Synonyms: ARV-471 | ARV471 | compound 341 [WO2018102725A1]
Compound class:
Synthetic organic
Comment: Vepdegrestrant (ARV471) is a bifunctional compound that is estrogen receptor (ER) degrader (PROTAC) [1]. It uses a cereblon-based binder to direct ER protein degradation. ARV471 is being investigated for potential to treat breast cancer.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
3-[6-[4-[[1-[4-[(1R,2S)-6-hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl]phenyl]piperidin-4-yl]methyl]piperazin-1-yl]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione |
International Nonproprietary Names ![]() |
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INN number | INN |
12157 | vepdegestrant |
Synonyms ![]() |
ARV-471 | ARV471 | compound 341 [WO2018102725A1] |
Database Links ![]() |
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GtoPdb PubChem SID | 441604883 |
PubChem CID | 134579471 |
Search Google for chemical match using the InChIKey | TZZDVPMABRWKIZ-MFTLXVFQSA-N |
Search Google for chemicals with the same backbone | TZZDVPMABRWKIZ |
Search PubMed clinical trials | vepdegestrant |
Search PubMed titles | vepdegestrant |
Search PubMed titles/abstracts | vepdegestrant |
UniChem Compound Search for chemical match using the InChIKey | TZZDVPMABRWKIZ-MFTLXVFQSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | TZZDVPMABRWKIZ-MFTLXVFQSA-N |