curcumin [Ligand Id: 7000] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL140
  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
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  • butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
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  • CDGSH iron-sulfur domain-containing protein 1 in Human [ChEMBL: CHEMBL1795168] [UniProtKB: Q9NZ45]
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  • CREB binding protein/CREB-binding protein in Human [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
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  • epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
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  • hydroxysteroid 17-beta dehydrogenase 2/Estradiol 17-beta-dehydrogenase 2 in Human [ChEMBL: CHEMBL2789] [GtoPdb: 3094] [UniProtKB: P37059]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Rat [ChEMBL: CHEMBL3669] [GtoPdb: 2030] [UniProtKB: P18266]
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  • E1A binding protein p300/Histone acetyltransferase p300 in Human [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472]
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  • nuclear factor, erythroid 2 like 2/Nuclear factor erythroid 2-related factor 2 in Human [ChEMBL: CHEMBL1075094] [GtoPdb: 3057] [UniProtKB: Q16236]
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  • p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153]
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  • SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Mouse [ChEMBL: CHEMBL3074] [GtoPdb: 2206] [UniProtKB: P05480]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate pretreated for 15 mins followed by substrate addition measured for 2 mins by DTNB reagent based spectrophotometric method B 5.3 pIC50 >5000 nM IC50 Eur J Med Chem (2017) 130: 139-153 [PMID:28242549]
Aminopeptidase N in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1907] [GtoPdb: 1560] [UniProtKB: P15144]
ChEMBL Inhibition of APN (unknown origin) B 4.81 pIC50 15500 nM IC50 J Med Chem (2018) 61: 6468-6490 [PMID:29630364]
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL Inhibition of HFIP-pretreated amyloid beta (1 to 42 residues) (unknown origin) self aggregation after 24 hrs by ThT-based fluorometric method B 4.65 pIC50 22510 nM IC50 Eur J Med Chem (2017) 136: 36-51 [PMID:28478343]
ChEMBL Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation after 48 hrs by thioflavin-T fluorescence assay B 4.66 pIC50 21810 nM IC50 Eur J Med Chem (2017) 125: 736-750 [PMID:27721157]
ChEMBL Inhibition of self-induced amyloid beta (1 to 42) (unknown origin) aggregation incubated for 48 hrs measured after 5 mins by thioflavin-T fluorescence assay B 4.66 pIC50 21810 nM IC50 Bioorg. Med. Chem. (2016) 24: 3829-3841 [PMID:27353888]
ChEMBL Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation incubated for 24 hrs under dark condition by thioflavin-T based fluorometric assay B 4.73 pIC50 18730 nM IC50 Eur J Med Chem (2017) 127: 174-186 [PMID:28061347]
ChEMBL Inhibition of HFIP-pretreated amyloid beta (1 to 42) (unknown origin) self-induced aggregation after 24 hrs by thioflavin-T fluorescence assay B 4.73 pIC50 18730 nM IC50 Bioorg Med Chem (2018) 26: 5759-5765 [PMID:30360953]
ChEMBL Inhibition of self-mediated amyloid beta (1 to 42) (unknown origin) aggregation after 48 hrs by thioflavin T fluorescence assay B 4.74 pIC50 18250 nM IC50 Eur J Med Chem (2016) 122: 17-26 [PMID:27343850]
ChEMBL Inhibition of amyloid beta (1 to 42) (unknown origin) self-aggregation after 24 hrs by thioflavin-T fluorescence assay B 4.82 pIC50 14990 nM IC50 Eur J Med Chem (2018) 151: 351-362 [PMID:29635167]
ChEMBL Inhibition of self-mediated amyloid beta (1 to 42) (unknown origin) aggregation after 10 hrs by thioflavin T based fluorometric assay B 4.95 pIC50 11300 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 747-750 [PMID:26783181]
ChEMBL Inhibition of human amyloid beta (1 to 42) aggregation after 46 to 48 hrs by Thioflavin T fluorescence assay B 5 pIC50 10000 nM IC50 J Nat Prod (2017) 80: 278-289 [PMID:28128562]
ChEMBL Inhibition of HFIP-induced human recombinant amyloid beta (1 to 42 residues) aggregation expressed in Escherichia coli measured over 24 hrs by ThT-based fluorescence spectroscopic method B 5 pIC50 9900 nM IC50 Eur J Med Chem (2017) 126: 823-843 [PMID:27951490]
ChEMBL Inhibition of HFIP-pretreated amyloid beta (1 to 42 residues) (unknown origin) aggregation after 24 hrs by ThT fluorescence assay B 5.05 pIC50 9000 nM IC50 Bioorg Med Chem Lett (2017) 27: 1405-1411 [PMID:28216401]
ChEMBL Inhibition of Abeta42 (unknown origin) aggregation measured after 24 hrs by ThT fluorescence assay B 5.05 pIC50 9000 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3330-3335 [PMID:27256911]
ChEMBL Inhibition of amyloid beta (1 to 42 residues) (unknown origin) aggregation after 24 hrs by thioflavin T fluorescence assay B 5.27 pIC50 5400 nM IC50 Bioorg Med Chem Lett (2016) 26: 5024-5028 [PMID:27624076]
ChEMBL Inhibition of amyloid beta (1 to 42) fibrillization (unknown origin) incubated with agitation for 1 min every hr measured over 80 hrs by thioflavin-T assay B 5.47 pIC50 3400 nM IC50 Eur J Med Chem (2018) 158: 393-404 [PMID:30227353]
ChEMBL Inhibition of HFIP-induced human recombinant amyloid beta (1 to 40 residues) aggregation expressed in Escherichia coli measured over 24 hrs by ThT-based fluorescence spectroscopic method B 5.48 pIC50 3300 nM IC50 Eur J Med Chem (2017) 126: 823-843 [PMID:27951490]
ChEMBL Inhibition of self-induced amyloid beta 42 (unknown origin) aggregation measured for 24 hrs by thioflavin T-based fluorescence spectroscopic analysis B 5.51 pIC50 3100 nM IC50 ACS Med. Chem. Lett. (2016) 7: 502-507 [PMID:27190601]
ChEMBL Inhibition of self-induced amyloid beta 40 (unknown origin) aggregation measured for 24 hrs by thioflavin T-based fluorescence spectroscopic analysis B 5.82 pIC50 1500 nM IC50 ACS Med. Chem. Lett. (2016) 7: 502-507 [PMID:27190601]
ChEMBL Inhibition of amyloid beta (1 to 40 residues) (unknown origin) fibril formation by thioflavin-T fluorescence based assay B 6 pIC50 1000 nM IC50 J Med Chem (2017) 60: 1620-1637 [PMID:28074653]
ChEMBL Inhibition of human amyloid beta (1 to 40) aggregation after 1 hr by thioflavin-T fluorescence assay B 6.1 pIC50 800 nM IC50 J Nat Prod (2017) 80: 278-289 [PMID:28128562]
ChEMBL Inhibition of amyloid beta (1 to 42) aggregation (unknown origin) by ThT fluorescence assay B 6.2 pIC50 630 nM IC50 Bioorg Med Chem (2017) 25: 1195-1201 [PMID:28043778]
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL Inhibition of human serum BuChE using butylthiocholine chloride as substrate pretreated for 15 mins followed by substrate addition measured for 2 mins by DTNB reagent based spectrophotometric method B 5.3 pIC50 >5000 nM IC50 Eur J Med Chem (2017) 130: 139-153 [PMID:28242549]
CDGSH iron-sulfur domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795168] [UniProtKB: Q9NZ45]
ChEMBL Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by Cheng-Prusoff analysis B 7 pKi 101 nM Ki Bioorg Med Chem Lett (2016) 26: 5350-5353 [PMID:27687671]
ChEMBL Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichia coli BL21 by scintillation proximity assay B 5.63 pIC50 2360 nM IC50 Bioorg Med Chem Lett (2016) 26: 5350-5353 [PMID:27687671]
Coagulation factor III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4081] [UniProtKB: P13726]
ChEMBL Inhibition of LPS-induced tissue factor procoagulant activity in human THP1 cells preincubated for 1 hr followed by LPS addition measured after 5 hrs using factor 10a chromogenic substrate in presence of prothrombin complex B 7.88 pIC50 13.16 nM IC50 Bioorg Med Chem Lett (2017) 27: 1026-1030 [PMID:28109788]
CREB binding protein/CREB-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5747] [GtoPdb: 2734] [UniProtKB: Q92793]
ChEMBL Inhibition of recombinant CBP (unknown origin) expressed in baculovirus expression system using histone substrate after 10 mins by liquid scintillation counting method in presence of [3H]acetyl-CoA B 4.6 pIC50 25000 nM IC50 J. Med. Chem. (2016) 59: 1249-1270 [PMID:26701186]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL Time-Resolved Fluorescence Assay: The kinase activity of EGFR was detected according to time-resolved fluorescence detection technology to evaluate automatic phosphorylation levels. The test compound was dissolved in 100% DMSO, diluted with 25 mM HEPES (pH=7.4) to the desired concentration, added into each well with 10 μL of the test compounds and 10 μL solution containing 5 ng EGFR, then cultured for 10 min at room temperature using the recombinase diluted by 100 mM HEPES with a dilution ratio of 1:80, subsequently added with 10 μL solution containing 20 mM HEPES, 2 mM MnCl2, 100 μM Na3VO4, 1 mM DTT buffer, and 20 μL of 0.1 mM ATP and 50 mM MgCl2 and cultured for 1 h. The positive group in each plate was added with ATP-MgCl2 enzyme, the negative control group without adding with ATP-MgCl2 enzyme, the liquid was sucked out completely after cultured for 1 h, and each well was washed with buffer for three times. The wells were added with 75 μL anti-phosphorylated tyrosine antibody containing 400 ng europium labeling and cultured 1 h, washed, then added with enhancing solution. At the excitation wavelength 340 nm and the emission wavelength 615 nm, the fluorescence intensities were detected by using Victor type 2 time-resolved luminoscope, wherein the inhibitory rate of the compound on automatic phosphorylation: the inhibitory rate of autophosphorylation=100%−[(negative control)/(positive control−negative control)]. B 5.06 pIC50 8650 nM IC50 US-9409845-B2. Alpha-(3,5-dimethoxybenzylidene)-alpha′-hydrocarbyl methylene cyclic ketone and preparation method thereof (2016)
hydroxysteroid 17-beta dehydrogenase 2/Estradiol 17-beta-dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2789] [GtoPdb: 3094] [UniProtKB: P37059]
ChEMBL Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation counting method B 5.76 pIC50 1730 nM IC50 J Nat Prod (2017) 80: 965-974 [PMID:28319389]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL Inhibition of human recombinant GSK3-beta using prephosphorylated polypeptide as substrate incubated for 30 mins by Glo-type luminescence assay B 4.75 pIC50 17950 nM IC50 J. Med. Chem. (2016) 59: 531-544 [PMID:26696252]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3669] [GtoPdb: 2030] [UniProtKB: P18266]
ChEMBL Inhibition of recombinant rat N-terminal GST-tagged GSK3beta expressed in Escherichia coli assessed as reduction in tau phosphorylation preincubated for 30 mins followed by tau protein addition measured after 1 hr by ELISA B 7.18 pIC50 66 nM IC50 J Med Chem (2017) 60: 1620-1637 [PMID:28074653]
E1A binding protein p300/Histone acetyltransferase p300 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472]
GtoPdb - - 4.6 pIC50 25000 nM IC50 J. Biol. Chem. (2004) 279: 51163-71 [PMID:15383533]
ChEMBL Inhibition of recombinant p300 (unknown origin) expressed in baculovirus expression system using histone substrate after 10 mins by liquid scintillation counting method in presence of [3H]acetyl-CoA B 4.6 pIC50 25000 nM IC50 J. Med. Chem. (2016) 59: 1249-1270 [PMID:26701186]
ChEMBL Inhibition of recombinant human p300 catalytic domain (1284 to 1673 residues) using histone H3 peptide substrate after 1 hr by liquid scintillation counting method in presence of [3H]acetyl-CoA B 5.19 pIC50 6500 nM IC50 J. Med. Chem. (2016) 59: 1249-1270 [PMID:26701186]
Microtubule-associated protein tau in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293224] [UniProtKB: P10636]
ChEMBL Inhibition of tau (unknown origin) fibril formation by fluorescence assay B 4.89 pIC50 13000 nM IC50 J Med Chem (2017) 60: 1620-1637 [PMID:28074653]
ChEMBL Inhibition of tau (unknown origin) fibril formation by thioflavin-T fluorescence based assay B 5.46 pIC50 3500 nM IC50 J Med Chem (2017) 60: 1620-1637 [PMID:28074653]
ChEMBL Inhibition of recombinant human TAU three-repeat microtubule-binding domain aggregation expressed in Escherichia coli after 16 hrs by thioflavin T fluorescence assay B 5.52 pIC50 3000 nM IC50 Bioorg Med Chem Lett (2016) 26: 5024-5028 [PMID:27624076]
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL Inhibition of recombinant human MAO-A using p-tyramine as substrate assessed as H2O2 production preincubated for 15 mins followed by substrate addition measured for 15 mins by amplex red assay B 6.15 pKi 710 nM Ki ACS Med. Chem. Lett. (2016) 7: 56-61 [PMID:26819666]
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL Inhibition of recombinant human MAO-B using p-tyramine as substrate assessed as H2O2 production preincubated for 15 mins followed by substrate addition measured for 15 mins by amplex red assay B 4.67 pKi 21500 nM Ki ACS Med. Chem. Lett. (2016) 7: 56-61 [PMID:26819666]
nuclear factor, erythroid 2 like 2/Nuclear factor erythroid 2-related factor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075094] [GtoPdb: 3057] [UniProtKB: Q16236]
ChEMBL Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay B 4.68 pEC50 21000 nM EC50 Eur J Med Chem (2018) 143: 854-865 [PMID:29223100]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 24 hrs by [3H]hypoxanthine labeling method F 4.6 pIC50 25000 nM IC50 MedChemComm (2016) 7: 214-223
mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684]
ChEMBL Inhibition of mPGES1 in human A549 cell microsomal membrane using pGH2 as substrate pretreated for 15 mins followed by substrate addition and measured after 1 min by RP-HPLC method B 6.52 pIC50 300 nM IC50 Eur J Med Chem (2018) 153: 2-28 [PMID:29329790]
ChEMBL Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 preincubated for 15 mins by HPLC analysis B 6.66 pIC50 220 nM IC50 J. Nat. Prod. (2015) 78: 2867-2879 [PMID:26588603]
ChEMBL Inhibition of microsomal PGES1 in ILbeta-stimulated human A549 cells using PGH2 as substrate preincubated for 15 mins followed by substrate addition measured after 1 min by RP-HPLC analysis B 6.7 pIC50 200 nM IC50 MedChemComm (2015) 6: 2081-2123
p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153]
ChEMBL Inhibition of recombinant human PAK1 by ADP-Glo kinase assay B 4.8 pIC50 16000 nM IC50 Eur J Med Chem (2017) 142: 229-243 [PMID:28814374]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3074] [GtoPdb: 2206] [UniProtKB: P05480]
ChEMBL Inhibition of Src in mouse BV2 cells assessed as suppression of LPS-induced NO release preincubated for 1 hr followed by LPS addition measured after 24 hrs by Griess assay B 5.66 pIC50 2200 nM IC50 J Med Chem (2016) 59: 9062-9079 [PMID:27617803]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]