cortisol [Ligand Id: 2868] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL389621 (Neo-Cortef, Uniroid, Eldecort, Nystaform-HC, Colocort, Cortifoam, Hytone, Anucort-Hc, Epicort, Proctocort, Cort-Dome, Hi-Cor, Daktacort, Sential HC, Balneol-Hc, Beta-Hc, Timocort, Hydrocortisone, Cortef, Dome-Cort, Dermacort, Stie-Cort, Cor-Oticin, Cortenema, Anusol hc, Zenoxone, Anusol Soothing Relief, Alphaderm, Hydroderm, Hydrocort In Calamine Oily, Hc (hydrocortisone), Corlan, Proctosedyl, Tri-Cicatrin, Proctofoam HC, Cipro HC, Hydrocortone, Cortisol, Acetasol HC, U-Cort, Terra-Cortril Nystatin, Otosporin, Plenadren, Hydroderm HC, Cobadex, Nogenic hc, Anflam, Ala-Scalp, Penecort, Timodine, Efcortelan P, Flexicort, Evacort, Synacort, Micort-HC, Xyloproct, Derma Care Hydrocort, Dermaspray Demang, Daktacort Hydrocort, NSC-10483, Hydrocort In Cetomacrogol For A, Topisone, Gregoderm, H-Cort, Acticort, Locoid, Quinocort, Hydro-Rx, Canesten HC, Hydrocort In Wte Soft Paraf, Hc45, Terra-Cortril, Econacort, Mildison Lipocream, Germoloids HC, Anusol-Hc, Texacort, Otoseptil, Ala-Cort, Eurax-Hc, Uniroid Hc, Nybadex, Exe-Cort, Calmurid HC, Aeroseb-Hc, Medicort, Cetacort, Hc #1, Perinal, Jungle For, Eurax-Hydrocort, Hydrocortisone In Absorbase, Cortenem, Proctocream HC, Anugesic HC, Dioderm, Ophthocort, Nutracort, Cortril, Glycort, Hc #4, Anusol Plus HC)
  • Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
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  • Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL In silico binding affinity to human corticosteriod binding globulin B 6.88 pKd 6.88 - -Log Kdiss J. Med. Chem. (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL Binding affinity to human CBG receptor (corticosteroid-binding globulins) B 7.88 pKi 13.18 nM Ki J. Med. Chem. (2004) 47: 2732-2742 [PMID:15139751]
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) B 7.92 pKi 12 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) B 7.59 pIC50 26 nM IC50 DrugMatrix in vitro pharmacology data
GtoPdb - - 8 pIC50 - - - Eur. J. Pharmacol. (1993) 247: 145-54 [PMID:8282004];
FEBS Lett. (1999) 464: 9-13 [PMID:10611474];
J. Biol. Chem. (2000) 275: 19041-9 [PMID:10747884]
Glucocorticoid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3144] [GtoPdb: 625] [UniProtKB: P06537]
ChEMBL Displacement of 1 x 10'-8 M of [1,2,3-3H]-triamcinolone acetonide from glucocorticoid receptor in soluble fraction of mouse L929 cells after 20 hrs B 7.37 pKd 43 nM Kd J. Med. Chem. (1977) 20: 1134-1139 [PMID:926113]
Mineralocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1994] [GtoPdb: 626] [UniProtKB: P08235]
ChEMBL Binding affinity to MR (unknown origin) B 9.3 pKd 0.5 nM Kd J Med Chem (2017) 60: 2629-2650 [PMID:28051871]
GtoPdb - - 9.95 pIC50 - - - Eur. J. Pharmacol. (1993) 247: 145-54 [PMID:8282004];
FEBS Lett. (1999) 464: 9-13 [PMID:10611474]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC F 4.3 pIC50 >50000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay F 4.3 pIC50 >50000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells F 4.3 pIC50 >50000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
P-glycoprotein 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3467] [UniProtKB: P06795]
ChEMBL Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay F 4.3 pIC50 >50000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells F 4.3 pIC50 >50000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ABCB1/P-glycoprotein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447]
ChEMBL Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay F 4.3 pIC50 >50000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
ChEMBL TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells F 4.3 pIC50 >50000 nM IC50 J. Med. Chem. (2003) 46: 1716-1725 [PMID:12699389]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL Binding affinity towards human testosterone binding globulin. B 5.2 pKd 5.2 - -Log Kdiss J. Med. Chem. (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin B 6.2 pKd 630.96 nM Kd J. Med. Chem. (2008) 51: 2047-2056 [PMID:18330978]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]