mafenide [Ligand Id: 12697] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL419 (4-homosulfanilamide, D06BA03, Mafenida, Mafenide, NSC-34632, Sulfamylon) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] | ||||||||
| ChEMBL | Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.87 | pKi | 13600 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] | ||||||||
| ChEMBL | Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay | B | 7.08 | pKi | 82.5 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay | B | 7.08 | pKi | 82.5 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] | ||||||||
| ChEMBL | Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay | B | 6.01 | pKi | 973 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] | ||||||||
| ChEMBL | Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 6.46 | pKi | 350 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] | ||||||||
| ChEMBL | Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay | B | 4.51 | pKi | 30700 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| Carbonic anhydrase in Methanosarcina thermophila (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3932] [UniProtKB: P40881] | ||||||||
| ChEMBL | Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila | B | 5.07 | pKi | 8500 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| ChEMBL | Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila | B | 6.46 | pKi | 350 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] | ||||||||
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 6.29 | pKi | 508 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Carbonic anhydrase in Methanobacterium thermoautotrophicum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3926] [UniProtKB: Q50565] | ||||||||
| ChEMBL | Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum | B | 4.55 | pKi | 28500 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] | ||||||||
| ChEMBL | Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay | B | 5.96 | pKi | 1109 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 5.96 | pKi | 1109 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] | ||||||||
| ChEMBL | Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | B | 6.06 | pKi | 865 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020] |
| Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615] | ||||||||
| ChEMBL | Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay | B | 6.36 | pKi | 433 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855] | ||||||||
| ChEMBL | Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay | B | 6.06 | pKi | 873 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of Helicobacter pylori recombinant CA | B | 6.08 | pKi | 830 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay | B | 6.01 | pKi | 970 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] | ||||||||
| ChEMBL | Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 4.73 | pKi | 18490 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] | ||||||||
| ChEMBL | Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 6.69 | pKi | 202 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of cytosolic carbonic anhydrase 1 esterase activity isolated from human serum using 4-nitrophenylacetate as substrate measured over 3 mins by spectrophotometric analysis | B | 4.38 | pKi | 41910 | nM | Ki | Bioorg Med Chem (2015) 23: 7353-7358 [PMID:26534780] |
| ChEMBL | Inhibition of cloned isozyme, human carbonic anhydrase I | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775] |
| ChEMBL | Inhibition of cloned human cytosolic isozyme Carbonic anhydrase I | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2004) 47: 1272-1279 [PMID:14971907] |
| ChEMBL | Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method. | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I (CA1) | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2000) 43: 292-300 [PMID:10649985] |
| ChEMBL | Inhibition of human carbonic anhydrase I (CAI) | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 1117-1120 [PMID:10843231] |
| ChEMBL | Inhibitory activity against human cloned carbonic anhydrase isozyme I (hCA I, cytosolic form). | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (1999) 42: 2641-2650 [PMID:10411484] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase I (CA1) | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (1999) 42: 3690-3700 [PMID:10479300] |
| ChEMBL | Inhibitory activity against Human carbonic anhydrase I | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2002) 45: 1466-1476 [PMID:11906288] |
| ChEMBL | Ki value against human carbonic anhydrase I | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895] |
| ChEMBL | Ki value against human carbonic anhydrase I (hCA I) | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I (hCAI) | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli BL21 | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I at 0.09 uM | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase I | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human recombinant CA1 | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2010) 53: 2913-2926 [PMID:20201556] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5 | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human esterase activity of carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins by spectrophotometric analysis | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2013) 21: 1522-1525 [PMID:22974493] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1941-1946 [PMID:26972117] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I (hCA I) by using esterase assay method | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157] |
| ChEMBL | Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 4.6 | pKi | 25000 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of carbonic anhydrase 2 assessed as inhibition of carbon dioxide hydration | B | 2.23 | pKi | 2.23 | - | logKi | Eur J Med Chem (2009) 44: 3439-3444 [PMID:19303173] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II at 0.01 uM | B | 3.77 | pKi | 170000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| ChEMBL | Inhibition of human esterase activity of carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins by spectrophotometric analysis | B | 4.77 | pKi | 17100 | nM | Ki | Bioorg Med Chem (2013) 21: 1522-1525 [PMID:22974493] |
| ChEMBL | Inhibition of cytosolic carbonic anhydrase 2 esterase activity isolated from human serum using 4-nitrophenylacetate as substrate measured over 3 mins by spectrophotometric analysis | B | 6.21 | pKi | 612 | nM | Ki | Bioorg Med Chem (2015) 23: 7353-7358 [PMID:26534780] |
| ChEMBL | Inhibition of human carbonic anhydrase II | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II (CA2) | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2000) 43: 292-300 [PMID:10649985] |
| ChEMBL | Inhibition of human carbonic anhydrase II (hCA II) | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 1117-1120 [PMID:10843231] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase II | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (1999) 42: 2641-2650 [PMID:10411484] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (1999) 42: 3690-3700 [PMID:10479300] |
| ChEMBL | Inhibitory activity against Human carbonic anhydrase II | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2002) 45: 1466-1476 [PMID:11906288] |
| ChEMBL | Ki value against human carbonic anhydrase II | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895] |
| ChEMBL | Ki value against human carbonic anhydrase II (hCA II) | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II (hCAII) | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21 | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase II | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325] |
| ChEMBL | Inhibitory activity against human recombinant cytosolic CA2 | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human recombinant CA2 | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2010) 53: 2913-2926 [PMID:20201556] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5 | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1941-1946 [PMID:26972117] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| ChEMBL | Inhibition of cloned isozyme, human carbonic anhydrase II | B | 6.77 | pKi | 170 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775] |
| ChEMBL | Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C | B | 6.77 | pKi | 170 | nM | Ki | J Med Chem (2004) 47: 1272-1279 [PMID:14971907] |
| ChEMBL | Inhibitory concentration against human cystolic isozyme II of Carbonic anhydrase | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5703-5707 [PMID:15482952] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibitory activity against human carbonic anhydrase IV (hCAIV) | B | 5.07 | pKi | 8600 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931] |
| ChEMBL | Inhibition of cloned isozyme, human carbonic anhydrase IV | B | 5.55 | pKi | 2800 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775] |
| Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323] | ||||||||
| ChEMBL | Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C | B | 5.55 | pKi | 2800 | nM | Ki | J Med Chem (2004) 47: 1272-1279 [PMID:14971907] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method. | B | 5.55 | pKi | 2800 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV (CA4), isolated from bovine lung microsomes | B | 5.55 | pKi | 2800 | nM | Ki | J Med Chem (2000) 43: 292-300 [PMID:10649985] |
| ChEMBL | Inhibition of bovine carbonic anhydrase IV from bovine lung microsomes | B | 5.55 | pKi | 2800 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 1117-1120 [PMID:10843231] |
| ChEMBL | Inhibitory activity against bovine lung microsomes carbonic anhydrase isozyme IV (bCA IV). | B | 5.55 | pKi | 2800 | nM | Ki | J Med Chem (1999) 42: 2641-2650 [PMID:10411484] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV (CA4), isolated from bovine lung microsomes | B | 5.55 | pKi | 2800 | nM | Ki | J Med Chem (1999) 42: 3690-3700 [PMID:10479300] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV | B | 5.55 | pKi | 2800 | nM | Ki | J Med Chem (2002) 45: 1466-1476 [PMID:11906288] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV (bCAIV) | B | 5.55 | pKi | 2800 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX at 0.09 uM | B | 3.99 | pKi | 103000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| ChEMBL | Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX. | B | 6.99 | pKi | 103 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3283-3290 [PMID:15149691] |
| ChEMBL | Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method. | B | 6.99 | pKi | 103 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899] |
| ChEMBL | Inhibitory constant against catalytic domain of human carbonic anhydrase IX | B | 6.99 | pKi | 103 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21 | B | 6.99 | pKi | 103 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase IX | B | 6.99 | pKi | 103 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325] |
| ChEMBL | Inhibition of catalytic domain of human recombinant CA IX | B | 6.99 | pKi | 103 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay | B | 6.99 | pKi | 103 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay | B | 6.99 | pKi | 103 | nM | Ki | J Med Chem (2010) 53: 2913-2926 [PMID:20201556] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method | B | 6.99 | pKi | 103 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157] |
| ChEMBL | Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.99 | pKi | 103 | nM | Ki | Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibitory activity against human recombinant mitochondrial isozyme CA VA | B | 4.56 | pKi | 27600 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| ChEMBL | Inhibitory concentration against human cystolic isozyme V of Carbonic anhydrase | B | 4.56 | pIC50 | 27600 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5703-5707 [PMID:15482952] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibitory activity against human recombinant mitochondrial isozyme CA VB | B | 4.91 | pKi | 12300 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of full length human recombinant CA VI | B | 5.32 | pKi | 4800 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay | B | 5.32 | pKi | 4800 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay | B | 5.32 | pKi | 4800 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Ki value against human carbonic anhydrase VII | B | 7.12 | pKi | 75 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibitory constant against catalytic domain of human carbonic anhydrase XII | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| ChEMBL | Ki value against human carbonic anhydrase XII (hCA XII) | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894] |
| ChEMBL | Inhibition of human recombinant CA12 by stopped flow CO2 hydration assay | B | 9.52 | pKi | 0.3 | nM | Ki | J Med Chem (2010) 53: 2913-2926 [PMID:20201556] |
| ChEMBL | Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method | B | 7.39 | pKi | 41 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157] |
| ChEMBL | Ki value against murine carbonic anhydrase XIII | B | 7.39 | pKi | 41 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay | B | 5.49 | pKi | 3200 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| ChEMBL | Inhibition of human full length cloned transmembrane carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 5.49 | pKi | 3200 | nM | Ki | Bioorg Med Chem (2012) 20: 2392-2404 [PMID:22370338] |
| Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] | ||||||||
| ChEMBL | Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.37 | pKi | 424 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5767] [UniProtKB: P96878] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay | B | 5.13 | pKi | 7330 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511] |
| Son of sevenless homolog 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4524041] [UniProtKB: Q07890] | ||||||||
| ChEMBL | Binding affinity to biotinylated SOS2 (unknown origin) by surface plasmon resonance analysis | B | 2.7 | pKd | ~2000000 | nM | Kd | J Med Chem (2024) 67: 774-781 [PMID:38156904] |
| Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay | B | 5.06 | pKi | 8690 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay | B | 5.06 | pKi | 8690 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
