ChEMBL ligand: CHEMBL389621 (Cortifoam, Nutracort, Ala-scalp, Acetasol hc, Micort-HC, Terra-Cortril, Proctofoam hc, Alkindi sprinkle, Efcortelan p, Alphaderm, Texacort, Cortef, U-Cort, Cipro hc, Mildison lipocream, Hc #1, Neo-Cortef, Hydrocort in calamine oily, Hydrocortisone in absorbase, Cortisol, FLEXICORT, Synacort, Anflam, Uniroid, Hydro-rx, Zenoxone, Dioderm, Hc #4, Otosporin, Anusol soothing relief, Exe-cort, Nogenic hc, Dermacort, Daktacort hydrocort, Aeroseb-hc, Tri-cicatrin, Eurax-hc, Gregoderm, H-cort, Quinocort, Penecort, Hytone, Colocort, Calmurid hc, Cobadex, Ophthocort, Proctosedyl, Corlan, Cort-dome, Eldecort, Dome-cort, Hc (hydrocortisone), Cor-Oticin, Germoloids hc, Anucort-Hc, Hydrocortisone, Terra-cortril nystatin, Cetacort, Perinal, Xyloproct, Uniroid hc, Hydrocort in cetomacrogol for a, Daktacort, Hydrocort in wte soft paraf, Flexicort, Hydroderm, Beta-hc, Timodine, Epicort, Topisone, Medicort, Plenadren, Evacort, Eurax-hydrocort, Glycort, Hi-cor, Otoseptil, Dermaspray demang, Sential hc, Ala-cort, Cortril, Derma care hydrocort, Cortenema, Anusol-Hc, Nystaform-hc, Anugesic hc, Cortenem, Jungle for, Proctocream hc, Hydrocortone, NSC-10483, Balneol-hc, Nybadex, Timocort, Econacort, Locoid, Hydroderm hc, Acticort, Stie-cort, Anusol hc, Anusol plus hc, Proctocort, Canesten hc)
Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185] There should be some charts here, you may need to enable JavaScript!
Glucocorticoid receptor in Human [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] Glucocorticoid receptor in Mouse [ChEMBL: CHEMBL3144] [GtoPdb: 625] [UniProtKB: P06537] Glucocorticoid receptor in Rat [ChEMBL: CHEMBL3368] [GtoPdb: 625] [UniProtKB: P06536] There should be some charts here, you may need to enable JavaScript!
Mineralocorticoid receptor in Human [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] P-glycoprotein 1 in Mouse [ChEMBL: CHEMBL3467] [UniProtKB: P06795] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 3 in Mouse [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL	In silico binding affinity to human corticosteriod binding globulin	B	6.88	pKd	6.88	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	7.88	pKi	13.18	nM	Ki	J Med Chem (2004) 47: 2732-2742 [PMID:15139751]
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	B	7.92	pKi	12	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	B	7.59	pIC50	26	nM	IC50	DrugMatrix in vitro pharmacology data
GtoPdb	-	-	8	pIC50	-	-	-	Eur J Pharmacol (1993) 247: 145-54 [PMID:8282004]; FEBS Lett (1999) 464: 9-13 [PMID:10611474]; J Biol Chem (2000) 275: 19041-9 [PMID:10747884]
Glucocorticoid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3144] [GtoPdb: 625] [UniProtKB: P06537]
ChEMBL	Displacement of 1 x 10'-8 M of [1,2,3-3H]-triamcinolone acetonide from glucocorticoid receptor in soluble fraction of mouse L929 cells after 20 hrs	B	7.37	pKd	43	nM	Kd	J Med Chem (1977) 20: 1134-1139 [PMID:926113]
Glucocorticoid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3368] [GtoPdb: 625] [UniProtKB: P06536]
ChEMBL	Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with CCL2-promoter luciferase plasmid construct assessed as reduction in IL-1 beta induced inflammation by luciferase reporter gene assay	B	7.6	pIC50	25.12	nM	IC50	ACS Med Chem Lett (2021) 12: 1568-1577 [PMID:34676039]
ChEMBL	Agonist activity at glucocorticoid receptor in rat INS-1 832/13 cells transfected with 3XGRE-promoter luciferase plasmid construct assessed as induction of receptor transactivation by luciferase reporter gene assay	B	5.6	pEC50	2511.89	nM	EC50	ACS Med Chem Lett (2021) 12: 1568-1577 [PMID:34676039]
Mineralocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235]
ChEMBL	Binding affinity to MR (unknown origin)	B	9.3	pKd	0.5	nM	Kd	J Med Chem (2017) 60: 2629-2650 [PMID:28051871]
GtoPdb	-	-	9.95	pIC50	-	-	-	Eur J Pharmacol (1993) 247: 145-54 [PMID:8282004]; FEBS Lett (1999) 464: 9-13 [PMID:10611474]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
P-glycoprotein 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3467] [UniProtKB: P06795]
ChEMBL	Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ABCB1/P-glycoprotein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447]
ChEMBL	Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL	TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells	F	4.3	pIC50	>50000	nM	IC50	J Med Chem (2003) 46: 1716-1725 [PMID:12699389]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat Chem Biol (2009) 5: 765-771 [PMID:19734910]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL	Binding affinity towards human testosterone binding globulin.	B	5.2	pKd	5.2	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin	B	6.2	pKd	630.96	nM	Kd	J Med Chem (2008) 51: 2047-2056 [PMID:18330978]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]