compound 1 [PMID: 21742770] [Ligand Id: 8190] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2203524
  • serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
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  • protein kinase A in Human [GtoPdb: 1694]
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  • aurora kinase B in Human [GtoPdb: 1937] [UniProtKB: Q96GD4]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3]
GtoPdb - - 8.15 pIC50 7 nM IC50 Cancer Res (2011) 71: 5818-26 [PMID:21742770]
ChEMBL Inhibition of N-terminal 6His-tagged full length human recombinant STK33 using myelin basic protein as substrate incubated for 15 mins before initiation of kinase reaction measured after 1 hr by ADP-glo assay B 8.15 pIC50 7 nM IC50 ACS Med Chem Lett (2012) 3: 1034-1038 [PMID:23256033]
protein kinase A in Human [GtoPdb: 1694]
GtoPdb - - 6.71 pIC50 196 nM IC50 ACS Med Chem Lett (2012) 3: 1034-1038 [PMID:23256033]
aurora kinase B in Human [GtoPdb: 1937] [UniProtKB: Q96GD4]
GtoPdb - - 8.55 pIC50 2.8 nM IC50 ACS Med Chem Lett (2012) 3: 1034-1038 [PMID:23256033]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]