ChEMBL ligand: CHEMBL263881 (Dextrolysergic acid diethylamide, D-lsd, LSD, Lsd-25, Lysergic acid diethylamide, Lysergic acid diethylamide tartrate ci, Lysergide, N,n-diethyllysergamide)
β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] There should be some charts here, you may need to enable JavaScript!
β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Mouse [ChEMBL: CHEMBL3071] [GtoPdb: 214] [UniProtKB: Q61616] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
D3 receptor/Dopamine D3 receptor in Human [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462] There should be some charts here, you may need to enable JavaScript!
D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] There should be some charts here, you may need to enable JavaScript!
D5 receptor/Dopamine D5 receptor in Human [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918] There should be some charts here, you may need to enable JavaScript!
H1 receptor/Histamine H1 receptor in Human [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367] There should be some charts here, you may need to enable JavaScript!
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] There should be some charts here, you may need to enable JavaScript!
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] There should be some charts here, you may need to enable JavaScript!
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] There should be some charts here, you may need to enable JavaScript!
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] 5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994] There should be some charts here, you may need to enable JavaScript!
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] 5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909] There should be some charts here, you may need to enable JavaScript!
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898] There should be some charts here, you may need to enable JavaScript!
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] 5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388] There should be some charts here, you may need to enable JavaScript!
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] 5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL	Binding affinity towards Beta-1 adrenergic receptor	B	6.85	pKi	140	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL	Binding affinity towards Beta-2 adrenergic receptor	B	6.13	pKi	740	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
D1 receptor/Dopamine D1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3071] [GtoPdb: 214] [UniProtKB: Q61616]
ChEMBL	Binding affinities towards Dopamine receptor D1	B	6.74	pKi	180	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Binding affinity against human Dopamine receptor D2 in CHO cells using [125I]iodosulpiride	B	6.9	pKi	125.89	nM	Ki	J Med Chem (2003) 46: 5117-5120 [PMID:14613313]
ChEMBL	Binding affinity towards Dopamine receptor D2	B	6.92	pKi	120	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
D3 receptor/Dopamine D3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL234] [GtoPdb: 216] [UniProtKB: P35462]
ChEMBL	Binding affinity towards Dopamine receptor D3	B	7.57	pKi	27	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
ChEMBL	Binding affinity towards Dopamine receptor D4	B	7.25	pKi	56	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
D5 receptor/Dopamine D5 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1850] [GtoPdb: 218] [UniProtKB: P21918]
ChEMBL	Binding affinity towards Dopamine receptor D5	B	6.47	pKi	340	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
H1 receptor/Histamine H1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL231] [GtoPdb: 262] [UniProtKB: P35367]
ChEMBL	Binding affinity towards Histamine H1 receptor	B	5.81	pKi	1540	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL	Binding affinity against 5-hydroxytryptamine 1A human cloned receptors in HEK293 cells using [3H]8-OH-DPAT as radioligand	B	8.9	pKi	1.26	nM	Ki	J Med Chem (2003) 46: 5117-5120 [PMID:14613313]
ChEMBL	Tested in vitro for its ability to bind to 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand	B	8.96	pKi	1.1	nM	Ki	J Med Chem (2003) 46: 3526-3535 [PMID:12877591]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand	B	8.96	pKi	1.1	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
GtoPdb	-	-	9	pKi	-	-	-	J Med Chem (2002) 45: 4344-9 [PMID:12213075]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL	Binding affinity was measured against 5-hydroxytryptamine 1A receptor by displacement of [3H]8-OH-DPAT by lysergic acid amides	B	8.29	pKi	5.1	nM	Ki	J Med Chem (1995) 38: 958-966 [PMID:7699712]
ChEMBL	Binding affinity of [3H]- -8-OH-DPAT labelled towards Rat Hippocampal 5-hydroxytryptamine 1A receptor using radioligand binding assay	B	8.29	pKi	5.1	nM	Ki	J Med Chem (1996) 39: 2953-2961 [PMID:8709129]
ChEMBL	Affinity in displacing [3H]8-OH-DPAT from rat hippocampal 5-HT1A receptor.	B	8.3	pKi	5.05	nM	Ki	J Med Chem (1992) 35: 203-211 [PMID:1732537]
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 1D receptor alpha using [3H]8-OH-DPAT as radioligand	B	8.41	pKi	3.9	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
5-ht1e receptor/Serotonin 1e (5-HT1e) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2182] [GtoPdb: 4] [UniProtKB: P28566]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 1E receptor	B	7.03	pKi	93	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL	Displacement of [3H]INBMeO from human 5HT2A receptor expressed in human A549 cells	B	8.4	pKi	4	nM	Ki	Bioorg Med Chem (2008) 16: 6116-6123 [PMID:18468904]
ChEMBL	Displacement of [3H]INBMeO from human 5HT2A receptor expressed in human HEK293 cells	B	8.46	pKi	3.5	nM	Ki	Bioorg Med Chem (2008) 16: 6116-6123 [PMID:18468904]
ChEMBL	Binding affinity against 5-hydroxytryptamine 2A receptor human cloned receptors in HEK 293 cells using [3H]ketanserin as radioligand	B	8.5	pKi	3.16	nM	Ki	J Med Chem (2003) 46: 5117-5120 [PMID:14613313]
ChEMBL	Displacement of [3H]ketanserin from human 5HT2A receptor expressed in human HEK293 cells	B	8.51	pKi	3.1	nM	Ki	Bioorg Med Chem (2008) 16: 6116-6123 [PMID:18468904]
ChEMBL	Displacement of [3H]ketanserin from human 5HT2A receptor expressed in human A549 cells	B	8.59	pKi	2.6	nM	Ki	Bioorg Med Chem (2008) 16: 6116-6123 [PMID:18468904]
GtoPdb	-	-	9.4	pKi	-	-	-	J Biol Chem (1996) 271: 14672-5 [PMID:8663249]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL	Binding affinity was measured against 5-hydroxytryptamine 2A receptor by displacement of [3H]- ketanserin by lysergic acid amides	B	8.36	pKi	4.4	nM	Ki	J Med Chem (1995) 38: 958-966 [PMID:7699712]
ChEMBL	Binding affinity of [3H]- ketanserin labelled towards Rat cortical 5-hydroxytryptamine 2A receptor using radioligand binding assay	B	8.36	pKi	4.4	nM	Ki	J Med Chem (1996) 39: 2953-2961 [PMID:8709129]
ChEMBL	In vitro binding to 5-hydroxytryptamine 2A receptor using [125 I]-DOI	B	8.46	pKi	3.5	nM	Ki	J Med Chem (2003) 46: 3526-3535 [PMID:12877591]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]DOI as radioligand	B	8.46	pKi	3.5	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
ChEMBL	Displacement of [125I]DOI from rat 5HT2A receptor	B	8.46	pKi	3.5	nM	Ki	J Med Chem (2006) 49: 4269-4274 [PMID:16821786]
GtoPdb	-	-	8.5	pKi	-	-	-	J Med Chem (2002) 45: 4344-9 [PMID:12213075]
ChEMBL	Tested for its ability to activate phospholipase C by quantification of IP3 at cloned rat 5-hydroxytryptamine 2A receptor	B	8.01	pEC50	9.8	nM	EC50	J Med Chem (2003) 46: 3526-3535 [PMID:12877591]
ChEMBL	Activity at rat 5HT2A receptor assessed as 5-HT-stimulated IP3 accumulation	F	8.01	pEC50	9.8	nM	EC50	J Med Chem (2006) 49: 4269-4274 [PMID:16821786]
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 2B receptor using [125I]DOI as radioligand	B	7.52	pKi	30	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
GtoPdb	Biased for β-arrestin sihnalling.	-	8.43	pKi	-	-	-	Science (2013) 340: 615-9 [PMID:23519215]
5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994]
GtoPdb	-	-	8.3	pKi	-	-	-	J Med Chem (2002) 45: 4344-9 [PMID:12213075]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335]
ChEMBL	Binding affinity against 5-hydroxytryptamine 2C receptor human cloned receptors in HEK 293 cells using [3H]mesulergine as radioligand	B	8.3	pKi	5.01	nM	Ki	J Med Chem (2003) 46: 5117-5120 [PMID:14613313]
GtoPdb	-	-	8.6	pKi	-	-	-	Synapse (2000) 35: 144-150 [PMID:10611640]
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL324] [GtoPdb: 8] [UniProtKB: P08909]
ChEMBL	In vitro binding to 5-hydroxytryptamine 2C receptor using [125 I]-DOI	B	8.26	pKi	5.5	nM	Ki	J Med Chem (2003) 46: 3526-3535 [PMID:12877591]
ChEMBL	Binding affinity towards 5-hydroxytryptamine 2C receptor using [125I]DOI as radioligand	B	8.26	pKi	5.5	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
ChEMBL	Displacement of [125I]DOI from rat 5HT2C receptor	B	8.26	pKi	5.5	nM	Ki	J Med Chem (2006) 49: 4269-4274 [PMID:16821786]
ChEMBL	Compound was tested for binding affinity towards 5-hydroxytryptamine 1C receptor from frontal cortical regions of male Sprague-Dawley rat homogenates, using [3H]mesulergine as radioligand	B	8.42	pKi	3.8	nM	Ki	J Med Chem (1992) 35: 734-740 [PMID:1542100]
5-HT5A receptor/Serotonin 5a (5-HT5a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3426] [GtoPdb: 10] [UniProtKB: P47898]
ChEMBL	Binding affinity for rodent 5-hydroxytryptamine 5A receptor	B	8	pKi	<10	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]
ChEMBL	Binding affinities towards 5-hydroxytryptamine 5A receptor	B	8.05	pKi	9	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406]
ChEMBL	Binding affinities towards 5-hydroxytryptamine 6 receptor	B	8.16	pKi	6.9	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
ChEMBL	Binding affinity against 5-hydroxytryptamine 6 human cloned receptors in HeLa cells	B	8.2	pKi	6.31	nM	Ki	J Med Chem (2003) 46: 5117-5120 [PMID:14613313]
GtoPdb	-	-	8.4	pKi	-	-	-	Mol Pharmacol (1998) 54: 577-583 [PMID:9730917]
5-HT6 receptor in Rat [GtoPdb: 11] [UniProtKB: P31388]
GtoPdb	-	-	8.7	pKi	-	-	-	Neuropharmacology (1997) 36: 713-20 [PMID:9225298]; Mol Pharmacol (1998) 54: 577-583 [PMID:9730917]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969]
ChEMBL	Binding affinities towards 5-hydroxytryptamine 7 receptor	B	8.18	pKi	6.6	nM	Ki	J Med Chem (2002) 45: 4344-4349 [PMID:12213075]
ChEMBL	Binding affinity against 5-hydroxytryptamine 7 human receptors	B	8.2	pKi	6.31	nM	Ki	J Med Chem (2003) 46: 5117-5120 [PMID:14613313]
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3223] [GtoPdb: 12] [UniProtKB: P32305]
ChEMBL	Binding affinity at rat 5-hydroxytryptamine 7 receptor.	B	8.02	pKi	9.55	nM	Ki	J Med Chem (2003) 46: 5365-5374 [PMID:14640545]
ChEMBL	Binding affinity towards rat 5-hydroxytryptamine 7 receptor	B	8.7	pKi	2	nM	Ki	J Med Chem (2003) 46: 2795-2812 [PMID:12825922]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]