1 receptor Human
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
  • 8.29
9 CHEMBL263881_lig_chart_9 Serotonin 1a (5-HT1a) receptor HumanRat
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  • 5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
  • This target only has 1 pki data point
  • 8.41
10 CHEMBL263881_lig_chart_10 Serotonin 1d (5-HT1d) receptor Human
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  • 5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
  • This target only has 1 pki data point
  • 7.03
11 CHEMBL263881_lig_chart_11 Serotonin 1e (5-HT1e) receptor Human
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
  • 8.46
12 CHEMBL263881_lig_chart_12 Serotonin 2a (5-HT2a) receptor HumanRat
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  • 5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
  • 5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994]
  • 8.3
13 CHEMBL263881_lig_chart_13 Serotonin 2b (5-HT2b) receptor HumanRat
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  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
  • 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
  • 8.26
14 CHEMBL263881_lig_chart_14 Serotonin 2c (5-HT2c) receptor HumanRat
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  • 5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
  • 8.02
15 CHEMBL263881_lig_chart_15 Serotonin 5a (5-HT5a) receptor Human
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  • 5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
  • 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
  • 8.7
16 CHEMBL263881_lig_chart_16 Serotonin 6 (5-HT6) receptor HumanRat
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  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
  • 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
  • 8.36
17 CHEMBL263881_lig_chart_17 Serotonin 7 (5-HT7) receptor HumanRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Binding affinity towards Beta-1 adrenergic receptor B 6.85 pKi 140 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Binding affinity towards Beta-2 adrenergic receptor B 6.13 pKi 740 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
D1 receptor/Dopamine D1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3071] [GtoPdb: 214] [UniProtKB: Q61616]
ChEMBL Binding affinities towards Dopamine receptor D1 B 6.74 pKi 180 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Binding affinity against human Dopamine receptor D2 in CHO cells using [125I]iodosulpiride B 6.9 pKi 125.89 nM Ki J. Med. Chem. (2003) 46: 5117-5120 [PMID:14613313]
ChEMBL Binding affinity towards Dopamine receptor D2 B 6.92 pKi 120 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL Binding affinity towards Dopamine receptor D3 B 7.57 pKi 27 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL Binding affinity towards Dopamine receptor D4 B 7.25 pKi 56 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
D5 receptor/Dopamine D5 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918]
ChEMBL Binding affinity towards Dopamine receptor D5 B 6.47 pKi 340 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL Binding affinity towards Histamine H1 receptor B 5.81 pKi 1540 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL Binding affinity against 5-hydroxytryptamine 1A human cloned receptors in HEK293 cells using [3H]8-OH-DPAT as radioligand B 8.9 pKi 1.26 nM Ki J. Med. Chem. (2003) 46: 5117-5120 [PMID:14613313]
ChEMBL Tested in vitro for its ability to bind to 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand B 8.96 pKi 1.1 nM Ki J. Med. Chem. (2003) 46: 3526-3535 [PMID:12877591]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand B 8.96 pKi 1.1 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
GtoPdb - - 9 pKi - - - J Med Chem (2002) 45: 4344-9 [PMID:12213075]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Binding affinity was measured against 5-hydroxytryptamine 1A receptor by displacement of [3H]8-OH-DPAT by lysergic acid amides B 8.29 pKi 5.1 nM Ki J. Med. Chem. (1995) 38: 958-966 [PMID:7699712]
ChEMBL Binding affinity of [3H]- -8-OH-DPAT labelled towards Rat Hippocampal 5-hydroxytryptamine 1A receptor using radioligand binding assay B 8.29 pKi 5.1 nM Ki J. Med. Chem. (1996) 39: 2953-2961 [PMID:8709129]
ChEMBL Affinity in displacing [3H]8-OH-DPAT from rat hippocampal 5-HT1A receptor. B 8.3 pKi 5.05 nM Ki J. Med. Chem. (1992) 35: 203-211 [PMID:1732537]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand B 8.41 pKi 3.9 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1E receptor B 7.03 pKi 93 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL Displacement of [3H]INBMeO from human 5HT2A receptor expressed in human A549 cells B 8.4 pKi 4 nM Ki Bioorg. Med. Chem. (2008) 16: 6116-6123 [PMID:18468904]
ChEMBL Displacement of [3H]INBMeO from human 5HT2A receptor expressed in human HEK293 cells B 8.46 pKi 3.5 nM Ki Bioorg. Med. Chem. (2008) 16: 6116-6123 [PMID:18468904]
ChEMBL Binding affinity against 5-hydroxytryptamine 2A receptor human cloned receptors in HEK 293 cells using [3H]ketanserin as radioligand B 8.5 pKi 3.16 nM Ki J. Med. Chem. (2003) 46: 5117-5120 [PMID:14613313]
ChEMBL Displacement of [3H]ketanserin from human 5HT2A receptor expressed in human HEK293 cells B 8.51 pKi 3.1 nM Ki Bioorg. Med. Chem. (2008) 16: 6116-6123 [PMID:18468904]
ChEMBL Displacement of [3H]ketanserin from human 5HT2A receptor expressed in human A549 cells B 8.59 pKi 2.6 nM Ki Bioorg. Med. Chem. (2008) 16: 6116-6123 [PMID:18468904]
GtoPdb - - 9.4 pKi - - - J Biol Chem (1996) 271: 14672-5 [PMID:8663249]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL Binding affinity was measured against 5-hydroxytryptamine 2A receptor by displacement of [3H]- ketanserin by lysergic acid amides B 8.36 pKi 4.4 nM Ki J. Med. Chem. (1995) 38: 958-966 [PMID:7699712]
ChEMBL Binding affinity of [3H]- ketanserin labelled towards Rat cortical 5-hydroxytryptamine 2A receptor using radioligand binding assay B 8.36 pKi 4.4 nM Ki J. Med. Chem. (1996) 39: 2953-2961 [PMID:8709129]
ChEMBL In vitro binding to 5-hydroxytryptamine 2A receptor using [125 I]-DOI B 8.46 pKi 3.5 nM Ki J. Med. Chem. (2003) 46: 3526-3535 [PMID:12877591]
ChEMBL Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]DOI as radioligand B 8.46 pKi 3.5 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
ChEMBL Displacement of [125I]DOI from rat 5HT2A receptor B 8.46 pKi 3.5 nM Ki J. Med. Chem. (2006) 49: 4269-4274 [PMID:16821786]
GtoPdb - - 8.5 pKi - - - J Med Chem (2002) 45: 4344-9 [PMID:12213075]
ChEMBL Tested for its ability to activate phospholipase C by quantification of IP3 at cloned rat 5-hydroxytryptamine 2A receptor B 8.01 pEC50 9.8 nM EC50 J. Med. Chem. (2003) 46: 3526-3535 [PMID:12877591]
ChEMBL Activity at rat 5HT2A receptor assessed as 5-HT-stimulated IP3 accumulation F 8.01 pEC50 9.8 nM EC50 J. Med. Chem. (2006) 49: 4269-4274 [PMID:16821786]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand B 7.52 pKi 30 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
GtoPdb Biased for β-arrestin sihnalling. - 8.43 pKi - - - Science (2013) 340: 615-9 [PMID:23519215]
5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994]
GtoPdb - - 8.3 pKi - - - J Med Chem (2002) 45: 4344-9 [PMID:12213075]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL Binding affinity against 5-hydroxytryptamine 2C receptor human cloned receptors in HEK 293 cells using [3H]mesulergine as radioligand B 8.3 pKi 5.01 nM Ki J. Med. Chem. (2003) 46: 5117-5120 [PMID:14613313]
GtoPdb - - 8.6 pKi - - - Synapse (2000) 35: 144-150 [PMID:10611640]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
ChEMBL In vitro binding to 5-hydroxytryptamine 2C receptor using [125 I]-DOI B 8.26 pKi 5.5 nM Ki J. Med. Chem. (2003) 46: 3526-3535 [PMID:12877591]
ChEMBL Binding affinity towards 5-hydroxytryptamine 2C receptor using [125I]DOI as radioligand B 8.26 pKi 5.5 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
ChEMBL Displacement of [125I]DOI from rat 5HT2C receptor B 8.26 pKi 5.5 nM Ki J. Med. Chem. (2006) 49: 4269-4274 [PMID:16821786]
ChEMBL Compound was tested for binding affinity towards 5-hydroxytryptamine 1C receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]mesulergine as radioligand B 8.42 pKi 3.8 nM Ki J. Med. Chem. (1992) 35: 734-740 [PMID:1542100]
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
ChEMBL Binding affinity for rodent 5-hydroxytryptamine 5A receptor B 8 pKi <10 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL Binding affinities towards 5-hydroxytryptamine 5A receptor B 8.05 pKi 9 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL Binding affinities towards 5-hydroxytryptamine 6 receptor B 8.16 pKi 6.9 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
ChEMBL Binding affinity against 5-hydroxytryptamine 6 human cloned receptors in HeLa cells B 8.2 pKi 6.31 nM Ki J. Med. Chem. (2003) 46: 5117-5120 [PMID:14613313]
GtoPdb - - 8.4 pKi - - - Mol Pharmacol (1998) 54: 577-583 [PMID:9730917]
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
GtoPdb - - 8.7 pKi - - - Neuropharmacology (1997) 36: 713-20 [PMID:9225298];
Mol Pharmacol (1998) 54: 577-583 [PMID:9730917]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL Binding affinities towards 5-hydroxytryptamine 7 receptor B 8.18 pKi 6.6 nM Ki J. Med. Chem. (2002) 45: 4344-4349 [PMID:12213075]
ChEMBL Binding affinity against 5-hydroxytryptamine 7 human receptors B 8.2 pKi 6.31 nM Ki J. Med. Chem. (2003) 46: 5117-5120 [PMID:14613313]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
ChEMBL Binding affinity at rat 5-hydroxytryptamine 7 receptor. B 8.02 pKi 9.55 nM Ki J. Med. Chem. (2003) 46: 5365-5374 [PMID:14640545]
ChEMBL Binding affinity towards rat 5-hydroxytryptamine 7 receptor B 8.7 pKi 2 nM Ki J. Med. Chem. (2003) 46: 2795-2812 [PMID:12825922]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]