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ChEMBL ligand: CHEMBL1200969 (Avodart, Avolve, Duastride, Dutasteride, GG-745, GI 198745, GI-198745, NSC-740477, NSC-759880) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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glycine receptor α1 subunit/Glycine receptor subunit alpha-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5845] [GtoPdb: 423] [UniProtKB: P23415] | ||||||||
ChEMBL | Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-electrode voltage clamp assay | B | 6.48 | pEC50 | 330 | nM | EC50 | J Med Chem (2015) 58: 2958-2966 [PMID:25790278] |
Steroid 5-alpha-reductase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1787] [UniProtKB: P18405] | ||||||||
ChEMBL | Inhibition of human type 1 5alpha reductase | B | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2018) 61: 5822-5880 [PMID:29400967] |
steroid 5 alpha-reductase 2/Steroid 5-alpha-reductase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1856] [GtoPdb: 2633] [UniProtKB: P31213] | ||||||||
ChEMBL | Inhibition of human type 2 5alpha reductase | B | 10 | pIC50 | <0.1 | nM | IC50 | J Med Chem (2018) 61: 5822-5880 [PMID:29400967] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]