dutasteride [Ligand Id: 7457] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1200969 (Avodart, Avolve, Duastride, Dutasteride, GG-745, GI 198745, GI-198745, NSC-740477, NSC-759880)
  • glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Human [ChEMBL: CHEMBL5845] [GtoPdb: 423] [UniProtKB: P23415]
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  • steroid 5 alpha-reductase 2/Steroid 5-alpha-reductase 2 in Human [ChEMBL: CHEMBL1856] [GtoPdb: 2633] [UniProtKB: P31213]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5845] [GtoPdb: 423] [UniProtKB: P23415]
ChEMBL Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-electrode voltage clamp assay B 6.48 pEC50 330 nM EC50 J. Med. Chem. (2015) 58: 2958-2966 [PMID:25790278]
Steroid 5-alpha-reductase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1787] [UniProtKB: P18405]
ChEMBL Inhibition of human type 1 5alpha reductase B 8.4 pIC50 4 nM IC50 J Med Chem (2018) 61: 5822-5880 [PMID:29400967]
steroid 5 alpha-reductase 2/Steroid 5-alpha-reductase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1856] [GtoPdb: 2633] [UniProtKB: P31213]
ChEMBL Inhibition of human type 2 5alpha reductase B 10 pIC50 <0.1 nM IC50 J Med Chem (2018) 61: 5822-5880 [PMID:29400967]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]