MRS1066 [Ligand Id: 396] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL76874 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine receptor A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| GtoPdb | - | - | 4.4 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
| ChEMBL | Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]PIA displacement. | B | 4.45 | pKi | 35600 | nM | Ki | J Med Chem (1996) 39: 2293-2301 [PMID:8691424] |
| A3 receptor/Adenosine receptor A3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Binding affinity against human adenosine A3 receptor in HEK293 cells using [125I]AB-MECA 21680 radioligand. | B | 5.94 | pKi | 1160 | nM | Ki | J Med Chem (1996) 39: 2293-2301 [PMID:8691424] |
| A3 receptor/Adenosine receptor A3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] | ||||||||
| ChEMBL | Binding affinity for [125I]AB-MECA against rat Adenosine A3 receptor | B | 4.91 | pKi | 12300 | nM | Ki | J Med Chem (1996) 39: 2293-2301 [PMID:8691424] |
| A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| GtoPdb | - | - | 4.5 | pKi | - | - | - | J Med Chem (1996) 39: 2293-301 [PMID:8691424] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
